DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir76b and glr-7

DIOPT Version :9

Sequence 1:	NP_649176.1	Gene:	Ir76b / 40198	FlyBaseID:	FBgn0036937	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_001337310.1	Gene:	glr-7 / 180547	WormBaseID:	WBGene00001618	Length:	885	Species:	Caenorhabditis elegans

Alignment Length:	541	Identity:	118/541 - (21%)
Similarity:	210/541 - (38%)	Gaps:	140/541 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 GVSFQIIDFLKKKFNFTYEVVVPQDNIIGSPSDFD--RSLIEMVNSSTVDLAAAFIPSLSDQRSF 172
            |....:|:.::.:.||||.:...:|...|:..|..  ..||..:.|.:.|:|.|.:..::::.:.
Worm   397 GYCIDLINMIQVEVNFTYTIYEVEDGSFGTMDDNGNWNGLIGALVSGSADIALAPLSVMAEREND 461

  Fly   173 VYYSTTTLDEGEWIMVMQRPRESASGSGLLAPFEFWVWILILVSLLAVGPII--------YALII 229
            |.::....|.....::|::.....|....:...|:.||:.|:.:.|....::        |:...
Worm   462 VDFTVPYYDLVGTTILMKKADVEYSLFKFMKVLEWPVWLCIVAAYLFTSILLWIFDRFSPYSFTN 526

  Fly   230 LRNRLTGDGQQTPYSLGHCAWFVYGALMKQGSTLSPIADSTRLLFATWWIFITILTSFYTANLTA 294
            .:.|...|.::..:||..|.||...:|..||...:|...|.||:.||||:|..|:.:.|||||.|
Worm   527 NKERYQNDIEKRQFSLKECLWFCMTSLTPQGGGEAPKNISGRLVAATWWLFGFIIIASYTANLAA 591

  Fly   295 FLTLSKFTLPYNTVNDILTKNK-HFVSMRGGGVEYAIR----------------TTNESLSMLNR 342
            |||:|:...|.::::|:..:.| .:..::|...|...|                :.|||:|..:|
Worm   592 FLTVSRLEQPISSLDDLAKQYKIEYAPIKGSASETYFRRMAEIEETFYNMWKEMSLNESMSPRDR 656

  Fly   343 MIQNNYAVFSDETNDTY-NLQNYVEK------------------NGYVFVRDRPAIN-IMLYRDY 387
            .   ..||:....:|.: |:..|:::                  :|:.|:.|...|. ..|....
Worm   657 A---KLAVWDYPVSDKFTNMWRYMQESKLPVNMDTAVDRVLNSVDGFAFIGDATEIKYAALTNCN 718

  Fly   388 LYRKTVSFSDEKVHCPFAMAKEP--FLKKKRTFAYPIGSNLSQLFDPELLHLVESGIVKHLSKRN 450
            |.:....||.:    |:|:|.:.  .||.|                      :.|.|:..|::|.
Worm   719 LQQVGTEFSRK----PYAIAVQSGHILKDK----------------------ISSAILMLLNERR 757

  Fly   451 L-----------PSAEICP-----------QDLGGTERQLRNGDLMMTYYIMLAGFATALAVFST 493
            |           |:...||           |::||            .:.::|||.|.::..
Worm   758 LETLKEKWWTDNPNKVSCPDSSDESDGISIQNIGG------------VFIVILAGIALSIVT--- 807

  Fly   494 ELMFRYVNSRQEANKWARHGIG--RTPNGQSVAPSRWLRGWRRLNSGHGQLLGASTHGQNVTPPP 556
             |.|.|...:::|.|.|.....  .....|.|.|:                 |..|:|.....|
Worm   808 -LAFEYYYYKRKARKAAEKEQEELEMKQSQQVVPN-----------------GFHTNGVKQDAP- 853

  Fly   557 PYQSIFNG-GSHGDPLNRWRR 576
               .:.|| .::|:...|.:|
Worm   854 ---KLTNGTKTNGNTFRRTKR 871

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Periplasmic_Binding_Protein_Type_2	83..437	CDD:304360	85/375 (23%)
glr-7	NP_001337310.1	Periplasmic_Binding_Protein_Type_1	<102..>220	CDD:324556
glr-7	NP_001337310.1	PBP2_iGluR_putative	373..767	CDD:270435	90/398 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810