DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir76b and Grik1

DIOPT Version :9

Sequence 1:	NP_649176.1	Gene:	Ir76b / 40198	FlyBaseID:	FBgn0036937	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	XP_006522977.1	Gene:	Grik1 / 14805	MGIID:	95814	Length:	949	Species:	Mus musculus

Alignment Length:	448	Identity:	95/448 - (21%)
Similarity:	173/448 - (38%)	Gaps:	104/448 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 IDFLKKKFN---FTYEVVVPQDNIIGSPSDFD--RSLIEMVNSSTVDLAAAFIPSLSDQRSFVYY 175
            :|.||:..|   |.|:|.:..|...|:.:|..  ..:::.:.....|||.|.:       :..|.
Mouse   480 LDLLKELSNILGFLYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPL-------TITYV 537

  Fly   176 STTTLDEGEWIMVM------QRPRESASG-SGLLAPFEFWVWILILVSLLAVGPIIYALIILRNR 233
            ....:|..:..|.:      ::|..:..| ...|.|....:|:.:|::.|.|..:::.:.    |
Mouse   538 REKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIA----R 598

  Fly   234 LT-------------GDGQQTPYSLGHCAWFVYGALMKQGSTLSPIADSTRLLFATWWIFITILT 285
            .|             .|..:..::|.:..||..||||:|||.|.|.|.|||::...||.|..|:.
Mouse   599 FTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIII 663

  Fly   286 SFYTANLTAFLTLSKFTLPYNTVNDILTKNK-HFVSMRGGGV--------------EYAIRTTNE 335
            |.|||||.||||:.:...|.::.:|:..:.| .:.::|.|..              .:|..::.:
Mouse   664 SSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQ 728

  Fly   336 SLSM-------LNRMIQNNYAVFSDETNDTYNLQ---NYVEKNGYVFVRDRPAINIMLYRDYLYR 390
            ..::       :.|::..:||:..:.|:..|..|   |..:..|.:
Mouse   729 QSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLI------------------- 774

  Fly   391 KTVSFSDEKVHCPFAMAKEPFLKKKRTFAYPIGSNLSQLFDPELLHLVESGIVKHLSKRNLPSAE 455
                  |.|.:               ....||||.........:|.|.|.|.: |:.|.......
Mouse   775 ------DSKGY---------------GVGTPIGSPYRDKITIAILQLQEEGKL-HMMKEKWWRGN 817

  Fly   456 ICPQDLGGTERQLRNGDLMMTYYIMLAGFATALAVFSTELMF--RYVNSRQEANKWAR 511
            .||::.......|...::...:.::.||...::.|...|.::  |..|..::..|.:|
Mouse   818 GCPEEDSKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSRKNNDIEQKGKSSR 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Periplasmic_Binding_Protein_Type_2	83..437	CDD:304360	79/370 (21%)
Grik1	XP_006522977.1	PBP1_iGluR_Kainate	38..431	CDD:380605
Grik1	XP_006522977.1	Periplasmic_Binding_Protein_Type_2	446..815	CDD:389745	84/386 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846423
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740