Protein Alignment Ir76b and Grik2

DIOPT Version :10

• Sequence 1: NP_649176.1
• Gene: Ir76b / 40198
• FlyBaseID: FBgn0036937
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: XP_011241422.1
• Gene: Grik2 / 14806
• MGIID: 95815
• Length: 943
• Species: Mus musculus
• Alignment Length: 543
• Identity: 114/543 - (20%)
• Similarity: 199/543 - (36%)
• Gaps: 120/543 - (22%)

  Fly    41 TELPMDV-DASEAGFDADA---PVETLETINRKKPKLREMLDWIGGKHLRIATL----------E 91
            |:..:|| ...|.|.:...   |...|.....:|.|...:.|.:..:.|.:.|:          .
Mouse   385 TDFDLDVISLKEEGLEKIGTWDPSSGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKS 449

  Fly    92 DFPLSYTEVLENGTRVGHGVSFQIIDFLKKKFNFTYEVVVPQDNIIGSPSDFD-------RSLIE 149
            |.||...:..|       |....::..|.....||||:.:.:|...|:..|.:       |.||:
Mouse   450 DKPLYGNDRFE-------GYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDVNGQWNGMVRELID 507

  Fly   150 MVNSSTVDLAAAFIPSLSDQRSFVYYSTTTLDEGEWIMVM------QRPRESASG-SGLLAPFEF 207
                ...|||.|.:       :..|.....:|..:..|.:      ::|..:..| ...|.|...
Mouse   508 ----HKADLAVAPL-------AITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSP 561

  Fly   208 WVWILILVSLLAVGPIIYALIILRNRLT------------------------------------- 235
            .:|:.||::.|.|..::: :|..:::.:
Mouse   562 DIWMYILLAYLGVSCVLF-VIARQSKFSWFKYPNCSHYHHSQRCLCTQHLESYMELCLFSPYEWY 625

  Fly   236 --------GDGQQTPYSLGHCAWFVYGALMKQGSTLSPIADSTRLLFATWWIFITILTSFYTANL 292
                    .|..:..::|.:..||..||||:|||.|.|.|.|||::...||.|..|:.|.|||||
Mouse   626 NPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANL 690

  Fly   293 TAFLTLSKFTLPYNTVNDILTKNKHFVSMRGGGVEYAIRTT---NESLSMLNRMIQNNYAVFSDE 354
            .||||:.:...|.::.:|:..:.|    :..|.||.....|   ...:|..::|    :|..|..
Mouse   691 AAFLTVERMESPIDSADDLAKQTK----IEYGAVEDGATMTFFKKSKISTYDKM----WAFMSSR 747

  Fly   355 TNDTYNLQNYVEKNGYVFVRDRPAINIMLYRDYLY---RKTVSFSDEKVHCPFAMAKEPFLKKKR 416
            .      |:.:.|:      :...|..:|..||.:   ..|:.|..:: :|...........|..
Mouse   748 R------QSVLVKS------NEEGIQRVLTSDYAFLMESTTIEFVTQR-NCNLTQIGGLIDSKGY 799

  Fly   417 TFAYPIGSNLSQLFDPELLHLVESGIVKHLSKRNLPSAEICPQDLGGTERQLRNGDLMMTYYIML 481
            ....|:||.........:|.|.|.|.: |:.|........||::.......|...::...:.::.
Mouse   800 GVGTPMGSPYRDKITIAILQLQEEGKL-HMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLA 863

  Fly   482 AGFATALAVFSTELMFRYVNSRQ 504
            ||...::.|...|.:::...:.|
Mouse   864 AGLVLSVFVAVGEFLYKSKKNAQ 886

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Lig_chan-Glu_bd	83..192	CDD:463166	25/131 (19%)
		Lig_chan	209..458	CDD:459656	67/299 (22%)
Grik2	XP_011241422.1	PBP1_iGluR_Kainate	37..414	CDD:380605	7/28 (25%)
		Periplasmic_Binding_Protein_Type_2	430..835	CDD:473866	96/445 (22%)