Protein Alignment Ir76b and GRIN1

DIOPT Version :10

• Sequence 1: NP_649176.1
• Gene: Ir76b / 40198
• FlyBaseID: FBgn0036937
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_001424259.1
• Gene: GRIN1 / 2902
• HGNCID: 4584
• Length: 959
• Species: Homo sapiens
• Alignment Length: 691
• Identity: 130/691 - (18%)
• Similarity: 233/691 - (33%)
• Gaps: 215/691 - (31%)

  Fly    47 VDASEAGFDADAPVETLETINRKK------------PKLREMLDWIGGK-----------HLRIA 88
            |:.:|.|....|....:...|||.            |..|::: |.||:           .|:|.
Human   359 VEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKII-WPGGETEKPRGYQMSTRLKIV 422

  Fly    89 TLEDFPLSYTE-VLENGT---------------------------------RVGHGVSFQIIDFL 119
            |:...|..|.: .|.:||                                 :..:|....::..|
Human   423 TIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKL 487

  Fly   120 KKKFNFTYEVVVPQDNIIGSPSDFDRS-------LIEMVNSSTVDLAAAFIPSLSDQRSFVYYST 177
            .:..||||||.:..|...|:....:.|       ::..:.|...|:..|.:...:::..::.:|.
Human   488 ARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSK 552

  Fly   178 TTLDEGEWIMVMQR-PRESASGSGLLAPFEFWVWILILVSLLAVGPIIYALIILRNRLTGDG--- 238
            ....:|..|:|.:. ||.:.  ...:.||:..:|:|:.:|:..|..::|.|    :|.:..|
Human   553 PFKYQGLTILVKKEIPRSTL--DSFMQPFQSTLWLLVGLSVHVVAVMLYLL----DRFSPFGRFK 611

  Fly   239 ------QQTPYSLGHCAWFVYGALMKQG-STLSPIADSTRLLFATWWIFITILTSFYTANLTAFL 296
                  ::...:|....||.:|.|:..| ...:|.:.|.|:|...|..|..|:.:.|||||.|||
Human   612 VNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFL 676

  Fly   297 TLSKFTLPYNTVNDILTKNKH----FVSMRGGGVEYAIRTTNESLSMLNRMIQNNY--------- 348
            .|.:.......:||...:|..    :.:::...|:...|...|..:|...|.::||
Human   677 VLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQA 741

  Fly   349 -------------AVFSDETNDTYNLQNYVEKNGYVFVRDRPAINIMLYRDYLYRKTVSFSDEKV 400
                         ||...|.:...:|..    .|.:|.|.  ...|.:.:|..:::.||.|..|.
Human   742 VRDNKLHAFIWDSAVLEFEASQKCDLVT----TGELFFRS--GFGIGMRKDSPWKQNVSLSILKS 800

  Fly   401 HCPFAMAKEPFLKKKRTFAYPIGSNLSQLFDPELLHLVESGIVKHL-----------SKRNLPSA 454
            |                                     |:|.::.|           |:.|.| |
Human   801 H-------------------------------------ENGFMEDLDKTWVRYQECDSRSNAP-A 827

  Fly   455 EICPQDLGGTERQLRNGDLMMTYYIMLAGFATALAVFSTELMFRYVNSRQEANKWARHGIGRTPN 519
            .:..:::.|            .:.::..|....:.:...|:.::            ||...|...
Human   828 TLTFENMAG------------VFMLVAGGIVAGIFLIFIEIAYK------------RHKDARRKQ 868

  Fly   520 GQ--SVAPSRWLRGWRRLNSGHGQLLGASTHGQNVTPPPPYQSIFNGGSHGDPLNRWRRPLANGN 582
            .|  ..|.:.|.:..:...||..:            |.|..::.|...:.....:..||..:...
Human   869 MQLAFAAVNVWRKNLQDRKSGRAE------------PDPKKKATFRAITSTLASSFKRRRSSKDT 921

  Fly   583 ALGNGVLLGGDSEGGVRRLINGRDYMVFR----NPNGQSQL 619
            :.|          ||...|.|.:|.::.|    ...||.||
Human   922 STG----------GGRGALQNQKDTVLPRRAIEREEGQLQL 952

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Lig_chan-Glu_bd	83..192	CDD:463166	26/161 (16%)
		Lig_chan	209..458	CDD:459656	61/295 (21%)
GRIN1	NP_001424259.1	None