DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir76b and GRIN3B

DIOPT Version :9

Sequence 1:	NP_649176.1	Gene:	Ir76b / 40198	FlyBaseID:	FBgn0036937	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_619635.1	Gene:	GRIN3B / 116444	HGNCID:	16768	Length:	1043	Species:	Homo sapiens

Alignment Length:	442	Identity:	91/442 - (20%)
Similarity:	150/442 - (33%)	Gaps:	144/442 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 LRIATLEDFPLSYTE------------------------------VLENGT------RVGHGVSF 113
            ||:.||.:.|..:..                              .|.||:      :..:|...
Human   417 LRVVTLLEHPFVFARDPDEDGQCPAGQLCLDPGTNDSATLDALFAALANGSAPRALRKCCYGYCI 481

  Fly   114 QIIDFLKKKFNFTYEVVVPQDNIIGSPSDFD-RSLIEMVNSSTVDLAAAFIPSLSDQRSFV---- 173
            .:::.|.:...|.:|:.:..|...|:..|.. ..|:..:.:....:|.... |::..||.|
Human   482 DLLERLAEDTPFDFELYLVGDGKYGALRDGRWTGLVGDLLAGRAHMAVTSF-SINSARSQVVDFT 545

  Fly   174 --YYSTTTLDEGEWIMVMQRPRESASGSG-LLAPFEFWVWILILVSLLAVGPIIYALII------ 229
              ::||:       :.:|.|.|::||..| .:.|..:..|:.:..:|     .:.||.:
Human   546 SPFFSTS-------LGIMVRARDTASPIGAFMWPLHWSTWLGVFAAL-----HLTALFLTVYEWR 598

  Fly   230 ----LRNRLTGDGQQTPYSLGHCAWFVYGALMKQG-STLSPIADSTRLLFATWWIFITILTSFYT 289
                |..|  |..:.|.:|........|..|.::. |:.:|...:.|||...|.||..::.|.||
Human   599 SPYGLTPR--GRNRSTVFSYSSALNLCYAILFRRTVSSKTPKCPTGRLLMNLWAIFCLLVLSSYT 661

  Fly   290 ANLTA-------FLTLSKFTLP----------YNTVNDILTK---NKHFVSMRGGGVEYAIRTTN 334
            |||.|       |..||....|          :.||.:...:   .|.|..|......::..||.
Human   662 ANLAAVMVGDKTFEELSGIHDPKLHHPAQGFRFGTVWESSAEAYIKKSFPDMHAHMRRHSAPTTP 726

  Fly   335 ESLSMLNRMIQNNYAVFSDETNDTYNLQNYVEKNGYVFVRDRPAINIMLYRDYLYRKTVSFSDEK 399
            ..::||              |:|...|.        .|:.|:..:      ||    .||...:
Human   727 RGVAML--------------TSDPPKLN--------AFIMDKSLL------DY----EVSIDAD- 758

  Fly   400 VHCPFAMAKEPFLKKKRTFAYPIG--------SNLSQLFDP-------ELLH 436
              |......:||..:    .|.||        ||||:....       :|||
Human   759 --CKLLTVGKPFAIE----GYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLH 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Periplasmic_Binding_Protein_Type_2	83..437	CDD:304360	91/442 (21%)
GRIN3B	NP_619635.1	PBP1_iGluR_NMDA_NR3	19..405	CDD:107372
		PBP2_iGluR_NMDA_Nr3	415..808	CDD:270438	91/442 (21%)
		Lig_chan	576..842	CDD:278489	61/275 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156001
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740