Protein Alignment Ir76b and Grin2b

DIOPT Version :10

• Sequence 1: NP_649176.1
• Gene: Ir76b / 40198
• FlyBaseID: FBgn0036937
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_032197.3
• Gene: Grin2b / 14812
• MGIID: 95821
• Length: 1482
• Species: Mus musculus
• Alignment Length: 503
• Identity: 120/503 - (23%)
• Similarity: 196/503 - (38%)
• Gaps: 126/503 - (25%)

  Fly    68 RKKPKLREMLDWIGGKHLRIATLEDFPLSYTEVLE--NGTRVGHGVSFQ---------------- 114
            |..|:..|..|    .||.|.|||:.|....|.::  :||.:.:.|..|
Mouse   393 RMCPETEEQED----DHLSIVTLEEAPFVIVESVDPLSGTCMRNTVPCQKRIISENKTDEEPGYI 453

  Fly   115 -------IIDFLK---KKFNFTYEVVVPQDNIIGSPSDFDRSLIEMVNSSTVDLAAAFIPSL--S 167
                   .||.||   |...|||::.:..:...|  ...:.:...|:....:..|...:.||  :
Mouse   454 KKCCKGFCIDILKKISKSVKFTYDLYLVTNGKHG--KKINGTWNGMIGEVVMKRAYMAVGSLTIN 516

  Fly   168 DQRS-FVYYSTTTLDEGEWIMVMQRPRESASGSGLLAPFEFWVWILILVSLLAVGPIIYALIILR 231
            ::|| .|.:|...::.|..:|| .|...:.|.|..|.||...||:::.|.||.|..:  |:.:..
Mouse   517 EERSEVVDFSVPFIETGISVMV-SRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAV--AVFVFE 578

  Fly   232 -------NRLTGDGQQ---TPYSLGHCAWFVYGALMKQGSTL-SPIADSTRLLFATWWIFITILT 285
                   ||...||::   ..:::|...|.::|.:......: :|...:::::.:.|..|..|..
Mouse   579 YFSPVGYNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFL 643

  Fly   286 SFYTANLTAF------------LTLSKFTLPYNTVNDILTKNKHFVSMRGGGVEYAIRTTNESLS 338
            :.|||||.||            |:..||..|    || .:....|.::..|..|
Mouse   644 ASYTANLAAFMIQEEYVDQVSGLSDKKFQRP----ND-FSPPFRFGTVPNGSTE----------- 692

  Fly   339 MLNRMIQNNYA---VFSDETNDTYNLQNYVE------KNGYV--FVRDRPAINIMLYRDYLYRKT 392
               |.|:||||   .:..:.|     |..|:      |.|.:  |:.|...:|.|..||. ..|.
Mouse   693 ---RNIRNNYAEMHAYMGKFN-----QRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDE-GCKL 748

  Fly   393 VSFSDEKVHCP----FAMAKEPFLKKKRTFAYPIGSNLSQLFD----PELLHLVESGIVKHLSKR 449
            |:....||...    .|:.|:...|::...|      :.|||.    .||..|..:||. |..|.
Mouse   749 VTIGSGKVFASTGYGIAIQKDSGWKRQVDLA------ILQLFGDGEMEELEALWLTGIC-HNEKN 806

  Fly   450 NLPSAEICPQDLGGTERQLRNGDLMMTYYIMLAGFATALAVFSTELMF 497
            .:.|:::...::.|            .:|::.|..|.:|..|..|.:|
Mouse   807 EVMSSQLDIDNMAG------------VFYMLGAAMALSLITFICEHLF 842

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Lig_chan-Glu_bd	83..192	CDD:463166	32/139 (23%)
		Lig_chan	209..458	CDD:459656	70/290 (24%)
Grin2b	NP_032197.3	PBP1_iGluR_NMDA_NR2	33..388	CDD:380601
		PBP2_iGluR_NMDA_Nr2	403..803	CDD:270436	106/440 (24%)
		NMDAR2_C	840..1482	CDD:463148	1/3 (33%)