Protein Alignment Ir76b and Grin3a

DIOPT Version :10

• Sequence 1: NP_649176.1
• Gene: Ir76b / 40198
• FlyBaseID: FBgn0036937
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_612555.1
• Gene: Grin3a / 191573
• RGDID: 621704
• Length: 1135
• Species: Rattus norvegicus
• Alignment Length: 666
• Identity: 135/666 - (20%)
• Similarity: 227/666 - (34%)
• Gaps: 207/666 - (31%)

  Fly    70 KPKLREMLDWIGGK-------------------------HLRIATLEDFPLSYT-EVLENG---- 104
            ||....:..|.||:                         |||:.||.:.|..:| ||.:.|
  Rat   475 KPMWTRLGSWQGGRIVMDSGIWPEQAQRHKTHFQHPNKLHLRVVTLIEHPFVFTREVDDEGLCPA 539

  Fly   105 ---------------------------------TRVGHGVSFQIIDFLKKKFNFTYEVVVPQDNI 136
                                             .:..:|....:::.|.:..||.:::.:..|..
  Rat   540 GQLCLDPMTNDSSMLDRLFSSLHSSNDTVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGDGK 604

  Fly   137 IGS-PSDFDRSLIEMVNSSTVDLAAAFIPSLSDQRSFV------YYSTTTLDEGEWIMVMQRPRE 194
            .|: .:.....|:..:.|.|.::|.... |::..||.|      ::||:       :.::.|.|:
  Rat   605 YGAWKNGHWTGLVGDLLSGTANMAVTSF-SINTARSQVIDFTSPFFSTS-------LGILVRTRD 661

  Fly   195 SASGSG-LLAPFEFWVWILILVSLLAVGPIIYALIILRNRL----TGDGQQTPYSLGHCAWFVYG 254
            :|:..| .:.|..:.:|:.|.|: |.:..|...|...::..    .|..:...:|........|.
  Rat   662 TAAPIGAFMWPLHWTMWLGIFVA-LHITAIFLTLYEWKSPFGMTPKGRNRNKVFSFSSALNVCYA 725

  Fly   255 ALMKQGSTLSPIADST-RLLFATWWIFITILTSFYTANLTAFLTLSKFTLPYNTVNDILTKNKH- 317
            .|..:.:.:.|....| |.|...|.||.....|.|||||.|.:...|.   |..::.|.....|
  Rat   726 LLFGRTAAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKI---YEELSGIHDPKLHH 787

  Fly   318 ------FVSMRGGGVEYAIRTTNESLSMLNRMIQNNYAVFSDETNDTYNLQNYVEKNGYVFVRDR 376
                  |.::|....|..:|   :|...::..:: .|.|.:......| |:|..||.. .|:.|:
  Rat   788 PSQGFRFGTVRESSAEDYVR---QSFPEMHEYMR-RYNVPATPDGVQY-LKNDPEKLD-AFIMDK 846

  Fly   377 PAINIMLYRDYLYRKTVSFSDEKVHCPFAMAKEPFLKKKRTFAYPIG--------SNLSQLFDP- 432
            ..:      ||    .||...:   |......:||..:    .|.||        ||:|:|...
  Rat   847 ALL------DY----EVSIDAD---CKLLTVGKPFAIE----GYGIGLPPNSPLTSNISELISQY 894

  Fly   433 ------ELLH-----LVESGIVKHLSKRNLPSAEICPQDLGGTERQLRNGDLMMTYYIMLAGFAT 486
                  ::||     :|..|      ||:....|..         |:........:.::..||
  Rat   895 KSHGFMDVLHDKWYKVVPCG------KRSFAVTETL---------QMGIKHFSGLFVLLCIGF-- 942

  Fly   487 ALAVFST-------ELMFRYVNSRQEANKWAR-----HGIGRT-------PNGQS--VAPSRWLR 530
            .|::.:|       .|:...:.::.:...|..     |....|       |..::  |..||| |
  Rat   943 GLSILTTIGEHIVHRLLLPRIKNKSKLQYWLHTSQRFHRALNTSFVEEKQPRSKTKRVEKSRW-R 1006

  Fly   531 GWR-------------RLNSGHGQLLGASTHGQNVTPPPPYQSIFNG---------GSHGD-PLN 572
            .|.             |.|.|..||:..:|  .|::.....:.|||.         .:|.| ||.
  Rat  1007 RWTCKTEGDSELSLFPRSNLGPQQLMVWNT--SNLSHDNQRKYIFNDEEGQNQLGTQAHQDIPLP 1069

  Fly   573 RWRRPL-----ANGNA 583
            :.||.|     .||.|
  Rat  1070 QRRRELPASLTTNGKA 1085

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Lig_chan-Glu_bd	83..192	CDD:463166	26/178 (15%)
		Lig_chan	209..458	CDD:459656	63/280 (23%)
Grin3a	NP_612555.1	PBP1_iGluR_NMDA_NR3	40..496	CDD:380600	5/20 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	60..117
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	89/430 (21%)
		Lig_chan	674..941	CDD:459656	64/308 (21%)
		PPP2CB binding site. /evidence=ECO:0000269|PubMed:11588171	951..987		4/35 (11%)
		GIT1-binding. /evidence=ECO:0000269|PubMed:24297929	1082..1115		3/4 (75%)