Protein Alignment Ir76b and GRIK4

DIOPT Version :10

• Sequence 1: NP_649176.1
• Gene: Ir76b / 40198
• FlyBaseID: FBgn0036937
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_055434.2
• Gene: GRIK4 / 2900
• HGNCID: 4582
• Length: 956
• Species: Homo sapiens
• Alignment Length: 556
• Identity: 137/556 - (24%)
• Similarity: 218/556 - (39%)
• Gaps: 105/556 - (18%)

  Fly    89 TLEDFPLSYTEVLEN-------------GTRVGHGVSFQIIDFLKKKFNFTYEVVVPQDNIIGSP 140
            ||.:..|..|.:|||             |.....|....::..|.:...|.|::.:..|.:.|.|
Human   412 TLFNTTLVVTTILENPYLMLKGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVP 476

  Fly   141 SDFDRSLIEMVN---SSTVDLAAAFIPSLSDQRSFVYYSTTTLDEGEWIMVMQRPRESASGSGLL 202
             :.:.:...||.   :...|||.|.:...:::...:.:|...:..|..|:..............|
Human   477 -EANGTWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFL 540

  Fly   203 APFEFWVWILILVSLLAVGPIIYALIILRNRLTGDGQQTP--------------YSLGHCAWFVY 253
            .||...||:.:|::.|||..:::    |..|||.....:|              ||||:..||..
Human   541 DPFSPGVWLFMLLAYLAVSCVLF----LVARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFPV 601

  Fly   254 GALMKQGSTLSPIADSTRLLFATWWIFITILTSFYTANLTAFLTLSKFTLPYNTVNDILTKNKHF 318
            |..|:||||::|.|.|||.:...||.|..|:.|.|||||.||||:.:..:|..:|:|:..:.
Human   602 GGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLADQT--- 663

  Fly   319 VSMRGGGVEYAIRTTNESLSMLNRMIQNNYAVFSDETNDTY-NLQNYV-EKNGYVFVRD-RPAIN 380
                  .:||.  |.:...||         ..|.:....|| .:.||: .|...|||:. ...|.
Human   664 ------AIEYG--TIHGGSSM---------TFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIA 711

  Fly   381 IMLYRDY--LYRKTVSFSDEKVHCPFAMAKEPFLKKKRTFAYPIGSNLSQLFDPELLHLVESGIV 443
            .:|..:|  |...|::....:.:|...........|......|:||.....||..:|.|.|:..:
Human   712 RVLNSNYAFLLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRL 776

  Fly   444 KHLSKRNLPSAEICPQDLGGTERQLRNGDLMMTYYIMLAGFATALAVFSTELMFRYVNSRQEANK 508
            :.| ||.......||::.....:.|...::...:.:::.|.  .:|:|...|.|.:.....||.:
Human   777 EIL-KRKWWEGGKCPKEEDHRAKGLGMENIGGIFVVLICGL--IVAIFMAMLEFLWTLRHSEATE 838

  Fly   509 WA--RHGIGRTPN----GQSVAPSRWLRGWRRLNSGHGQLLGASTHGQNVTPPPPYQSIFNGGSH 567
            .:  :..:....:    ..|:.|.|     ||               ..|.||.|
Human   839 VSVCQEMVTELRSIILCQDSIHPRR-----RR---------------AAVPPPRP---------- 873

  Fly   568 GDPLNRWRRPLANGNA-LGNGVLLG-GDSEGGVRRL 601
              |:...|||  .|.| |.||.|.| |:.:...:||
Human   874 --PIPEERRP--RGTATLSNGKLCGAGEPDQLAQRL 905

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Lig_chan-Glu_bd	83..192	CDD:463166	24/118 (20%)
		Lig_chan	209..458	CDD:459656	77/267 (29%)
GRIK4	NP_055434.2	PBP1_iGluR_Kainate_KA1_2	24..402	CDD:380616
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	102/395 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	863..889		14/59 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	931..956