DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir76b and GRIN2D

DIOPT Version :10

Sequence 1:NP_649176.1 Gene:Ir76b / 40198 FlyBaseID:FBgn0036937 Length:636 Species:Drosophila melanogaster
Sequence 2:NP_000827.2 Gene:GRIN2D / 2906 HGNCID:4588 Length:1336 Species:Homo sapiens


Alignment Length:596 Identity:128/596 - (21%)
Similarity:223/596 - (37%) Gaps:152/596 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    83 KHLRIATLEDFPLSYTEVLE--NGTRVGHGVSFQ------------------------IIDFLKK 121
            :||.:||||:.|....|..:  :||.:...|..:                        .||.||:
Human   430 QHLTVATLEERPFVIVEPADPISGTCIRDSVPCRSQLNRTHSPPPDAPRPEKRCCKGFCIDILKR 494

  Fly   122 ---KFNFTYEVVVPQDNIIGSPSD-FDRSLIEMVNSSTVDLAAAFIPSLSDQRS-FVYYSTTTLD 181
               ...|:|::.:..:...|...| ....:|..|.....|:|...: :::::|| .|.:|...::
Human   495 LAHTIGFSYDLYLVTNGKHGKKIDGVWNGMIGEVFYQRADMAIGSL-TINEERSEIVDFSVPFVE 558

  Fly   182 EGEWIMVMQRPRESASGSGLLAPFEFWVWILILVSLLAV-----------GPIIYALIILRNRLT 235
            .|..:|| .|...:.|.|..|.|:...||:::.|..|.|           .|:.|      ||..
Human   559 TGISVMV-ARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGY------NRSL 616

  Fly   236 GDGQQ---TPYSLGHCAWFVYGALMKQGSTL-SPIADSTRLLFATWWIFITILTSFYTANLTAFL 296
            ..|::   :.:::|...|.::..:......: :|...:::::...|..|..|..:.|||||.||:
Human   617 ATGKRPGGSTFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFM 681

  Fly   297 TLSKFTLPYNTVNDILTKN----------KHFVSMRGGGVEYAIRTTNESLSMLNRMIQNNYAVF 351
            ...::.   :||:.:..:.          ..|.::..|..|..||:        |....::|.| 
Human   682 IQEEYV---DTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIRS--------NYPDMHSYMV- 734

  Fly   352 SDETNDTYNLQNYVE------KNGYV--FVRDRPAINIMLYRDYLYRKTVSFSDEKVHCP--FAM 406
                  .|| |..||      |.|.:  |:.|...:|.|..:|. ..|.|:....||...  :.:
Human   735 ------RYN-QPRVEEALTQLKAGKLDAFIYDAAVLNYMARKDE-GCKLVTIGSGKVFATTGYGI 791

  Fly   407 AKEPFLKKKRTFAYPIGSNLSQLFDPELLHLVE----SGIVKHLSKRNLPSAEICPQDLGGTERQ 467
            |    |.|...:..||...|.|....:.:.::|    |||. |..|..:.|:::...::.|    
Human   792 A----LHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSGIC-HNDKIEVMSSKLDIDNMAG---- 847

  Fly   468 LRNGDLMMTYYIMLAGFATALAVFSTE-LMFRYVNSRQEANKW-ARHGIGRTPNGQSVAPSRWLR 530
                    .:|::|.....:|.||:.| |::           | .||.:|         |:..:.
Human   848 --------VFYMLLVAMGLSLLVFAWEHLVY-----------WRLRHCLG---------PTHRMD 884

  Fly   531 GWRRLNSGHGQLLGASTHGQNVTPPPPYQSIFN----------GGSHGDP-----LNRWRRPLAN 580
            .....:.|......|........||||.|.:.:          |.:...|     ::||||....
Human   885 FLLAFSRGMYSCCSAEAAPPPAKPPPPPQPLPSPAYPAPRPAPGPAPFVPRERASVDRWRRTKGA 949

  Fly   581 GNALGNGVLLG 591
            |...|.|:..|
Human   950 GPPGGAGLADG 960

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir76bNP_649176.1 Lig_chan-Glu_bd 83..192 CDD:463166 30/139 (22%)
Lig_chan 209..458 CDD:459656 63/287 (22%)
GRIN2DNP_000827.2 PBP1_iGluR_NMDA_NR2 49..413 CDD:380601
PBP2_iGluR_NMDA_Nr2 430..830 CDD:270436 95/432 (22%)
Pore-forming. /evidence=ECO:0000250|UniProtKB:Q00960 631..650 1/18 (6%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 900..934 6/33 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 981..1123
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1225..1336
PDZ-binding. /evidence=ECO:0000250 1334..1336
Blue background indicates that the domain is not in the aligned region.

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