Protein Alignment Ir76b and GRIK2

DIOPT Version :10

• Sequence 1: NP_649176.1
• Gene: Ir76b / 40198
• FlyBaseID: FBgn0036937
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_068775.1
• Gene: GRIK2 / 2898
• HGNCID: 4580
• Length: 908
• Species: Homo sapiens
• Alignment Length: 511
• Identity: 114/511 - (22%)
• Similarity: 196/511 - (38%)
• Gaps: 91/511 - (17%)

  Fly    41 TELPMDV-DASEAGFDADA---PVETLETINRKKPKLREMLDWIGGKHLRIATL----------E 91
            |:..:|| ...|.|.:...   |...|.....:|.|...:.|.:..:.|.:.|:          .
Human   385 TDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKS 449

  Fly    92 DFPLSYTEVLENGTRVGHGVSFQIIDFLKKKFNFTYEVVVPQDNIIGSPSDFD-------RSLIE 149
            |.||...:..|       |....::..|.....||||:.:.:|...|:..|.:       |.||:
Human   450 DKPLYGNDRFE-------GYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELID 507

  Fly   150 MVNSSTVDLAAAFIPSLSDQRSFVYYSTTTLDEGEWIMVM------QRPRESASG-SGLLAPFEF 207
                ...|||.|.:       :..|.....:|..:..|.:      ::|..:..| ...|.|...
Human   508 ----HKADLAVAPL-------AITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSP 561

  Fly   208 WVWILILVSLLAVGPIIYALIILRNRLT-------------GDGQQTPYSLGHCAWFVYGALMKQ 259
            .:|:.||::.|.|..:::.:.    |.:             .|..:..::|.:..||..||||:|
Human   562 DIWMYILLAYLGVSCVLFVIA----RFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQ 622

  Fly   260 GSTLSPIADSTRLLFATWWIFITILTSFYTANLTAFLTLSKFTLPYNTVNDILTKNKHFVSMRGG 324
            ||.|.|.|.|||::...||.|..|:.|.|||||.||||:.:...|.::.:|:..:.|    :..|
Human   623 GSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTK----IEYG 683

  Fly   325 GVEYAIRTT---NESLSMLNRMIQNNYAVFSDETNDTYNLQNYVEKNGYVFVRDRPAINIMLYRD 386
            .||.....|   ...:|..::|    :|..|...      |:.:.|:      :...|..:|..|
Human   684 AVEDGATMTFFKKSKISTYDKM----WAFMSSRR------QSVLVKS------NEEGIQRVLTSD 732

  Fly   387 YLY---RKTVSFSDEKVHCPFAMAKEPFLKKKRTFAYPIGSNLSQLFDPELLHLVESGIVKHLSK 448
            |.:   ..|:.|..:: :|...........|......|:||.........:|.|.|.|.: |:.|
Human   733 YAFLMESTTIEFVTQR-NCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKL-HMMK 795

  Fly   449 RNLPSAEICPQDLGGTERQLRNGDLMMTYYIMLAGFATALAVFSTELMFRYVNSRQ 504
            ........||::.......|...::...:.::.||...::.|...|.:::...:.|
Human   796 EKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQ 851

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Lig_chan-Glu_bd	83..192	CDD:463166	25/131 (19%)
		Lig_chan	209..458	CDD:459656	67/267 (25%)
GRIK2	NP_068775.1	PBP1_iGluR_Kainate	37..414	CDD:380605	7/28 (25%)
		Periplasmic_Binding_Protein_Type_2	430..800	CDD:473866	96/413 (23%)