Protein Alignment Ir76b and GRIN2A

DIOPT Version :10

• Sequence 1: NP_649176.1
• Gene: Ir76b / 40198
• FlyBaseID: FBgn0036937
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: XP_016878661.1
• Gene: GRIN2A / 2903
• HGNCID: 4585
• Length: 1516
• Species: Homo sapiens
• Alignment Length: 492
• Identity: 105/492 - (21%)
• Similarity: 183/492 - (37%)
• Gaps: 133/492 - (27%)

  Fly    84 HLRIATLEDFPLSYTEVLE--------------------NGTRVG-------HGVSFQIIDFLKK 121
            ||.|.|||:.|....|.::                    |.|..|       .|....|:..|.:
Human   457 HLSIVTLEEAPFVIVEDIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSR 521

  Fly   122 KFNFTYEVVVPQDNIIGSPSD--FDRSLIEMVNSSTVDLAAAFIPSLSDQRS-FVYYSTTTLDEG 183
            ...|||::.:..:...|...:  ::..:.|:|....|....:.  :::::|| .|.:|...::.|
Human   522 TVKFTYDLYLVTNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSL--TINEERSEVVDFSVPFVETG 584

  Fly   184 EWIMVMQRPRESASGSGLLAPFEFWVWILILVSLLAVGPIIYALIIL---------RNRLTGDGQ 239
            ..:|| .|...:.|.|..|.||...||:::.|.||.|..|  |:.:.         ||...|...
Human   585 ISVMV-SRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAI--AVFVFEYFSPVGYNRNLAKGKAP 646

  Fly   240 QTP-YSLGHCAWFVYGALMKQGSTL-SPIADSTRLLFATWWIFITILTSFYTANLTAFLTLSKFT 302
            ..| :::|...|.::|.:......: :|...:::::.:.|..|..|..:.|||||.||:...:|.
Human   647 HGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFV 711

  Fly   303 LPYNTVNDILTKNKH-------FVSMRGGGVEYAIRTTNESLSMLNRMIQNNYAVFSDETNDTYN 360
            .....::|...:..|       |.::..|..|              |.|:|||. :..:....:|
Human   712 DQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTE--------------RNIRNNYP-YMHQYMTKFN 761

  Fly   361 LQNYVE------KNGYV--FVRDRPAINIMLYRD-----------YLYRKTVSFSDEKVHCPFAM 406
             |..||      |.|.:  |:.|...:|....||           |::..|          .:.:
Human   762 -QKGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATT----------GYGI 815

  Fly   407 AKEPFLKKKRTFAYPIGSNLSQLFDPELLHLVESGIVK-----------HLSKRNLPSAEICPQD 460
            |    |:|        ||...:..|..||..|..|.::           |..|..:.|:::...:
Human   816 A----LQK--------GSPWKRQIDLALLQFVGDGEMEELETLWLTGICHNEKNEVMSSQLDIDN 868

  Fly   461 LGGTERQLRNGDLMMTYYIMLAGFATALAVFSTELMF 497
            :.|            .:|::.|..|.:|..|..|.:|
Human   869 MAG------------VFYMLAAAMALSLITFIWEHLF 893

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Lig_chan-Glu_bd	83..192	CDD:463166	28/137 (20%)
		Lig_chan	209..458	CDD:459656	63/296 (21%)
GRIN2A	XP_016878661.1	PBP1_iGluR_NMDA_NR2	84..439	CDD:380601
		PBP2_iGluR_NMDA_Nr2	455..854	CDD:270436	94/439 (21%)
		NMDAR2_C	891..1516	CDD:463148	1/3 (33%)