Protein Alignment Ir76b and Grin2a

DIOPT Version :10

• Sequence 1: NP_649176.1
• Gene: Ir76b / 40198
• FlyBaseID: FBgn0036937
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_032196.2
• Gene: Grin2a / 14811
• MGIID: 95820
• Length: 1464
• Species: Mus musculus
• Alignment Length: 492
• Identity: 105/492 - (21%)
• Similarity: 183/492 - (37%)
• Gaps: 133/492 - (27%)

  Fly    84 HLRIATLEDFPLSYTEVLE--------------------NGTRVG-------HGVSFQIIDFLKK 121
            ||.|.|||:.|....|.::                    |.|..|       .|....|:..|.:
Mouse   405 HLSIVTLEEAPFVIVEDIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSR 469

  Fly   122 KFNFTYEVVVPQDNIIGSPSD--FDRSLIEMVNSSTVDLAAAFIPSLSDQRS-FVYYSTTTLDEG 183
            ...|||::.:..:...|...:  ::..:.|:|....|....:.  :::::|| .|.:|...::.|
Mouse   470 TVKFTYDLYLVTNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSL--TINEERSEVVDFSVPFVETG 532

  Fly   184 EWIMVMQRPRESASGSGLLAPFEFWVWILILVSLLAVGPIIYALIIL---------RNRLTGDGQ 239
            ..:|| .|...:.|.|..|.||...||:::.|.||.|..|  |:.:.         ||...|...
Mouse   533 ISVMV-SRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAI--AVFVFEYFSPVGYNRNLAKGKAP 594

  Fly   240 QTP-YSLGHCAWFVYGALMKQGSTL-SPIADSTRLLFATWWIFITILTSFYTANLTAFLTLSKFT 302
            ..| :::|...|.::|.:......: :|...:::::.:.|..|..|..:.|||||.||:...:|.
Mouse   595 HGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFV 659

  Fly   303 LPYNTVNDILTKNKH-------FVSMRGGGVEYAIRTTNESLSMLNRMIQNNYAVFSDETNDTYN 360
            .....::|...:..|       |.::..|..|              |.|:|||. :..:....:|
Mouse   660 DQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTE--------------RNIRNNYP-YMHQYMTKFN 709

  Fly   361 LQNYVE------KNGYV--FVRDRPAINIMLYRD-----------YLYRKTVSFSDEKVHCPFAM 406
             |..||      |.|.:  |:.|...:|....||           |::..|          .:.:
Mouse   710 -QRGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATT----------GYGI 763

  Fly   407 AKEPFLKKKRTFAYPIGSNLSQLFDPELLHLVESGIVK-----------HLSKRNLPSAEICPQD 460
            |    |:|        ||...:..|..||..|..|.::           |..|..:.|:::...:
Mouse   764 A----LQK--------GSPWKRQIDLALLQFVGDGEMEELETLWLTGICHNEKNEVMSSQLDIDN 816

  Fly   461 LGGTERQLRNGDLMMTYYIMLAGFATALAVFSTELMF 497
            :.|            .:|::.|..|.:|..|..|.:|
Mouse   817 MAG------------VFYMLAAAMALSLITFIWEHLF 841

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Lig_chan-Glu_bd	83..192	CDD:463166	28/137 (20%)
		Lig_chan	209..458	CDD:459656	63/296 (21%)
Grin2a	NP_032196.2	PBP1_iGluR_NMDA_NR2	32..387	CDD:380601
		PBP2_iGluR_NMDA_Nr2	403..802	CDD:270436	94/439 (21%)
		NMDAR2_C	839..1464	CDD:463148	1/3 (33%)