Protein Alignment Ir76b and Grin2c

DIOPT Version :10

• Sequence 1: NP_649176.1
• Gene: Ir76b / 40198
• FlyBaseID: FBgn0036937
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: XP_017452477.1
• Gene: Grin2c / 24411
• RGDID: 2739
• Length: 1250
• Species: Rattus norvegicus
• Alignment Length: 628
• Identity: 130/628 - (20%)
• Similarity: 220/628 - (35%)
• Gaps: 168/628 - (26%)

  Fly    68 RKKPKLREMLDWIGGKHLRIATLEDFPLSYTEVLENGT------------RVGH----------- 109
            |....|:.::|   .:||.:||||:.|....|..:.||            :..|
  Rat   402 RYSTSLQPVVD---SRHLTVATLEERPFVIVESPDPGTGGCVPNTVPCRRQSNHTFSSGDLTPYT 463

  Fly   110 -----GVSFQIIDFLKKKFNFTYEVVVPQDNIIGS-PSDFDRSLIEMVNSSTVDLAAAFIPSLSD 168
                 |....|:..|.|...|:|::.:..:...|. .......:|..|.....|:|...: ::::
  Rat   464 KLCCKGFCIDILKKLAKVVKFSYDLYLVTNGKHGKRVRGVWNGMIGEVYYKRADMAIGSL-TINE 527

  Fly   169 QRS-FVYYSTTTLDEGEWIMVMQRPRESASGSGLLAPFEFWVWILILVSLLAV-----------G 221
            :|| .:.:|...::.|..:|| .|...:.|.|..|.|:...||:::.|..|.|           .
  Rat   528 ERSEIIDFSVPFVETGISVMV-SRSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFS 591

  Fly   222 PIIYALIILRNRLTGDGQQTPYSLGHCAWFVYGALMKQGSTL-SPIADSTRLLFATWWIFITILT 285
            |:.|...:.:.:..|.   ..:::|...|.::..:......: :|...:::::...|..|..|..
  Rat   592 PVSYNQNLTKGKKPGG---PSFTIGKSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFL 653

  Fly   286 SFYTANLTAFLTLSKFTLPYNTVNDILTKN----------KHFVSMRGGGVEYAIRTTNESLSML 340
            :.|||||.||:...::   .:||:.:..|.          ..|.::..|..|..||:...  .|.
  Rat   654 ASYTANLAAFMIQEQY---IDTVSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYR--DMH 713

  Fly   341 NRMIQNNYAVFSDETNDTYNLQNYVEKNGYV--FVRDRPAINIMLYRDYLYRKTVSFSDEKVHCP 403
            ..|::.|.....|.....        |.|.:  |:.|...:|.|..:|. ..|.|:....||...
  Rat   714 THMVKFNQRSVEDALTSL--------KMGKLDAFIYDAAVLNYMAGKDE-GCKLVTIGSGKVFAT 769

  Fly   404 ----FAMAKEPFLKKKRTFAYPIGSNLSQLFDPELLHLVE---SGIVKHLSKRNLPSAEICPQDL 461
                .||.|:...|:....|.     |..|.|.|...|..   |||.:: .|..:.|:::...::
  Rat   770 TGYGIAMQKDSHWKRAIDLAL-----LQLLGDGETQKLETVWLSGICQN-EKNEVMSSKLDIDNM 828

  Fly   462 GGTERQLRNGDLMMTYYIMLAGFATALAVF----------------STELMFRYVNSRQEANKWA 510
            .|            .:|::|.....||.||                |::|.|....||
  Rat   829 AG------------VFYMLLVAMGLALLVFAWEHLVYWKLRHSVPNSSQLDFLLAFSR------- 874

  Fly   511 RHGIGRTPNGQSVAPS-------------------RWLRGWRRL------------------NSG 538
              ||....||....||                   :.|:..|.:                  |.|
  Rat   875 --GIYSCFNGVQSLPSPARPPSPDLTADSAQANVLKMLQAARDMVNTADVSSSLDRATRTIENWG 937

  Fly   539 HGQLLGASTHG--QNVTPPPPYQSIFNGGSHGDPLNRWRRPLA 579
            :.:.:.|.|..  ::.||.||.|...:|..   |....|.|||
  Rat   938 NNRRVPAPTASGPRSSTPGPPGQPSPSGWG---PPGGGRTPLA 977

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Lig_chan-Glu_bd	83..192	CDD:463166	28/138 (20%)
		Lig_chan	209..458	CDD:459656	59/279 (21%)
Grin2c	XP_017452477.1	PBP1_iGluR_NMDA_NR2	41..397	CDD:380601
		PBP2_iGluR_NMDA_Nr2	413..813	CDD:270436	90/423 (21%)
		NMDAR2_C	850..>925	CDD:463148	13/83 (16%)