DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir76b and GRIA1

DIOPT Version :9

Sequence 1:NP_649176.1 Gene:Ir76b / 40198 FlyBaseID:FBgn0036937 Length:636 Species:Drosophila melanogaster
Sequence 2:NP_001244950.1 Gene:GRIA1 / 2890 HGNCID:4571 Length:916 Species:Homo sapiens


Alignment Length:591 Identity:126/591 - (21%)
Similarity:216/591 - (36%) Gaps:135/591 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    62 TLETINRKKPKLREMLDW--------------IGGKHLRIATLEDFPLSYTEVLEN--------- 103
            ||..|..|...:|::..|              .||.:   :::::.....|.:||:         
Human   375 TLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDN---SSVQNRTYIVTTILEDPYVMLKKNA 436

  Fly   104 ----GTRVGHGVSFQIIDFLKKKFNFTYEVVVPQDNIIGSPSDFDRSLIEMVNS---STVDLAAA 161
                |.....|...::...:.|...::|.:.:..|...|:.....::...||..   ...|:|.|
Human   437 NQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVA 501

  Fly   162 FIPSLSDQRSFVYYSTTTLDEGEWIMVMQRPRESASG-SGLLAPFEFWVWILILVSLLAVGPIIY 225
            .:.....:...:.:|...:..|..||: ::|::|..| ...|.|..:.:|:.|:.:.:.|..:::
Human   502 PLTITLVREEVIDFSKPFMSLGISIMI-KKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLF 565

  Fly   226 ALIIL-------------RNRLTGDGQQTPYSLGHCAWFVYGALMKQGSTLSPIADSTRLLFATW 277
            .:...             |::.|.| |...:.:.:..||..||.|:||..:||.:.|.|::...|
Human   566 LVSRFSPYEWHSEEFEEGRDQTTSD-QSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVW 629

  Fly   278 WIFITILTSFYTANLTAFLTLSKFTLPYNTVNDIL--------------TK-----------NKH 317
            |.|..|:.|.|||||.||||:.:...|..:..|:.              ||           .|.
Human   630 WFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKM 694

  Fly   318 FVSMRGGGVEYAIRTTNESLSMLNRMIQNNYAVFSDETNDTYNLQNYVEKNGYVFVRDRPAINIM 382
            :..|:.......:|||.|.:..: |..:..||...:.|     :..|:|:        |...:.|
Human   695 WTYMKSAEPSVFVRTTEEGMIRV-RKSKGKYAYLLEST-----MNEYIEQ--------RKPCDTM 745

  Fly   383 LYRDYLYRKTVSFSDEKVHCPFAMAKEPFLKKKRTFAYPIGSNLSQLFDPELLHLVESGIVKHLS 447
                    |.....|.|.:               ..|.|.||.|....:..:|.|.|.|::..|.
Human   746 --------KVGGNLDSKGY---------------GIATPKGSALRNPVNLAVLKLNEQGLLDKLK 787

  Fly   448 KRNLPSAEICPQDLGGTERQLRNGDLMMT-----YYIMLAGFATALAVFSTELMFRYVNSRQEAN 507
            .:.......|..  ||.:.:.:...|.::     :||::.|...|:.|...|..::   ||.|:.
Human   788 NKWWYDKGECGS--GGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYK---SRSESK 847

  Fly   508 KWARHGIGRTPN---GQSVAPSRWLRGWRRLNSGHGQLLGASTHGQNVTP---PPPYQSI-FNGG 565
            :  ..|....|.   .:::..|...|     |||.|...|.|.....|..   |...||| ....
Human   848 R--MKGFCLIPQQSINEAIRTSTLPR-----NSGAGASSGGSGENGRVVSHDFPKSMQSIPCMSH 905

  Fly   566 SHGDPL 571
            |.|.||
Human   906 SSGMPL 911

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir76bNP_649176.1 Periplasmic_Binding_Protein_Type_2 83..437 CDD:304360 82/408 (20%)
GRIA1NP_001244950.1 PBP1_iGluR_AMPA_GluR1 36..399 CDD:107385 6/23 (26%)
ANF_receptor 47..382 CDD:279440 3/6 (50%)
PBP2_iGluR_AMPA_GluR1 416..797 CDD:270447 86/419 (21%)
Lig_chan 548..827 CDD:278489 69/318 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165155987
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1052
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR18966
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.840

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