Protein Alignment Ir76b and Gria2

DIOPT Version :9

• Sequence 1: NP_649176.1
• Gene: Ir76b / 40198
• FlyBaseID: FBgn0036937
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_001344853.2
• Gene: Gria2 / 14800
• MGIID: 95809
• Length: 901
• Species: Mus musculus
• Alignment Length: 575
• Identity: 131/575 - (22%)
• Similarity: 216/575 - (37%)
• Gaps: 149/575 - (25%)

  Fly    27 NLIQMGENG------------TLSPVTELPMDVDASEAGFDADAPVET--LETINRKKPKLREML 77
            |::::..||            .:..:||||...|.|  |.:....|.|  ||:......|..|||
Mouse   374 NIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTS--GLENKTVVVTTILESPYVMMKKNHEML 436

  Fly    78 DWIGGKHLRIATLEDFPLSYTEVLENGTRVGHGVSFQIIDFLKKKFNFTYEVVVPQDNIIGSPSD 142
            :                         |.....|....:...:.|...|.|::.:..|...|: .|
Mouse   437 E-------------------------GNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGA-RD 475

  Fly   143 FDRSLIE-MVNS---STVDLAAAFIPSLSDQRSFVYYSTTTLDEGEWIMVMQRPRESASG-SGLL 202
            .|..:.. ||..   ...|:|.|.:.....:...:.:|...:..|..||: ::|::|..| ...|
Mouse   476 ADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMI-KKPQKSKPGVFSFL 539

  Fly   203 APFEFWVWILILVSLLAVGPIIYALIILRNRLT---------GDGQQT-------PYSLGHCAWF 251
            .|..:.:|:.|:.:.:.|..:::    |.:|.:         .||::|       .:.:.:..||
Mouse   540 DPLAYEIWMCIVFAYIGVSVVLF----LVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWF 600

  Fly   252 VYGALMKQGSTLSPIADSTRLLFATWWIFITILTSFYTANLTAFLTLSKFTLP------------ 304
            ..||.|:||..:||.:.|.|::...||.|..|:.|.|||||.||||:.:...|
Mouse   601 SLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTE 665

  Fly   305 --YNTVNDILTK-----------NKHFVSMRGGGVEYAIRTTNESLSMLNRMIQNNYAVFSDETN 356
              |.|::...||           :|.:..||.......:|||.|.::.: |..:..||...:.|
Mouse   666 IAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARV-RKSKGKYAYLLEST- 728

  Fly   357 DTYNLQNYVEKNGYVFVRDRPAINIMLYRDYLYRKTVSFSDEKVHCPFAMAKEPFLKKKRTFAYP 421
                :..|:|:        |...:.|        |.....|.|.:               ..|.|
Mouse   729 ----MNEYIEQ--------RKPCDTM--------KVGGNLDSKGY---------------GIATP 758

  Fly   422 IGSNLSQLFDPELLHLVESGIVKHL-SKRNLPSAEICPQDLGGTER--QLRNGDLMMTYYIMLAG 483
            .||:|....:..:|.|.|.|::..| :|......|...:|.|..|:  .|...::...:||::.|
Mouse   759 KGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVGG 823

  Fly   484 FATALAVFSTELMFRYVNSRQEANKW-----------ARHGI-GRT-PNGQSVAP 525
            ...|:.|...|..::   ||.||.:.           ||..| |.| .||:.:.|
Mouse   824 LGLAMLVALIEFCYK---SRAEAKRMKMTLSAATRNKARLSITGSTGENGRVMTP 875

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Periplasmic_Binding_Protein_Type_2	83..437	CDD:304360	85/399 (21%)
Gria2	NP_001344853.2	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	3/23 (13%)
		PBP2_iGluR_AMPA	413..794	CDD:270433	98/448 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846437
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840