Protein Alignment Ir76b and GRIA2

DIOPT Version :10

• Sequence 1: NP_649176.1
• Gene: Ir76b / 40198
• FlyBaseID: FBgn0036937
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_000817.5
• Gene: GRIA2 / 2891
• HGNCID: 4572
• Length: 883
• Species: Homo sapiens
• Alignment Length: 589
• Identity: 132/589 - (22%)
• Similarity: 220/589 - (37%)
• Gaps: 150/589 - (25%)

  Fly    27 NLIQMGENG------------TLSPVTELPMDVDASEAGFDADAPVET--LETINRKKPKLREML 77
            |::::..||            .:..:||||...|.|  |.:....|.|  ||:......|..|||
Human   374 NIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTS--GLENKTVVVTTILESPYVMMKKNHEML 436

  Fly    78 DWIGGKHLRIATLEDFPLSYTEVLENGTRVGHGVSFQIIDFLKKKFNFTYEVVVPQDNIIGSPSD 142
            :                         |.....|....:...:.|...|.|::.:..|...|: .|
Human   437 E-------------------------GNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGA-RD 475

  Fly   143 FDRSLIE-MVNS---STVDLAAAFIPSLSDQRSFVYYSTTTLDEGEWIMVMQRPRESASG-SGLL 202
            .|..:.. ||..   ...|:|.|.:.....:...:.:|...:..|..||: ::|::|..| ...|
Human   476 ADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMI-KKPQKSKPGVFSFL 539

  Fly   203 APFEFWVWILILVSLLAVGPIIYALIILRNRLT---------GDGQQT-------PYSLGHCAWF 251
            .|..:.:|:.|:.:.:.|..:::    |.:|.:         .||::|       .:.:.:..||
Human   540 DPLAYEIWMCIVFAYIGVSVVLF----LVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWF 600

  Fly   252 VYGALMKQGSTLSPIADSTRLLFATWWIFITILTSFYTANLTAFLTLSKFTLP------------ 304
            ..||.|:||..:||.:.|.|::...||.|..|:.|.|||||.||||:.:...|
Human   601 SLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTE 665

  Fly   305 --YNTVNDILTK-----------NKHFVSMRGGGVEYAIRTTNESLSMLNRMIQNNYAVFSDETN 356
              |.|::...||           :|.:..||.......:|||.|.::.: |..:..||...:.|
Human   666 IAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARV-RKSKGKYAYLLEST- 728

  Fly   357 DTYNLQNYVEKNGYVFVRDRPAINIMLYRDYLYRKTVSFSDEKVHCPFAMAKEPFLKKKRTFAYP 421
                :..|:|:        |...:.|        |.....|.|.:               ..|.|
Human   729 ----MNEYIEQ--------RKPCDTM--------KVGGNLDSKGY---------------GIATP 758

  Fly   422 IGSNLSQLFDPELLHLVESGIVKHL-SKRNLPSAEICPQDLGGTER--QLRNGDLMMTYYIMLAG 483
            .||:|....:..:|.|.|.|::..| :|......|...:|.|..|:  .|...::...:||::.|
Human   759 KGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVGG 823

  Fly   484 FATALAVFSTELMFRYVNSRQEANKWARHGIGRTPNGQSVAPSRWLRGWRRLNSGHGQLLGASTH 548
            ...|:.|...|..::   ||.||.:     :....|.|::.||         :|.:.|.......
Human   824 LGLAMLVALIEFCYK---SRAEAKR-----MKVAKNAQNINPS---------SSQNSQNFATYKE 871

  Fly   549 GQNV 552
            |.||
Human   872 GYNV 875

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Lig_chan-Glu_bd	83..192	CDD:463166	18/112 (16%)
		Lig_chan	209..458	CDD:459656	68/290 (23%)
GRIA2	NP_000817.5	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	3/23 (13%)
		PBP2_iGluR_AMPA	413..794	CDD:270433	98/448 (22%)
		Required for interaction with IQSEC1. /evidence=ECO:0000250|UniProtKB:P19491	867..877		3/9 (33%)