Protein Alignment Ir76b and Grin3b

DIOPT Version :10

• Sequence 1: NP_649176.1
• Gene: Ir76b / 40198
• FlyBaseID: FBgn0036937
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_579842.2
• Gene: Grin3b / 170796
• RGDID: 621705
• Length: 1002
• Species: Rattus norvegicus
• Alignment Length: 701
• Identity: 134/701 - (19%)
• Similarity: 217/701 - (30%)
• Gaps: 265/701 - (37%)

  Fly    45 MDVDASEAGFDADAPVETLETINRKKPKLREMLDWIGGKHLRIATLEDFPLSYTE---------- 99
            :|.....|.....:|..|     :.:||            ||:.||.:.|..:|.
  Rat   394 LDFQPGAAALRVPSPSGT-----QARPK------------LRVVTLVEHPFVFTRESDEDGQCPA 441

  Fly   100 --------------------VLENGT------RVGHGVSFQIIDFLKKKFNFTYEVVVPQDNIIG 138
                                .|.||:      |..:|....:::.|.:...|.:|:.:..|...|
  Rat   442 GQLCLDPGTNDSARLDALFAALVNGSVPRTLRRCCYGYCIDLLERLAEDLAFDFELYIVGDGKYG 506

  Fly   139 SPSDFD-RSLIEMVNSSTVDLAAAFIPSLSDQRSFV------YYSTTTLDEGEWIMVMQRPRESA 196
            :..|.. ..|:..:.:....:|.... |::..||.|      ::||:       :.:|.|.|::|
  Rat   507 ALRDGRWTGLVGDLLAGRAHMAVTSF-SINSARSQVVDFTSPFFSTS-------LGIMVRTRDTA 563

  Fly   197 SGSG-LLAPFEFWVWILILVSLLAVGPIIYALIIL--------------RNRLTGDGQQTPYS-- 244
            |..| .:.|..:.:|:.:..:|     .:.||.:.              |||    |....||
  Rat   564 SPIGAFMWPLHWSMWVGVFAAL-----HLTALFLTLYEWRSPYGLTPRGRNR----GTVFSYSSA 619

  Fly   245 LGHCAWFVYGALMKQGSTLSPIADSTRLLFATWWIFITILTSFYTANLTAFLTLSKFTLPYNTVN 309
            |..|...::|..:   |:.:|...:.|.|...|.||..::.|.|||||.|.:...|.....:.::
  Rat   620 LNLCYAILFGRTV---SSKTPKCPTGRFLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIH 681

  Fly   310 DILTKNKH----------------------FVSMRGGGVEYAIRTTNESLSMLNRMIQNNYAVFS 352
            |  .|..|                      |..|......::..||...::||
  Rat   682 D--PKLHHPSQGFRFGTVWESSAEAYIKASFPEMHAHMRRHSAPTTPHGVAML------------ 732

  Fly   353 DETNDTYNLQNYVEKNGYVFVRDRPAINIMLYRDYLYRKTVSFSDEKVHCPFAMAKEPFLKKKRT 417
              |:|...|.        .|:.|:..:      ||    .||...:   |......:||..:
  Rat   733 --TSDPPKLN--------AFIMDKSLL------DY----EVSIDAD---CKLLTVGKPFAIE--- 771

  Fly   418 FAYPIG--------SNLSQLFDPELLHLVESGIVKHLSK---RNLPSAEICPQDLGGTERQLRNG 471
             .|.||        ||||:.    :.....||.:..|..   :.:|    |.:.:......|:.|
  Rat   772 -GYGIGLPQNSPLTSNLSEF----ISRYKSSGFIDLLHDKWYKMVP----CGKRVFAVTETLQMG 827

  Fly   472 DLMMT--YYIMLAGFATALAV-FSTELMFRYVNSR-QEANKWARHGIGRTPNGQSVAPSRWLRGW 532
            ....:  :.::..|..:||.. ....:.:|.|..| :..||                    |:.|
  Rat   828 VYHFSGLFVLLCLGLGSALLTSLGEHVFYRLVLPRIRRGNK--------------------LQYW 872

  Fly   533 --------RRLNSGHGQLLGASTHGQNVTPPPPYQSIFNGGSHG--------DPLNRWRRP---- 577
                    |.||:|               ||...|........|        |...||||.
  Rat   873 LHTSQKIHRALNTG---------------PPEGQQERAEQERSGPKDELPATDGAGRWRRVRRAV 922

  Fly   578 ---------LANGNALGNGVLLGGDSEGGVRRLINGRDYMVFRNPNGQSQL 619
                     |..|.|       |||           |.::....|..|::|
  Rat   923 ERERRVRFLLEPGEA-------GGD-----------RPWLCSNGPGLQAEL 955

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Lig_chan-Glu_bd	83..192	CDD:463166	26/151 (17%)
		Lig_chan	209..458	CDD:459656	60/297 (20%)
Grin3b	NP_579842.2	PBP1_iGluR_NMDA_NR3	19..401	CDD:380600	1/6 (17%)
		PBP2_iGluR_NMDA_Nr3	414..808	CDD:270438	93/470 (20%)
		Lig_chan	574..841	CDD:459656	63/327 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	882..910		7/42 (17%)
		Involved in the trafficking and surface expression of NMDARs. /evidence=ECO:0000250|UniProtKB:Q91ZU9	951..984		2/5 (40%)