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Protein Alignment Ir76b and GRIA2

DIOPT Version :9

Sequence 1:	NP_649176.1	Gene:	Ir76b / 40198	FlyBaseID:	FBgn0036937	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_000817.5	Gene:	GRIA2 / 2891	HGNCID:	4572	Length:	883	Species:	Homo sapiens

Alignment Length:	589	Identity:	132/589 - (22%)
Similarity:	220/589 - (37%)	Gaps:	150/589 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 NLIQMGENG------------TLSPVTELPMDVDASEAGFDADAPVET--LETINRKKPKLREML 77
            |::::..||            .:..:||||...|.|  |.:....|.|  ||:......|..|||
Human   374 NIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTS--GLENKTVVVTTILESPYVMMKKNHEML 436

  Fly    78 DWIGGKHLRIATLEDFPLSYTEVLENGTRVGHGVSFQIIDFLKKKFNFTYEVVVPQDNIIGSPSD 142
            :                         |.....|....:...:.|...|.|::.:..|...|: .|
Human   437 E-------------------------GNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGA-RD 475

  Fly   143 FDRSLIE-MVNS---STVDLAAAFIPSLSDQRSFVYYSTTTLDEGEWIMVMQRPRESASG-SGLL 202
            .|..:.. ||..   ...|:|.|.:.....:...:.:|...:..|..||: ::|::|..| ...|
Human   476 ADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMI-KKPQKSKPGVFSFL 539

  Fly   203 APFEFWVWILILVSLLAVGPIIYALIILRNRLT---------GDGQQT-------PYSLGHCAWF 251
            .|..:.:|:.|:.:.:.|..:::    |.:|.:         .||::|       .:.:.:..||
Human   540 DPLAYEIWMCIVFAYIGVSVVLF----LVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWF 600

  Fly   252 VYGALMKQGSTLSPIADSTRLLFATWWIFITILTSFYTANLTAFLTLSKFTLP------------ 304
            ..||.|:||..:||.:.|.|::...||.|..|:.|.|||||.||||:.:...|
Human   601 SLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTE 665

  Fly   305 --YNTVNDILTK-----------NKHFVSMRGGGVEYAIRTTNESLSMLNRMIQNNYAVFSDETN 356
              |.|::...||           :|.:..||.......:|||.|.::.: |..:..||...:.|
Human   666 IAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARV-RKSKGKYAYLLEST- 728

  Fly   357 DTYNLQNYVEKNGYVFVRDRPAINIMLYRDYLYRKTVSFSDEKVHCPFAMAKEPFLKKKRTFAYP 421
                :..|:|:        |...:.|        |.....|.|.:               ..|.|
Human   729 ----MNEYIEQ--------RKPCDTM--------KVGGNLDSKGY---------------GIATP 758

  Fly   422 IGSNLSQLFDPELLHLVESGIVKHL-SKRNLPSAEICPQDLGGTER--QLRNGDLMMTYYIMLAG 483
            .||:|....:..:|.|.|.|::..| :|......|...:|.|..|:  .|...::...:||::.|
Human   759 KGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVGG 823

  Fly   484 FATALAVFSTELMFRYVNSRQEANKWARHGIGRTPNGQSVAPSRWLRGWRRLNSGHGQLLGASTH 548
            ...|:.|...|..::   ||.||.:     :....|.|::.||         :|.:.|.......
Human   824 LGLAMLVALIEFCYK---SRAEAKR-----MKVAKNAQNINPS---------SSQNSQNFATYKE 871

  Fly   549 GQNV 552
            |.||
Human   872 GYNV 875

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.