Protein Alignment Ir76b and GRIK3

DIOPT Version :10

• Sequence 1: NP_649176.1
• Gene: Ir76b / 40198
• FlyBaseID: FBgn0036937
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_000822.2
• Gene: GRIK3 / 2899
• HGNCID: 4581
• Length: 919
• Species: Homo sapiens
• Alignment Length: 541
• Identity: 109/541 - (20%)
• Similarity: 204/541 - (37%)
• Gaps: 151/541 - (27%)

  Fly    34 NGTLSPVTELPMD-VDASEAGFD---ADAPVETLETINRKKPKLREMLDWIGGKHLRIATLEDFP 94
            |.|....|:..:| :...|.|.:   ..:|.:.|......|.:...:.|.:..:.|.:.|:.:.|
Human   381 NKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVAKGRGPNVTDSLTNRSLIVTTVLEEP 445

  Fly    95 LSYTEVLENGTRVGHGVS-FQ--IIDFLKKK---FNFTYEVVVPQDNIIGSPSDFDR--SLIEMV 151
            .   .:.....|..:|.. |:  .||.||:.   ..|:||:.:.:|...|:..|..:  .:::.:
Human   446 F---VMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKEL 507

  Fly   152 NSSTVDLAAAFIPSLSDQRSFVYYSTTTLDEGEWIMVMQRPRESASGSGLLAPFEFWVWILILVS 216
            .....|||.|.:.....:...:.:|...:..|..|:..:....:.|....|.|....:|:.:|::
Human   508 IDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLA 572

  Fly   217 LLAVGPIIYALI------------------ILRNRLTGDGQQTPYSLGHCAWFVYGALMKQGSTL 263
            .|.|..:::.:.                  ::.|..|         |.:..||..|:||:|||.|
Human   573 YLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFT---------LLNSFWFGMGSLMQQGSEL 628

  Fly   264 SPIADSTRLLFATWWIFITILTSFYTANLTAFLTLSKFTLPYNTVNDILTKNKHFVSMRGGGVEY 328
            .|.|.|||::...||.|..|:.|.|||||.||||:.:...|.::.:|:..:.|         :||
Human   629 MPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTK---------IEY 684

  Fly   329 -AIR-------------TTNESL-----SMLNRMIQNN-----------YAVFSDETNDTYNLQ- 362
             |::             :|.|.:     |..:.:::||           ||:..:.|...|..|
Human   685 GAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRALTADYALLMESTTIEYVTQR 749

  Fly   363 --------NYVEKNGYVF-------VRDRPAINIMLYRDYLYRKTVSFSDEKVHCPFAMAKEPFL 412
                    ..::..||..       .||:..|.|:..::          ::|:|    :.||.:.
Human   750 NCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQE----------EDKLH----IMKEKWW 800

  Fly   413 KKKRTFAYPIGSNLSQLFDPELLHLVESGIVKHLSKRNLPSAEICPQDLGGTERQLRNGDLMMTY 477
            :         ||..     ||              :.|..::.:..|.:||            .:
Human   801 R---------GSGC-----PE--------------EENKEASALGIQKIGG------------IF 825

  Fly   478 YIMLAGFATALAVFSTELMFR 498
            .::.||...::.|...|.:::
Human   826 IVLAAGLVLSVLVAVGEFVYK 846

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Lig_chan-Glu_bd	83..192	CDD:463166	23/116 (20%)
		Lig_chan	209..458	CDD:459656	66/312 (21%)
GRIK3	NP_000822.2	PBP1_iGluR_Kainate	37..417	CDD:380605	8/35 (23%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	87/402 (22%)