DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir76b and GRIK2

DIOPT Version :9

Sequence 1:NP_649176.1 Gene:Ir76b / 40198 FlyBaseID:FBgn0036937 Length:636 Species:Drosophila melanogaster
Sequence 2:NP_068775.1 Gene:GRIK2 / 2898 HGNCID:4580 Length:908 Species:Homo sapiens


Alignment Length:511 Identity:114/511 - (22%)
Similarity:196/511 - (38%) Gaps:91/511 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    41 TELPMDV-DASEAGFDADA---PVETLETINRKKPKLREMLDWIGGKHLRIATL----------E 91
            |:..:|| ...|.|.:...   |...|.....:|.|...:.|.:..:.|.:.|:          .
Human   385 TDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKS 449

  Fly    92 DFPLSYTEVLENGTRVGHGVSFQIIDFLKKKFNFTYEVVVPQDNIIGSPSDFD-------RSLIE 149
            |.||...:..|       |....::..|.....||||:.:.:|...|:..|.:       |.||:
Human   450 DKPLYGNDRFE-------GYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELID 507

  Fly   150 MVNSSTVDLAAAFIPSLSDQRSFVYYSTTTLDEGEWIMVM------QRPRESASG-SGLLAPFEF 207
                ...|||.|.:       :..|.....:|..:..|.:      ::|..:..| ...|.|...
Human   508 ----HKADLAVAPL-------AITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSP 561

  Fly   208 WVWILILVSLLAVGPIIYALIILRNRLT-------------GDGQQTPYSLGHCAWFVYGALMKQ 259
            .:|:.||::.|.|..:::.:.    |.:             .|..:..::|.:..||..||||:|
Human   562 DIWMYILLAYLGVSCVLFVIA----RFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQ 622

  Fly   260 GSTLSPIADSTRLLFATWWIFITILTSFYTANLTAFLTLSKFTLPYNTVNDILTKNKHFVSMRGG 324
            ||.|.|.|.|||::...||.|..|:.|.|||||.||||:.:...|.::.:|:..:.|    :..|
Human   623 GSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTK----IEYG 683

  Fly   325 GVEYAIRTT---NESLSMLNRMIQNNYAVFSDETNDTYNLQNYVEKNGYVFVRDRPAINIMLYRD 386
            .||.....|   ...:|..::|    :|..|...      |:.:.|:      :...|..:|..|
Human   684 AVEDGATMTFFKKSKISTYDKM----WAFMSSRR------QSVLVKS------NEEGIQRVLTSD 732

  Fly   387 YLY---RKTVSFSDEKVHCPFAMAKEPFLKKKRTFAYPIGSNLSQLFDPELLHLVESGIVKHLSK 448
            |.:   ..|:.|..:: :|...........|......|:||.........:|.|.|.|.: |:.|
Human   733 YAFLMESTTIEFVTQR-NCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKL-HMMK 795

  Fly   449 RNLPSAEICPQDLGGTERQLRNGDLMMTYYIMLAGFATALAVFSTELMFRYVNSRQ 504
            ........||::.......|...::...:.::.||...::.|...|.:::...:.|
Human   796 EKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQ 851

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Ir76bNP_649176.1 Periplasmic_Binding_Protein_Type_2 83..437 CDD:304360 91/396 (23%)
GRIK2NP_068775.1 PBP1_iGluR_Kainate 37..414 CDD:380605 7/28 (25%)
Periplasmic_Binding_Protein_Type_2 430..800 CDD:419667 96/413 (23%)
Glutamate binding. /evidence=ECO:0000250|UniProtKB:P42260 516..518 0/8 (0%)