DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir76b and GRIN3A

DIOPT Version :9

Sequence 1:	NP_649176.1	Gene:	Ir76b / 40198	FlyBaseID:	FBgn0036937	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_597702.2	Gene:	GRIN3A / 116443	HGNCID:	16767	Length:	1115	Species:	Homo sapiens

Alignment Length:	654	Identity:	126/654 - (19%)
Similarity:	214/654 - (32%)	Gaps:	210/654 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 KPKLREMLDWIGGK-------------------------HLRIATLEDFPLSYT-EVLENG---- 104
            ||....:..|.|||                         |||:.||.:.|..:| ||.:.|
Human   475 KPMWTRLGSWQGGKIVMDYGIWPEQAQRHKTHFQHPSKLHLRVVTLIEHPFVFTREVDDEGLCPA 539

  Fly   105 ---------------------------------TRVGHGVSFQIIDFLKKKFNFTYEVVVPQDNI 136
                                             .:..:|....:::.:.:..||.:::.:..|..
Human   540 GQLCLDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEKIAEDMNFDFDLYIVGDGK 604

  Fly   137 IGS---------PSDFDRSLIEM-VNSSTVDLAAAFIPSLSDQRSFVYYSTTTLDEGEWIMVMQR 191
            .|:         ..|..|....| |.|.:::.|.:.:...:..    ::||:       :.::.|
Human   605 YGAWKNGHWTGLVGDLLRGTAHMAVTSFSINTARSQVIDFTSP----FFSTS-------LGILVR 658

  Fly   192 PRESASGSG-LLAPFEFWVWILILVSLLAVGPIIYALIILRN--RLT--GDGQQTPYSLGHCAWF 251
            .|::|:..| .:.|..:.:|:.|.|: |.:..:...|...::  .||  |..:...:|.......
Human   659 TRDTAAPIGAFMWPLHWTMWLGIFVA-LHITAVFLTLYEWKSPFGLTPKGRNRSKVFSFSSALNI 722

  Fly   252 VYGALMKQGSTLS---PIADSTRLLFATWWIFITILTSFYTANLTAFLTLSKFTLPYNTVNDILT 313
            .|..|.  |.|::   |...:.|.|...|.||.....|.|||||.|.:...|.   |..::.|..
Human   723 CYALLF--GRTVAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKI---YEELSGIHD 782

  Fly   314 KNKH-------FVSMRGGGVEYAIRTTNESLSMLNRMIQNNYAVFSDETNDTYNLQNYVEKNGYV 371
            ...|       |.::|....|..:|   :|...::..:: .|.|.:......| |:|..||.. .
Human   783 PKLHHPSQGFRFGTVRESSAEDYVR---QSFPEMHEYMR-RYNVPATPDGVEY-LKNDPEKLD-A 841

  Fly   372 FVRDRPAINIMLYRDYLYRKTVSFSDEKVHCPFAMAKEPFLKKKRTFAYPIG--------SNLSQ 428
            |:.|:..:      ||    .||...:   |......:||..:    .|.||        :|:|:
Human   842 FIMDKALL------DY----EVSIDAD---CKLLTVGKPFAIE----GYGIGLPPNSPLTANISE 889

  Fly   429 LFDP-------ELLH-----LVESGIVKHLSKRNLPSAEICPQDLGGTERQLRNGDLMMTYYIML 481
            |...       ::||     :|..|      ||:....|..         |:........:.::.
Human   890 LISQYKSHGFMDMLHDKWYRVVPCG------KRSFAVTETL---------QMGIKHFSGLFVLLC 939

  Fly   482 AGFATALA-------------------------VFSTELMFRYVNSRQEANKWARHGIGRTPNGQ 521
            .||..::.                         :.:::.:.|.:|:.....|.......|.....
Human   940 IGFGLSILTTIGEHIVYRLLLPRIKNKSKLQYWLHTSQRLHRAINTSFIEEKQQHFKTKRVEKRS 1004

  Fly   522 SVAPSRWLRGWRRLNSGH------------GQ-LLGASTHGQNVTPPP-----PYQSIFNGGSHG 568
            :|.| |.|..|...|..|            || .||...| |::..||     |.....||  ..
Human  1005 NVGP-RQLTVWNTSNLSHDNRRKYIFSDEEGQNQLGIRIH-QDIPLPPRRRELPALRTTNG--KA 1065

  Fly   569 DPLN 572
            |.||
Human  1066 DSLN 1069

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Periplasmic_Binding_Protein_Type_2	83..437	CDD:304360	88/461 (19%)
GRIN3A	NP_597702.2	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	6/21 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	59..118
		ANF_receptor	127..469	CDD:279440
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	87/435 (20%)
		Lig_chan	676..942	CDD:278489	65/309 (21%)
		PPP2CB binding site. /evidence=ECO:0000250	951..987		2/35 (6%)
		GIT1-binding. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	1062..1095		5/10 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155991
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740