Protein Alignment Ir76b and Gria1

DIOPT Version :10

• Sequence 1: NP_649176.1
• Gene: Ir76b / 40198
• FlyBaseID: FBgn0036937
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_032191.2
• Gene: Gria1 / 14799
• MGIID: 95808
• Length: 907
• Species: Mus musculus
• Alignment Length: 593
• Identity: 128/593 - (21%)
• Similarity: 220/593 - (37%)
• Gaps: 138/593 - (23%)

  Fly    62 TLETINRKKPKLREMLDW--------------IGGKHLRIATLEDFPLSYTEVLEN--------- 103
            ||..|..|...:|::..|              .||.:   :::::.....|.:||:
Mouse   365 TLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDN---SSVQNRTYIVTTILEDPYVMLKKNA 426

  Fly   104 ----GTRVGHGVSFQIIDFLKKKFNFTYEVVVPQDNIIGSPSDFDRSLIEMVNS---STVDLAAA 161
                |.....|...::...:.|...::|.:.:..|...|:.....::...||..   ...|:|.|
Mouse   427 NQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVA 491

  Fly   162 FIPSLSDQRSFVYYSTTTLDEGEWIMVMQRPRESASG-SGLLAPFEFWVWILILVSLLAVGPIIY 225
            .:.....:...:.:|...:..|..||: ::|::|..| ...|.|..:.:|:.|:.:.:.|..:::
Mouse   492 PLTITLVREEVIDFSKPFMSLGISIMI-KKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLF 555

  Fly   226 ALIIL-------------RNRLTGDGQQTPYSLGHCAWFVYGALMKQGSTLSPIADSTRLLFATW 277
            .:...             |::.|.| |...:.:.:..||..||.|:||..:||.:.|.|::...|
Mouse   556 LVSRFSPYEWHSEEFEEGRDQTTSD-QSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVW 619

  Fly   278 WIFITILTSFYTANLTAFLTLSKFTLPYNTVNDIL--------------TK-----------NKH 317
            |.|..|:.|.|||||.||||:.:...|..:..|:.              ||           .|.
Mouse   620 WFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKM 684

  Fly   318 FVSMRGGGVEYAIRTTNESLSMLNRMIQNNYAVFSDETNDTYNLQNYVEKNGYVFVRDRPAINIM 382
            :..|:.......:|||.|.:..: |..:..||...:.|     :..|:|:        |...:.|
Mouse   685 WTYMKSAEPSVFVRTTEEGMIRV-RKSKGKYAYLLEST-----MNEYIEQ--------RKPCDTM 735

  Fly   383 LYRDYLYRKTVSFSDEKVHCPFAMAKEPFLKKKRTFAYPIGSNLSQLFDPELLHLVESGIVKHLS 447
                    |.....|.|.:               ..|.|.||.|....:..:|.|.|.|::..|.
Mouse   736 --------KVGGNLDSKGY---------------GIATPKGSALRNPVNLAVLKLNEQGLLDKLK 777

  Fly   448 KRNLPSAEICPQDLGGTERQLRNGDLMMT-----YYIMLAGFATALAVFSTELMFRYVNSRQEAN 507
            .:.......|..  ||.:.:.:...|.::     :||::.|...|:.|...|..::   ||.|:.
Mouse   778 NKWWYDKGECGS--GGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYK---SRSESK 837

  Fly   508 KWARHGIGRTPN---GQSVAPSRWLRGWRRLNSGHGQLLGASTHGQN---VTP--PPPYQSI-FN 563
            :  ..|....|.   .:::..|...|     |||.| ..|.|..|:|   |:.  |...||| ..
Mouse   838 R--MKGFCLIPQQSINEAIRTSTLPR-----NSGAG-ASGGSGSGENGRVVSQDFPKSMQSIPCM 894

  Fly   564 GGSHGDPL 571
            ..|.|.||
Mouse   895 SHSSGMPL 902

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Lig_chan-Glu_bd	83..192	CDD:463166	18/124 (15%)
		Lig_chan	209..458	CDD:459656	63/286 (22%)
Gria1	NP_032191.2	PBP1_iGluR_AMPA_GluR1	26..392	CDD:380613	6/26 (23%)
		PBP2_iGluR_AMPA_GluR1	406..787	CDD:270447	86/419 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	857..881		10/29 (34%)
		PDZ-binding	904..907