DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir76b and glr-3

DIOPT Version :9

Sequence 1:	NP_649176.1	Gene:	Ir76b / 40198	FlyBaseID:	FBgn0036937	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_492017.3	Gene:	glr-3 / 172449	WormBaseID:	WBGene00001614	Length:	836	Species:	Caenorhabditis elegans

Alignment Length:	474	Identity:	112/474 - (23%)
Similarity:	194/474 - (40%)	Gaps:	67/474 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 GKHLRIATLEDFPLSYTEVLENGTRVGHGVSFQIIDFLKKKFN---FTYEVVVPQDNIIGSPSDF 143
            ||||:|:...:.|  :..:..||:..|:     .||.|.|..|   |||.:...:||..||....
Worm   400 GKHLKISVYLEAP--FVMITSNGSYEGY-----CIDLLHKIANILKFTYTIQKVRDNAYGSKESN 457

  Fly   144 DR--SLIEMVNSSTVDLAAAFIPSLSDQRSFVYYSTTTLDEGEWIMVMQRPR-ESASGSGLLAPF 205
            .:  .::..:.....|||.|.: ::|..||.|...|.........::.::|| ..:.....:.|.
Worm   458 GKWSGMVGELQRGDADLAVASL-TISYGRSEVIDFTVPYMHLGISILFKKPRIRDSDWFKFMDPL 521

  Fly   206 EFWVWILILVSLLAVGPIIYALIILR-----NRLTGDGQQTP----YSLGHCAWFVYGALMKQGS 261
            ...|||:...|...|...|:.:..:.     .|...:||..|    :||.:..||...:||:|||
Worm   522 STQVWIMTFASYFVVSVAIWIIAKISPYEQFERDEDNGQYKPVDNQFSLRNSFWFTVCSLMQQGS 586

  Fly   262 TLSPIADSTRLLFATWWIFITILTSFYTANLTAFLTLSKFTLPYNTVNDIL--TKNKHFVSMRGG 324
            .|.|.|.|||||...||.|..||.|.|||||.|.||..:...|....:|:.  ||.|:....||.
Worm   587 ELCPRAASTRLLTGIWWFFALILISSYTANLAAVLTTRRMETPIENADDLAAQTKIKYGTLGRGS 651

  Fly   325 GVEYAIRTTNESLSMLNRMIQNNYAVFSDETNDTYNLQNYVEKNGYVFVRDRPAINIMLYRDYLY 389
            .:.:...:..|:...:.:::.::..:|...:.:..   ..|:.:.|.::.:...:...:.||...
Worm   652 TMSFFNESKIETYERMWQLMSSSPGLFVQSSKEGI---ARVKSSDYAYLMESSMLEYAVERDCEL 713

  Fly   390 RKTVSFSDEKVHCPFAMAKEPFLKKKRTFAYPIGSNLSQLFDPELLHLVESGIVKHLSKR-NLPS 453
            .:.....|:|.:               ....|.||...:|....:|.|.|...:..|.:: ....
Worm   714 MQIGGLIDQKGY---------------GIGLPKGSPYRELISTAILRLQEKTELTELKEKWWKDK 763

  Fly   454 AEICPQDLGGTERQLRNGDLMMTYYIMLAGFATALAVFSTELMFRYVNSRQEA---NKWARHGIG 515
            :.:|.|.   ..:...:|:.:...:|:|   ...|.:.:..::|..:.:|:.:   ::..||
Worm   764 SVVCEQP---KRKDQDDGESIGGIFIIL---VVGLVLTAVLVIFELITTRKPSPAQSQVIRH--- 819

  Fly   516 RTPNGQSVAPS------RW 528
                 .:|.||      ||
Worm   820 -----VNVIPSFKLGFFRW 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Periplasmic_Binding_Protein_Type_2	83..437	CDD:304360	93/370 (25%)
glr-3	NP_492017.3	PBP1_iGluR_non_NMDA-like	21..385	CDD:380591
glr-3	NP_492017.3	Periplasmic_Binding_Protein_Type_2	401..761	CDD:419667	96/385 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910