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Protein Alignment Ir76b and GRIN2B

DIOPT Version :9

Sequence 1:	NP_649176.1	Gene:	Ir76b / 40198	FlyBaseID:	FBgn0036937	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_000825.2	Gene:	GRIN2B / 2904	HGNCID:	4586	Length:	1484	Species:	Homo sapiens

Alignment Length:	503	Identity:	120/503 - (23%)
Similarity:	196/503 - (38%)	Gaps:	126/503 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 RKKPKLREMLDWIGGKHLRIATLEDFPLSYTEVLE--NGTRVGHGVSFQ---------------- 114
            |..|:..|..|    .||.|.|||:.|....|.::  :||.:.:.|..|
Human   393 RMCPETEEQED----DHLSIVTLEEAPFVIVESVDPLSGTCMRNTVPCQKRIVTENKTDEEPGYI 453

  Fly   115 -------IIDFLK---KKFNFTYEVVVPQDNIIGSPSDFDRSLIEMVNSSTVDLAAAFIPSL--S 167
                   .||.||   |...|||::.:..:...|  ...:.:...|:....:..|...:.||  :
Human   454 KKCCKGFCIDILKKISKSVKFTYDLYLVTNGKHG--KKINGTWNGMIGEVVMKRAYMAVGSLTIN 516

  Fly   168 DQRS-FVYYSTTTLDEGEWIMVMQRPRESASGSGLLAPFEFWVWILILVSLLAVGPIIYALIILR 231
            ::|| .|.:|...::.|..:|| .|...:.|.|..|.||...||:::.|.||.|..:  |:.:..
Human   517 EERSEVVDFSVPFIETGISVMV-SRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAV--AVFVFE 578

  Fly   232 -------NRLTGDGQQ---TPYSLGHCAWFVYGALMKQGSTL-SPIADSTRLLFATWWIFITILT 285
                   ||...||::   ..:::|...|.::|.:......: :|...:::::.:.|..|..|..
Human   579 YFSPVGYNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFL 643

  Fly   286 SFYTANLTAF------------LTLSKFTLPYNTVNDILTKNKHFVSMRGGGVEYAIRTTNESLS 338
            :.|||||.||            |:..||..|    || .:....|.::..|..|
Human   644 ASYTANLAAFMIQEEYVDQVSGLSDKKFQRP----ND-FSPPFRFGTVPNGSTE----------- 692

  Fly   339 MLNRMIQNNYA---VFSDETNDTYNLQNYVE------KNGYV--FVRDRPAINIMLYRDYLYRKT 392
               |.|:||||   .:..:.|     |..|:      |.|.:  |:.|...:|.|..||. ..|.
Human   693 ---RNIRNNYAEMHAYMGKFN-----QRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDE-GCKL 748

  Fly   393 VSFSDEKVHCP----FAMAKEPFLKKKRTFAYPIGSNLSQLFD----PELLHLVESGIVKHLSKR 449
            |:....||...    .|:.|:...|::...|      :.|||.    .||..|..:||. |..|.
Human   749 VTIGSGKVFASTGYGIAIQKDSGWKRQVDLA------ILQLFGDGEMEELEALWLTGIC-HNEKN 806

  Fly   450 NLPSAEICPQDLGGTERQLRNGDLMMTYYIMLAGFATALAVFSTELMF 497
            .:.|:::...::.|            .:|::.|..|.:|..|..|.:|
Human   807 EVMSSQLDIDNMAG------------VFYMLGAAMALSLITFICEHLF 842

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.