DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir76b and Grin2c

DIOPT Version :9

Sequence 1:	NP_649176.1	Gene:	Ir76b / 40198	FlyBaseID:	FBgn0036937	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	XP_017169765.1	Gene:	Grin2c / 14813	MGIID:	95822	Length:	1307	Species:	Mus musculus

Alignment Length:	690	Identity:	138/690 - (20%)
Similarity:	234/690 - (33%)	Gaps:	196/690 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 GTLSP-----------VTELPMDVDASEAGFDADAPVETLETINRKKPKLREMLD---------- 78
            |.:||           ||....|...|..|:... |...:..:||.  :|.||:.
Mouse   384 GPVSPAREAFYRHLLNVTWEGRDFSFSPGGYLVQ-PTMVVIALNRH--RLWEMVGRWDHGVLYMK 445

  Fly    79 ---W----------IGGKHLRIATLEDFPLSYTEVLENGT------------RVGH--------- 109
               |          :..:||.:||||:.|....|..:.||            :..|
Mouse   446 YPVWPRYSTSLQPVVDSRHLTVATLEERPFVIVESPDPGTGGCVPNTVPCRRQSNHTFSSGDITP 510

  Fly   110 -------GVSFQIIDFLKKKFNFTYEVVVPQDNIIGS-PSDFDRSLIEMVNSSTVDLAAAFIPSL 166
                   |....|:..|.|...|:|::.:..:...|. .......:|..|.....|:|...: ::
Mouse   511 YTKLCCKGFCIDILKKLAKVVKFSYDLYLVTNGKHGKRVRGVWNGMIGEVYYKRADMAIGSL-TI 574

  Fly   167 SDQRS-FVYYSTTTLDEGEWIMVMQRPRESASGSGLLAPFEFWVWILILVSLLAV---------- 220
            :::|| .:.:|...::.|..:|| .|...:.|.|..|.|:...||:::.|..|.|
Mouse   575 NEERSEIIDFSVPFVETGISVMV-ARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEY 638

  Fly   221 -GPIIYALIILRNRLTGDGQQTPYSLGHCAWFVYGALMKQGSTL-SPIADSTRLLFATWWIFITI 283
             .|:.|...:.:.:.:|.   ..:::|...|.::..:......: :|...:::::...|..|..|
Mouse   639 FSPVSYNQNLTKGKKSGG---PSFTIGKSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVI 700

  Fly   284 LTSFYTANLTAFLTLSKFTLPYNTVNDILTKN----------KHFVSMRGGGVEYAIRTTNESLS 338
            ..:.|||||.||:...::   .:||:.:..|.          ..|.::..|..|..||:...  .
Mouse   701 FLASYTANLAAFMIQEQY---IDTVSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYR--D 760

  Fly   339 MLNRMIQNNYAVFSDETNDTYNLQNYVEKNGYVFVRDRPAINIMLYRDYLYRKTVSFSDEKVHCP 403
            |...|::.|.....|..........:|.:....|:.|...:|.|..:|. ..|.|:....||...
Mouse   761 MHTHMVKFNQRSVEDALTSLKMGARHVSRKLDAFIYDAAVLNYMAGKDE-GCKLVTIGSGKVFAT 824

  Fly   404 ----FAMAKEPFLKKKRTFAYP--IGSNLSQLFDPELLHLVESGIVKHLSKRNLPSAEICPQDLG 462
                .||.|:...|:....|..  :|...:|..:...|    |||. |..|..:.|:::...::.
Mouse   825 TGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWL----SGIC-HNEKNEVMSSKLDIDNMA 884

  Fly   463 GTERQLRNGDLMMTYYIMLAGFATALAVF----------------STELMFRYVNSRQEANKWAR 511
            |            .:|::|.....||.||                |::|.|....||
Mouse   885 G------------VFYMLLVAMGLALLVFAWEHLVYWKLRHSVPSSSQLDFLLAFSR-------- 929

  Fly   512 HGIGRTPNGQSVAPS-------------------RWLRGWRRL------------------NSGH 539
             ||....||....||                   :.|:..|.:                  |.|:
Mouse   930 -GIYSCFNGVQSLPSPARPPSPDLTAGSAQANVLKMLQAARDMVSTADVSGSLDRATRTIENWGN 993

  Fly   540 GQLLGASTHG--QNVTPPPPYQSIFNGGSHGDPLNRWRRP 577
            .:...|.|..  ::.||.||.|...:|         ||.|
Mouse   994 NRRAPAPTTSGPRSCTPGPPGQPSPSG---------WRPP 1024

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Periplasmic_Binding_Protein_Type_2	83..437	CDD:304360	84/411 (20%)
Grin2c	XP_017169765.1	PBP1_iGluR_NMDA_NR2	90..446	CDD:380601	14/64 (22%)
		PBP2_iGluR_NMDA_Nr2	462..868	CDD:270436	87/421 (21%)
		NMDAR2_C	905..>980	CDD:371139	13/83 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846433
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740