Protein Alignment Ir76b and GRID1

DIOPT Version :10

• Sequence 1: NP_649176.1
• Gene: Ir76b / 40198
• FlyBaseID: FBgn0036937
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_060021.1
• Gene: GRID1 / 2894
• HGNCID: 4575
• Length: 1009
• Species: Homo sapiens
• Alignment Length: 620
• Identity: 152/620 - (24%)
• Similarity: 245/620 - (39%)
• Gaps: 119/620 - (19%)

  Fly    74 REMLDWIGGKHLRIATL--EDFPLSYTEVLENGTRVGHGVSFQIIDFLKKKFNFTYEVVVPQDNI 136
            |.|...:.|..|::.|:  |.|.:....:|....|. .|.|..::|.|.|...|.||:....|..
Human   428 RPMGSRLQGLTLKVVTVLEEPFVMVAENILGQPKRY-KGFSIDVLDALAKALGFKYEIYQAPDGR 491

  Fly   137 IGSP---SDFDRSLIEMVNSSTVDLAAAFIPSLSDQRSFVYYSTTTLDEGEWIMVMQRPRESASG 198
            .|..   :.::..:.|:: |...|||.:.|....::.|.|.:|...:|....|:: ::|.|..|.
Human   492 YGHQLHNTSWNGMIGELI-SKRADLAISAITITPERESVVDFSKRYMDYSVGILI-KKPEEKISI 554

  Fly   199 SGLLAPFEFWVWILILVSLLAVGPIIYALIILRNRLTGDGQQT--------PYSLGHCAWFVYGA 255
            ..|.|||:|.||..|..::..||.:|:.|    ||:.....|:        ..:|....|.||||
Human   555 FSLFAPFDFAVWACIAAAIPVVGVLIFVL----NRIQAVRAQSAAQPRPSASATLHSAIWIVYGA 615

  Fly   256 LMKQGSTLSPIADSTRLLFATWWIFITILTSFYTANLTAFLTLSKFTLPYNTVNDILTKNKHFVS 320
            .::||...|..:.:.|::..:||:|..|:.|.|||||.||||:|:...|..|..| |:|.   |.
Human   616 FVQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQD-LSKQ---VE 676

  Fly   321 MRGGGVE-------YAIRTTN-----ESLSMLNRMIQNNYAVFSDETNDTYNLQNYVEKNGYVFV 373
            |..|.|.       :..:.||     .:.:.|.|.|..|....:..::.:..::. .:|..|.|:
Human   677 MSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADNCVSSPSEGIRK-AKKGNYAFL 740

  Fly   374 RDRPAINIMLYRDYLYRKTVSFSDEKVHCPFAMAKEPFLKKKRTFAYPIGSNLSQLFDPELLHLV 438
            .|   :.::.|        .:.:|:  .|...:.......|....|...||....||...:|.|.
Human   741 WD---VAVVEY--------AALTDD--DCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQ 792

  Fly   439 ESG---IVK-----HLSKRNLPSAEICPQDLGGTERQLRNGDLMMTYYIMLAGFATALAVFSTEL 495
            ::|   ::|     |:.:.:|.|......|    .:.|:.......:.|:..|...|..|.:.||
Human   793 DTGDLDVLKQKWWPHMGRCDLTSHASAQAD----GKSLKLHSFAGVFCILAIGLLLACLVAALEL 853

  Fly   496 MFRYVNSRQEANKWARHGIGRTPNGQSVAPSRWLRGWRRLNS------GHGQL-----------L 543
            .:......||..|     ..:..|.:.|        .||:||      .|.|:           :
Human   854 WWNSNRCHQETPK-----EDKEVNLEQV--------HRRMNSLMDEDIAHKQISPASIELSALEM 905

  Fly   544 GASTHGQNVTPPPPYQ------SIF--NGGSHGDPLNRWRRPLANGNALGNGVLLGGDSEGGVRR 600
            |.....|.:.|...||      |.|  ...|||.     .|.|::|.:....:.|...:.....:
Human   906 GGLAPTQTLEPTREYQNTQLSVSTFLPEQSSHGT-----SRTLSSGPSSNLPLPLSSSATMPSMQ 965

  Fly   601 LINGRDYMVFRNPNG----QSQLVPVRSPSAALFQ 631
            ..:       |:|||    ||   ||::|....||
Human   966 CKH-------RSPNGGLFRQS---PVKTPIPMSFQ 990

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Lig_chan-Glu_bd	83..192	CDD:463166	27/113 (24%)
		Lig_chan	209..458	CDD:459656	70/276 (25%)
GRID1	NP_060021.1	Interaction with CBLN1. /evidence=ECO:0000250|UniProtKB:Q61627	21..436		2/7 (29%)
		PBP1_iGluR_delta_1	25..425	CDD:380615
		PBP2_iGluR_delta_1	436..806	CDD:270448	103/394 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	930..954		7/28 (25%)