Protein Alignment Ir76b and Grin3b

DIOPT Version :10

• Sequence 1: NP_649176.1
• Gene: Ir76b / 40198
• FlyBaseID: FBgn0036937
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: XP_006513350.1
• Gene: Grin3b / 170483
• MGIID: 2150393
• Length: 1138
• Species: Mus musculus
• Alignment Length: 671
• Identity: 138/671 - (20%)
• Similarity: 219/671 - (32%)
• Gaps: 231/671 - (34%)

  Fly    45 MDVDASEAGFDADAPVETLETINRKKPKLREMLDWIGGKHLRIATLEDFPLSYTE---------- 99
            :|.....|.....:|..|     :.:||            ||:.||.:.|..:|.
Mouse   474 LDFQPGAAALRVPSPSGT-----QARPK------------LRVVTLVEHPFVFTRESDEDGQCPA 521

  Fly   100 --------------------VLENGT------RVGHGVSFQIIDFLKKKFNFTYEVVVPQDNIIG 138
                                .||||:      |..:|....:::.|.:...|.:|:.:..|...|
Mouse   522 GQLCLDPGTNDSARLDALFTALENGSVPRTLRRCCYGYCIDLLERLAEDLAFDFELYIVGDGKYG 586

  Fly   139 SPSDFD-RSLIEMVNSSTVDLAAAFIPSLSDQRSFV------YYSTTTLDEGEWIMVMQRPRESA 196
            :..|.. ..|:..:.:....:|.... |::..||.|      ::||:       :.:|.|.|::|
Mouse   587 ALRDGRWTGLVGDLLAGRAHMAVTSF-SINSARSQVVDFTSPFFSTS-------LGIMVRTRDTA 643

  Fly   197 SGSG-LLAPFEFWVWILILVSLLAVGPIIYALIIL--------------RNRLTGDGQQTPYS-- 244
            |..| .:.|..:.:|:.:..:|     .:.||.:.              |||    |....||
Mouse   644 SPIGAFMWPLHWSMWVGVFAAL-----HLTALFLTLYEWRSPYGLTPRGRNR----GTVFSYSSA 699

  Fly   245 LGHCAWFVYGALMKQGSTLSPIADSTRLLFATWWIFITILTSFYTANLTAFLTLSKFTLPYNTVN 309
            |..|...::|..:   |:.:|...:.|.|...|.||..::.|.|||||.|.:...|.....:.::
Mouse   700 LNLCYAILFGRTV---SSKTPKCPTGRFLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIH 761

  Fly   310 DILTKNKH----------------------FVSMRGGGVEYAIRTTNESLSMLNRMIQNNYAVFS 352
            |  .|..|                      |..|......::..||...::||
Mouse   762 D--PKLHHPSQGFRFGTVWESSAEAYIKASFPEMHAHMRRHSAPTTPHGVAML------------ 812

  Fly   353 DETNDTYNLQNYVEKNGYVFVRDRPAINIMLYRDYLYRKTVSFSDEKVHCPFAMAKEPFLKKKRT 417
              |:|...|.        .|:.|:..:      ||    .||...:   |......:||..:
Mouse   813 --TSDPPKLN--------AFIMDKSLL------DY----EVSIDAD---CKLLTVGKPFAIE--- 851

  Fly   418 FAYPIG--------SNLSQLFDPELLHLVESGIVKHLSK---RNLPSAEICPQDLGGTERQLRNG 471
             .|.||        ||||:.    :.....||.:..|..   :.:|    |.:.:......|:.|
Mouse   852 -GYGIGLPQNSPLTSNLSEF----ISRYKSSGFIDLLHDKWYKMVP----CGKRVFAVTETLQMG 907

  Fly   472 --DLMMTYYIMLAGFATALAV-FSTELMFRYVNSR-QEANK---W-------ARHGIGR------ 516
              .|...:.::..|..:||.. ....:.:|.|..| :..||   |       .:..:||
Mouse   908 VYHLSGLFVLLCLGLGSALLTSLGEHVFYRLVLPRIRRGNKLQYWLHTSQVRRQDKVGRGGGHLR 972

  Fly   517 -TPNGQSV----APSRWLRGWR----------RLNSGHGQLLGASTHG-------QNVTPPPPYQ 559
             .|...||    .||...|..|          ::.:|.|   ||...|       |.|.|||...
Mouse   973 SLPKHLSVPLEDPPSPQHRATRGATGEGRAGVQVTTGRG---GAGQSGVPGLASRQAVLPPPLRP 1034

  Fly   560 SIFNGGSHGDP----LNRWRR 576
            |   |.....|    ..||||
Mouse  1035 S---GPKEEQPAADGAGRWRR 1052

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Lig_chan-Glu_bd	83..192	CDD:463166	27/151 (18%)
		Lig_chan	209..458	CDD:459656	60/297 (20%)
Grin3b	XP_006513350.1	PBP1_iGluR_NMDA_NR3	141..481	CDD:380600	1/6 (17%)
		PBP2_iGluR_NMDA_Nr3	494..888	CDD:270438	94/470 (20%)
		Lig_chan	654..921	CDD:459656	64/327 (20%)