DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir76b and Grik4

DIOPT Version :10

Sequence 1:NP_649176.1 Gene:Ir76b / 40198 FlyBaseID:FBgn0036937 Length:636 Species:Drosophila melanogaster
Sequence 2:NP_036704.1 Gene:Grik4 / 24406 RGDID:2734 Length:956 Species:Rattus norvegicus


Alignment Length:513 Identity:125/513 - (24%)
Similarity:201/513 - (39%) Gaps:87/513 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    95 LSYTEVLEN-------------GTRVGHGVSFQIIDFLKKKFNFTYEVVVPQDNIIGSPSDFDRS 146
            |..|.:|||             |.....|....::..|.:...|.|::.:..|.:.|.| :.:.:
  Rat   418 LVVTTILENPYLMLKGNHQDMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVP-EANGT 481

  Fly   147 LIEMVN---SSTVDLAAAFIPSLSDQRSFVYYSTTTLDEGEWIMVMQRPRESASGSGLLAPFEFW 208
            ...||.   :...|||.|.:...:::...:.:|...:..|..|:..............|.||...
  Rat   482 WTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRRPGYFSFLDPFSPG 546

  Fly   209 VWILILVSLLAVGPIIYALIILRNRLTGDGQQTP--------------YSLGHCAWFVYGALMKQ 259
            ||:.:|::.|||..:::    |..|||.....:|              ||||:..||..|..|:|
  Rat   547 VWLFMLLAYLAVSCVLF----LVARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQ 607

  Fly   260 GSTLSPIADSTRLLFATWWIFITILTSFYTANLTAFLTLSKFTLPYNTVNDILTKNKHFVSMRGG 324
            |||::|.|.|||.:...||.|..|:.|.|||||.||||:.:..:|..:|:|:..:.         
  Rat   608 GSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPIESVDDLADQT--------- 663

  Fly   325 GVEYAIRTTNESLSMLNRMIQNNYAVFSDETNDTY-NLQNYV-EKNGYVFVRD-RPAINIMLYRD 386
            .:||.  |.:...||         ..|.:....|| .:.||: .|...|||:. ...|..:|..:
  Rat   664 AIEYG--TIHGGSSM---------TFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSN 717

  Fly   387 Y--LYRKTVSFSDEKVHCPFAMAKEPFLKKKRTFAYPIGSNLSQLFDPELLHLVESGIVKHLSKR 449
            |  |...|::....:.:|...........|......|:||.....||..:|.|.|:..::.| ||
  Rat   718 YAFLLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEIL-KR 781

  Fly   450 NLPSAEICPQDLGGTERQLRNGDLMMTYYIMLAGFATALAVFSTELMFRYVNSRQEANKWA---- 510
            .......||::.....:.|...::...:.:::.|.  .:|:|...|.|.:.....||::.:    
  Rat   782 KWWEGGKCPKEEDHRAKGLGMENIGGIFVVLICGL--IVAIFMAMLEFLWTLRHSEASEVSVCQE 844

  Fly   511 ------------------RHGIGRTPNGQSVAPSRWLRGWRRLNSGHGQLLGASTHGQ 550
                              |...|..|....|...|..||...|:  :|:|.||....|
  Rat   845 MMTELRSIILCQDNIHPRRRRSGGLPPQPPVLEERRPRGTATLS--NGKLCGAGEPDQ 900

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir76bNP_649176.1 Lig_chan-Glu_bd 83..192 CDD:463166 22/112 (20%)
Lig_chan 209..458 CDD:459656 77/267 (29%)
Grik4NP_036704.1 Periplasmic_Binding_Protein_type1 24..402 CDD:471960
PBP2_iGluR_kainate_KA1 415..785 CDD:270442 102/392 (26%)
QRL_CxxC_CxxC 863..927 CDD:469521 13/40 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 931..956
Blue background indicates that the domain is not in the aligned region.

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