DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir76b and GRIA3

DIOPT Version :10

Sequence 1:NP_649176.1 Gene:Ir76b / 40198 FlyBaseID:FBgn0036937 Length:636 Species:Drosophila melanogaster
Sequence 2:NP_000819.4 Gene:GRIA3 / 2892 HGNCID:4573 Length:894 Species:Homo sapiens


Alignment Length:481 Identity:102/481 - (21%)
Similarity:190/481 - (39%) Gaps:71/481 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    88 ATLEDFPLSYTEVLEN-------------GTRVGHGVSFQIIDFLKKKFNFTYEVVVPQDNIIGS 139
            |:.|:..:..|.:||:             |.....|....:...:.|.....|::.:..|...|:
Human   418 ASSENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGA 482

  Fly   140 PSDFDRSLIEMVNS---STVDLAAAFIPSLSDQRSFVYYSTTTLDEGEWIMVMQRPRESASG-SG 200
            .....:....||..   ...|:|.|.:.....:...:.:|...:..|..||: ::|::|..| ..
Human   483 RDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMI-KKPQKSKPGVFS 546

  Fly   201 LLAPFEFWVWILILVSLLAVGPIIYALIILR-----------NRLTGDGQQTP-----YSLGHCA 249
            .|.|..:.:|:.|:.:.:.|..:::  ::.|           |....|.|..|     :.:.:..
Human   547 FLDPLAYEIWMCIVFAYIGVSVVLF--LVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSL 609

  Fly   250 WFVYGALMKQGSTLSPIADSTRLLFATWWIFITILTSFYTANLTAFLTLSKFTLPYNTVNDILTK 314
            ||..||.|:||..:||.:.|.|::...||.|..|:.|.|||||.||||:.:...|..:..|:..:
Human   610 WFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQ 674

  Fly   315 NK-HFVSMRGGGVEYAIRTTNESL--SMLNRMIQNNYAVFSDETNDTYNLQNYVEKNGYVFVRDR 376
            .: .:.::..|..:...|.:..::  .|.:.|.....:||:..|.|..   ..|.|:...|.   
Human   675 TEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGV---ARVRKSKGKFA--- 733

  Fly   377 PAINIMLYRDYLYRKTVS-FSDEKVHCPFAMAKEPFLKKKRTFAYPIGSNLSQLFDPELLHLVES 440
                      :|...|:: :.:::..|...........|....|.|.||.|....:..:|.|.|.
Human   734 ----------FLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRNAVNLAVLKLNEQ 788

  Fly   441 GIVKHLSKRNLPSAEICPQDLGGTERQLRNGDLMMT-----YYIMLAGFATALAVFSTELMFRYV 500
            |::..|..:.......|..  ||.:.:.:...|.::     :||::.|...|:.|...|..::  
Human   789 GLLDKLKNKWWYDKGECGS--GGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCYK-- 849

  Fly   501 NSRQEANKWARHGIGRTPNGQSVAPS 526
             ||.|:.:     :..|.|.|:..|:
Human   850 -SRAESKR-----MKLTKNTQNFKPA 869

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir76bNP_649176.1 Lig_chan-Glu_bd 83..192 CDD:463166 20/119 (17%)
Lig_chan 209..458 CDD:459656 60/268 (22%)
GRIA3NP_000819.4 PBP1_iGluR_AMPA_GluR3 35..409 CDD:380610
PBP2_iGluR_AMPA 422..805 CDD:270433 83/401 (21%)
Blue background indicates that the domain is not in the aligned region.

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