Protein Alignment Ir76b and GRIA1

DIOPT Version :10

• Sequence 1: NP_649176.1
• Gene: Ir76b / 40198
• FlyBaseID: FBgn0036937
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_001244950.1
• Gene: GRIA1 / 2890
• HGNCID: 4571
• Length: 916
• Species: Homo sapiens
• Alignment Length: 591
• Identity: 126/591 - (21%)
• Similarity: 216/591 - (36%)
• Gaps: 135/591 - (22%)

  Fly    62 TLETINRKKPKLREMLDW--------------IGGKHLRIATLEDFPLSYTEVLEN--------- 103
            ||..|..|...:|::..|              .||.:   :::::.....|.:||:
Human   375 TLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDN---SSVQNRTYIVTTILEDPYVMLKKNA 436

  Fly   104 ----GTRVGHGVSFQIIDFLKKKFNFTYEVVVPQDNIIGSPSDFDRSLIEMVNS---STVDLAAA 161
                |.....|...::...:.|...::|.:.:..|...|:.....::...||..   ...|:|.|
Human   437 NQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVA 501

  Fly   162 FIPSLSDQRSFVYYSTTTLDEGEWIMVMQRPRESASG-SGLLAPFEFWVWILILVSLLAVGPIIY 225
            .:.....:...:.:|...:..|..||: ::|::|..| ...|.|..:.:|:.|:.:.:.|..:::
Human   502 PLTITLVREEVIDFSKPFMSLGISIMI-KKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLF 565

  Fly   226 ALIIL-------------RNRLTGDGQQTPYSLGHCAWFVYGALMKQGSTLSPIADSTRLLFATW 277
            .:...             |::.|.| |...:.:.:..||..||.|:||..:||.:.|.|::...|
Human   566 LVSRFSPYEWHSEEFEEGRDQTTSD-QSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVW 629

  Fly   278 WIFITILTSFYTANLTAFLTLSKFTLPYNTVNDIL--------------TK-----------NKH 317
            |.|..|:.|.|||||.||||:.:...|..:..|:.              ||           .|.
Human   630 WFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKM 694

  Fly   318 FVSMRGGGVEYAIRTTNESLSMLNRMIQNNYAVFSDETNDTYNLQNYVEKNGYVFVRDRPAINIM 382
            :..|:.......:|||.|.:..: |..:..||...:.|     :..|:|:        |...:.|
Human   695 WTYMKSAEPSVFVRTTEEGMIRV-RKSKGKYAYLLEST-----MNEYIEQ--------RKPCDTM 745

  Fly   383 LYRDYLYRKTVSFSDEKVHCPFAMAKEPFLKKKRTFAYPIGSNLSQLFDPELLHLVESGIVKHLS 447
                    |.....|.|.:               ..|.|.||.|....:..:|.|.|.|::..|.
Human   746 --------KVGGNLDSKGY---------------GIATPKGSALRNPVNLAVLKLNEQGLLDKLK 787

  Fly   448 KRNLPSAEICPQDLGGTERQLRNGDLMMT-----YYIMLAGFATALAVFSTELMFRYVNSRQEAN 507
            .:.......|..  ||.:.:.:...|.::     :||::.|...|:.|...|..::   ||.|:.
Human   788 NKWWYDKGECGS--GGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYK---SRSESK 847

  Fly   508 KWARHGIGRTPN---GQSVAPSRWLRGWRRLNSGHGQLLGASTHGQNVTP---PPPYQSI-FNGG 565
            :  ..|....|.   .:::..|...|     |||.|...|.|.....|..   |...||| ....
Human   848 R--MKGFCLIPQQSINEAIRTSTLPR-----NSGAGASSGGSGENGRVVSHDFPKSMQSIPCMSH 905

  Fly   566 SHGDPL 571
            |.|.||
Human   906 SSGMPL 911

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Lig_chan-Glu_bd	83..192	CDD:463166	18/124 (15%)
		Lig_chan	209..458	CDD:459656	63/286 (22%)
GRIA1	NP_001244950.1	PBP1_iGluR_AMPA_GluR1	36..402	CDD:380613	6/26 (23%)
		PBP2_iGluR_AMPA_GluR1	416..797	CDD:270447	86/419 (21%)