Protein Alignment Ir76b and GRIK1

DIOPT Version :10

• Sequence 1: NP_649176.1
• Gene: Ir76b / 40198
• FlyBaseID: FBgn0036937
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_001317923.1
• Gene: GRIK1 / 2897
• HGNCID: 4579
• Length: 949
• Species: Homo sapiens
• Alignment Length: 556
• Identity: 112/556 - (20%)
• Similarity: 204/556 - (36%)
• Gaps: 142/556 - (25%)

  Fly    27 NLIQMGENGTLSPVTEL---------PMDVDASEAGFDADAPVETLETINRKKPKLREMLDWIGG 82
            ::|.:.|.||.....|:         .:.:..|.:|         |...:..|.|...:.|.:..
Human   391 DIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSNSG---------LNMTDSNKDKSSNITDSLAN 446

  Fly    83 KHLRIATL----------EDFPLSYTEVLENGTRVGHGVSFQIIDFLKKKFN---FTYEVVVPQD 134
            :.|.:.|:          .|.||...:..|.          ..:|.||:..|   |.|:|.:..|
Human   447 RTLIVTTILEEPYVMYRKSDKPLYGNDRFEG----------YCLDLLKELSNILGFIYDVKLVPD 501

  Fly   135 NIIGSPSDFD--RSLIEMVNSSTVDLAAAFIPSLSDQRSFVYYSTTTLDEGEWIMVM------QR 191
            ...|:.:|..  ..:::.:.....|||.|.:       :..|.....:|..:..|.:      ::
Human   502 GKYGAQNDKGEWNGMVKELIDHRADLAVAPL-------TITYVREKVIDFSKPFMTLGISILYRK 559

  Fly   192 PRESASG-SGLLAPFEFWVWILILVSLLAVGPIIYALIILRNRLT-------------GDGQQTP 242
            |..:..| ...|.|....:|:.:|::.|.|..:::.:.    |.|             .|..:..
Human   560 PNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIA----RFTPYEWYNPHPCNPDSDVVENN 620

  Fly   243 YSLGHCAWFVYGALMKQGSTLSPIADSTRLLFATWWIFITILTSFYTANLTAFLTLSKFTLPYNT 307
            ::|.:..||..||||:|||.|.|.|.|||::...||.|..|:.|.|||||.||||:.:...|.::
Human   621 FTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDS 685

  Fly   308 VNDILTKNK-HFVSMRGGGV--------------EYAIRTTNESLSM-------LNRMIQNNYAV 350
            .:|:..:.| .:.::|.|..              .:|..::.:..::       :.|::..:||:
Human   686 ADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTDYAL 750

  Fly   351 FSDETNDTYNLQ---NYVEKNGYVFVRDRPAINIMLYRDYLYRKTVSFSDEKVHCPFAMAKEPFL 412
            ..:.|:..|..|   |..:..|.:                         |.|.:
Human   751 LMESTSIEYVTQRNCNLTQIGGLI-------------------------DSKGY----------- 779

  Fly   413 KKKRTFAYPIGSNLSQLFDPELLHLVESGIVKHLSKRNLPSAEICPQDLGGTERQLRNGDLMMTY 477
                ....||||.........:|.|.|.|.: |:.|........||::.......|...::...:
Human   780 ----GVGTPIGSPYRDKITIAILQLQEEGKL-HMMKEKWWRGNGCPEEDNKEASALGVENIGGIF 839

  Fly   478 YIMLAGFATALAVFSTELMF--RYVNSRQEANKWAR 511
            .::.||...::.|...|.::  |..|..::..|.:|
Human   840 IVLAAGLVLSVFVAIGEFIYKSRKNNDIEQKGKSSR 875

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Lig_chan-Glu_bd	83..192	CDD:463166	23/129 (18%)
		Lig_chan	209..458	CDD:459656	63/286 (22%)
GRIK1	NP_001317923.1	PBP1_iGluR_Kainate	38..431	CDD:380605	8/48 (17%)
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:473866	90/430 (21%)