Protein Alignment Ir76b and Grin1

DIOPT Version :10

• Sequence 1: NP_649176.1
• Gene: Ir76b / 40198
• FlyBaseID: FBgn0036937
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_001257531.1
• Gene: Grin1 / 24408
• RGDID: 2736
• Length: 959
• Species: Rattus norvegicus
• Alignment Length: 690
• Identity: 128/690 - (18%)
• Similarity: 237/690 - (34%)
• Gaps: 213/690 - (30%)

  Fly    47 VDASEAGFDADAPVETLETINRKK------------PKLREMLDWIGGK-----------HLRIA 88
            |:.:|.|....|....:...|||.            |..|::: |.||:           .|:|.
  Rat   359 VEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKII-WPGGETEKPRGYQMSTRLKIV 422

  Fly    89 TLEDFPLSYTE-VLENGT---------------------------------RVGHGVSFQIIDFL 119
            |:...|..|.: .:.:||                                 :..:|....::..|
  Rat   423 TIHQEPFVYVKPTMSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKL 487

  Fly   120 KKKFNFTYEVVVPQDNIIGSPSDFDRS-------LIEMVNSSTVDLAAAFIPSLSDQRSFVYYST 177
            .:..||||||.:..|...|:....:.|       ::..:.|...|:..|.:...:::..::.:|.
  Rat   488 ARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSK 552

  Fly   178 TTLDEGEWIMVMQR-PRESASGSGLLAPFEFWVWILILVSLLAVGPIIYALIILRNRLTGDG--- 238
            ....:|..|:|.:. ||.:.  ...:.||:..:|:|:.:|:..|..::|.|    :|.:..|
  Rat   553 PFKYQGLTILVKKEIPRSTL--DSFMQPFQSTLWLLVGLSVHVVAVMLYLL----DRFSPFGRFK 611

  Fly   239 ------QQTPYSLGHCAWFVYGALMKQG-STLSPIADSTRLLFATWWIFITILTSFYTANLTAFL 296
                  ::...:|....||.:|.|:..| ...:|.:.|.|:|...|..|..|:.:.|||||.|||
  Rat   612 VNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFL 676

  Fly   297 TLSKFTLPYNTVNDILTKNKH----FVSMRGGGVEYAIRTTNESLSMLNRMIQNNY--------- 348
            .|.:.......:||...:|..    :.:::...|:...|...|..:|...|.::||
  Rat   677 VLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQA 741

  Fly   349 -------------AVFSDETNDTYNLQNYVEKNGYVFVRDRPAINIMLYRDYLYRKTVSFSDEKV 400
                         ||...|.:...:|..    .|.:|.|.  ...|.:.:|..:::.||.|..|.
  Rat   742 VRDNKLHAFIWDSAVLEFEASQKCDLVT----TGELFFRS--GFGIGMRKDSPWKQNVSLSILKS 800

  Fly   401 HCPFAMAKEPFLKKKRTFAYPIGSNLSQLFDPELLHLVESGIVKHL-----------SKRNLPSA 454
            |                                     |:|.::.|           |:.|.| |
  Rat   801 H-------------------------------------ENGFMEDLDKTWVRYQECDSRSNAP-A 827

  Fly   455 EICPQDLGGTERQLRNGDLMMTYYIMLAGFATALAVFSTELMF-RYVNSRQEANKWARHGIGRTP 518
            .:..:::.|            .:.::..|....:.:...|:.: |:.::|::..:.|
  Rat   828 TLTFENMAG------------VFMLVAGGIVAGIFLIFIEIAYKRHKDARRKQMQLA-------- 872

  Fly   519 NGQSVAPSRWLRGWRRLNSGHGQLLGASTHGQNVTPPPPYQSIFNGGSHGDPLNRWRRPLANGNA 583
               ..|.:.|.:..:...||..:            |.|..::.|...:.....:..||..:...:
  Rat   873 ---FAAVNVWRKNLQDRKSGRAE------------PDPKKKATFRAITSTLASSFKRRRSSKDTS 922

  Fly   584 LGNGVLLGGDSEGGVRRLINGRDYMVFR----NPNGQSQL 619
            .|          ||...|.|.:|.::.|    ...||.||
  Rat   923 TG----------GGRGALQNQKDTVLPRRAIEREEGQLQL 952

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Lig_chan-Glu_bd	83..192	CDD:463166	25/161 (16%)
		Lig_chan	209..458	CDD:459656	61/295 (21%)
Grin1	NP_001257531.1	PBP1_iGluR_NMDA_NR1	25..404	CDD:380602	10/45 (22%)
		PBP2_iGluR_NMDA_Nr1	416..820	CDD:270437	86/452 (19%)
		CaM_bdg_C0	856..884	CDD:402271	5/38 (13%)