Protein Alignment Ir76b and Grid1

DIOPT Version :10

• Sequence 1: NP_649176.1
• Gene: Ir76b / 40198
• FlyBaseID: FBgn0036937
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_032192.2
• Gene: Grid1 / 14803
• MGIID: 95812
• Length: 1009
• Species: Mus musculus
• Alignment Length: 614
• Identity: 155/614 - (25%)
• Similarity: 246/614 - (40%)
• Gaps: 107/614 - (17%)

  Fly    74 REMLDWIGGKHLRIATL--EDFPLSYTEVLENGTRVGHGVSFQIIDFLKKKFNFTYEVVVPQDNI 136
            |.|...:.|..|::.|:  |.|.:....:|....|. .|.|..::|.|.|...|.||:....|..
Mouse   428 RPMGSRLQGLTLKVVTVLEEPFVMVAENILGQPKRY-KGFSIDVLDALAKALGFKYEIYQAPDGR 491

  Fly   137 IGSP---SDFDRSLIEMVNSSTVDLAAAFIPSLSDQRSFVYYSTTTLDEGEWIMVMQRPRESASG 198
            .|..   :.::..:.|:: |...|||.:.|....::.|.|.:|...:|....|:: ::|.|..|.
Mouse   492 YGHQLHNTSWNGMIGELI-SKRADLAISAITITPERESVVDFSKRYMDYSVGILI-KKPEEKISI 554

  Fly   199 SGLLAPFEFWVWILILVSLLAVGPIIYALIILRNRLTGDGQQT--------PYSLGHCAWFVYGA 255
            ..|.|||:|.||..|..::..||.:|:.|    ||:.....|:        ..:|....|.||||
Mouse   555 FSLFAPFDFAVWACIAAAIPVVGVLIFVL----NRIQAVRSQSATQPRPSASATLHSAIWIVYGA 615

  Fly   256 LMKQGSTLSPIADSTRLLFATWWIFITILTSFYTANLTAFLTLSKFTLPYNTVNDILTK-NKHFV 319
            .::||...|..:.:.|::..:||:|..|:.|.|||||.||||:|:...|..|..|:..: ...:.
Mouse   616 FVQQGGESSVNSVAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQLEMSYG 680

  Fly   320 SMRGGGV-EY-AIRTTN-----ESLSMLNRMIQNNYAVFSDETNDTYNLQNYVEKNGYVFVRDRP 377
            ::|...| || ..:.||     .:.:.|.|.|..|....:..:|.:..::. .:|..|.|:.|
Mouse   681 TVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADNCVSNPSEGIRK-AKKGNYAFLWD-- 742

  Fly   378 AINIMLYRDYLYRKTVSFSDEKVHCPFAMAKEPFLKKKRTFAYPIGSNLSQLFDPELLHLVESGI 442
             :.::.|        .:.:|:  .|...:.......|....|...||....||...:|.|.::|.
Mouse   743 -VAVVEY--------AALTDD--DCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGD 796

  Fly   443 VKHLSKRNLPSAEICPQDLGG-----TE-RQLRNGDLMMTYYIMLAGFATALAVFSTELMFRYVN 501
            :..|.::..|....|  ||..     || :.|:.......:.|:..|...|..|.:.||.:....
Mouse   797 LDVLKQKWWPHTGRC--DLTSHSSTQTEGKSLKLHSFAGVFCILAIGLLLACLVAALELWWNSNR 859

  Fly   502 SRQEANKWARHGIGRTPNGQSVAPSRWLRGWRRLNS------GHGQL-----------LGASTHG 549
            ..||..|     ..:..|.:.|        .||:||      .|.|:           :|.....
Mouse   860 CHQETPK-----EDKEVNLEQV--------HRRINSLMDEDIAHKQISPASIELSALEMGGLAPS 911

  Fly   550 QNVTPPPPYQ------SIF--NGGSHGDPLNRWRRPLANGNALGNGVLLGGDSEGGVRRLINGRD 606
            |.:.|...||      |.|  ...|||.     .|.|::|.:....:.|   |.......|..:
Mouse   912 QALEPTREYQNTQLSVSTFLPEQSSHGT-----SRTLSSGPSSNLPLPL---SSSATMPSIQCK- 967

  Fly   607 YMVFRNPNG----QSQLVPVRSPSAALFQ 631
               .|:|||    ||   ||::|....||
Mouse   968 ---HRSPNGGLFRQS---PVKTPIPMSFQ 990

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Lig_chan-Glu_bd	83..192	CDD:463166	27/113 (24%)
		Lig_chan	209..458	CDD:459656	67/264 (25%)
Grid1	NP_032192.2	Interaction with CBLN1. /evidence=ECO:0000269|PubMed:27418511	21..436		2/7 (29%)
		PBP1_iGluR_delta_1	25..425	CDD:380615
		PBP2_iGluR_delta_1	436..806	CDD:270448	102/390 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	931..960		8/36 (22%)