DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir76b and glr-2

DIOPT Version :10

Sequence 1:NP_649176.1 Gene:Ir76b / 40198 FlyBaseID:FBgn0036937 Length:636 Species:Drosophila melanogaster
Sequence 2:NP_001021114.1 Gene:glr-2 / 175999 WormBaseID:WBGene00001613 Length:977 Species:Caenorhabditis elegans


Alignment Length:517 Identity:118/517 - (22%)
Similarity:185/517 - (35%) Gaps:135/517 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   110 GVSFQIIDFLKKKF-NFTYEVVVPQDNIIGS---PSDFDRSLIEMVNSSTVDLAAAFIPSLSDQR 170
            |....:::.|.|.. .|.|:|.:...|..||   ...:| .:|..:.:.|.|:|.|.:....::.
 Worm   520 GYCIDLLNLLAKNITGFEYDVFISDGNKYGSRQADGSWD-GMIGYLLNETADVAVAPLTITQERE 583

  Fly   171 SFVYYSTTTLDEGEWIMVMQRPRESASGSGLLAPFEFWVWILILVSLLAVGPIIY---------- 225
            ..|.:|...:..|..||:.:..::..:....:.|....:||..|.|...|...|:          
 Worm   584 RAVDFSKPFMTTGISIMIKKPEKQEFNIFSFMEPLGMTIWIFTLSSYFGVSLTIFLVSWFSPYEK 648

  Fly   226 ALIILRNRLTGDGQQTPYSLGHCAWFVYGALMKQGSTLSPIADSTRLLFATWWIFITILTSFYTA 290
            .:...|...|...:.|.|   :..||...|.|:||:.:.|.|.|.|:..:.||.|..|:.|.|||
 Worm   649 RIEFKRGEFTVTNEFTLY---NSLWFTLAAFMQQGTDILPRAVSGRIASSCWWFFTLIIVSSYTA 710

  Fly   291 NLTAFLTLSKFTLPYNTVNDILTKNKHFVSMRGGGV-----------------EYAIRTTNESLS 338
            ||.|||||.:.|.|..:|.|:..:||....:..||.                 .:.:.||.:.:.
 Worm   711 NLAAFLTLERMTPPIESVEDLANQNKILYGVNEGGSTAAFFEDSIVPLYKKMWNFMVSTTQKQIE 775

  Fly   339 MLNRMIQNNYAVFSDETNDTYNLQNYVEKNGYVFVRDRPAINIMLYRDYLYRKTVSFSD--EKVH 401
            :..:.|          ||.|.|         .:||.                   |::|  |||.
 Worm   776 LEKQSI----------TNSTSN---------RIFVS-------------------SYADGIEKVR 802

  Fly   402 CPFAMAKEPFLKKKRTFAY----------PIGSNLSQL---------------FDPELLHLVESG 441
            .  :..|..||.::.|..|          .:|.||:.|               .:..:|:|.|.|
 Worm   803 T--SKGKYAFLLEETTNNYESGRRPCDTMKVGQNLNTLGYGIATKIGNPLRVSLNLAILYLSEKG 865

  Fly   442 IVKHLSKRNLPSAEICPQDL--GGTERQLRNGDLMMTYYIMLAGFATALAVFSTELMFR--YVNS 502
            .:|.|..:.......|....  |||...|....:...:||:|||...::.....|.:||  ..|.
 Worm   866 ELKKLENKWWYDRGQCDTGTSDGGTSSSLNLSKVAGIFYILLAGMVLSMCTALVEFLFRKNKENR 930

  Fly   503 RQEANKWARHGIGRTPNGQSVAPSRWLRGWRRLNSG---------HGQLLGASTHGQNVTPP 555
            .:|.|:                    :|..|.|..|         ..||....|..:.|:.|
 Worm   931 EKERNR--------------------MRSSRPLKPGILASCERAKQKQLQNRRTKSEEVSTP 972

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir76bNP_649176.1 Lig_chan-Glu_bd 83..192 CDD:463166 20/85 (24%)
Lig_chan 209..458 CDD:459656 72/302 (24%)
glr-2NP_001021114.1 PBP1_iGluR_AMPA 24..460 CDD:380603
Periplasmic_Binding_Protein_Type_2 491..875 CDD:473866 93/398 (23%)
Blue background indicates that the domain is not in the aligned region.

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