Protein Alignment Ir76b and Grin3a

DIOPT Version :9

• Sequence 1: NP_649176.1
• Gene: Ir76b / 40198
• FlyBaseID: FBgn0036937
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_001263284.1
• Gene: Grin3a / 242443
• MGIID: 1933206
• Length: 1135
• Species: Mus musculus
• Alignment Length: 675
• Identity: 134/675 - (19%)
• Similarity: 222/675 - (32%)
• Gaps: 225/675 - (33%)

  Fly    70 KPKLREMLDWIGGK-------------------------HLRIATLEDFPLSYT-EVLENG---- 104
            ||....:..|.||:                         |||:.||.:.|..:| ||.:.|
Mouse   475 KPMWTRLGSWQGGRIVMDSGIWPEQAQRHKTHFHHPNKLHLRVVTLIEHPFVFTREVDDEGLCPA 539

  Fly   105 ---------------------------------TRVGHGVSFQIIDFLKKKFNFTYEVVVPQDNI 136
                                             .:..:|....:::.|.:..||.:::.:..|..
Mouse   540 GQLCLDPMTNDSSILDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGDGK 604

  Fly   137 IGS-PSDFDRSLIEMVNSSTVDLAAAFIPSLSDQRSFV------YYSTTTLDEGEWIMVMQRPRE 194
            .|: .:.....|:..:.|.|.::|.... |::..||.|      ::||:       :.::.|.|:
Mouse   605 YGAWKNGHWTGLVGDLLSGTANMAVTSF-SINTARSQVIDFTSPFFSTS-------LGILVRTRD 661

  Fly   195 SASGSG-LLAPFEFWVWILILVSLLAVGPIIYALIILRNRL----TGDGQQTPYSLGHCAWFVYG 254
            :|:..| .:.|..:.:|:.|.|: |.:..|...|...::..    .|..:...:|........|.
Mouse   662 TAAPIGAFMWPLHWTMWLGIFVA-LHITAIFLTLYEWKSPFGMTPKGRNRNKVFSFSSALNVCYA 725

  Fly   255 ALMKQGSTLSPIADST-RLLFATWWIFITILTSFYTANLTAFLTLSKFTLPYNTVNDILTKNKH- 317
            .|..:.:.:.|....| |.|...|.||.....|.|||||.|.:...|.   |..::.|.....|
Mouse   726 LLFGRTAAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKI---YEELSGIHDPKLHH 787

  Fly   318 ------FVSMRGGGVEYAIRTTNESLSMLNRMIQNNYAVFSDETNDTYNLQNYVEKNGYVFVRDR 376
                  |.::|....|..:|   :|...::..:: .|.|.:......| |:|..||.. .|:.|:
Mouse   788 PSQGFRFGTVRESSAEDYVR---QSFPEMHEYMR-RYNVPATPDGVQY-LKNDPEKLD-AFIMDK 846

  Fly   377 PAINIMLYRDYLYRKTVSFSDEKVHCPFAMAKEPFLKKKRTFAYPIG--------SNLSQLFDP- 432
            ..:      ||    .||...:   |......:||..:    .|.||        ||:|:|...
Mouse   847 ALL------DY----EVSIDAD---CKLLTVGKPFAIE----GYGIGLPPNSPLTSNISELISQY 894

  Fly   433 ------ELLH-----LVESGIVKHLSKRNLPSAEICPQDLGGTERQLRNGDLMMTYYIMLAGFA- 485
                  ::||     :|..|      ||:....|..         |:........:.::..||.
Mouse   895 KSHGFMDVLHDKWYKVVPCG------KRSFAVTETL---------QMGIKHFSGLFVLLCIGFGL 944

  Fly   486 TALAVFSTELMFR-----------------------------YVNSRQEANKWARHGIGRTPNGQ 521
            :.|......:::|                             :|..:|..:|..|
Mouse   945 SILTTIGEHIVYRLLLPRIKNKSKLQYWLHTSQRFHRALNTSFVEEKQPCSKTKR---------- 999

  Fly   522 SVAPSRWLRGWR-------------RLNSGHGQLLGASTHGQNVTPPPPYQSIFNG--------- 564
             |..||| |.|.             |.|.|..||:..:|  .|::.....:.|||.
Mouse  1000 -VEKSRW-RRWTCKTEGDSELSLFPRSNMGPQQLMVWNT--SNLSHDNQRKYIFNDEEGQNQLGT 1060

  Fly   565 GSHGD-PLNRWRRPL-----ANGNA 583
            .:|.| ||...||.|     .||.|
Mouse  1061 QTHQDIPLPPRRRELPASLTTNGKA 1085

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Periplasmic_Binding_Protein_Type_2	83..437	CDD:304360	89/456 (20%)
Grin3a	NP_001263284.1	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	5/21 (24%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	89/430 (21%)
		Lig_chan	676..942	CDD:278489	64/307 (21%)
		PPP2CB binding site. /evidence=ECO:0000250|UniProtKB:Q9R1M7	951..987		1/35 (3%)
		GIT1-binding. /evidence=ECO:0000250|UniProtKB:Q9R1M7	1082..1115		3/4 (75%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846421
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830