Protein Alignment Ir76b and grin2a

DIOPT Version :10

• Sequence 1: NP_649176.1
• Gene: Ir76b / 40198
• FlyBaseID: FBgn0036937
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: XP_031749422.1
• Gene: grin2a / 100489006
• XenbaseID: XB-GENE-992741
• Length: 1450
• Species: Xenopus tropicalis
• Alignment Length: 595
• Identity: 130/595 - (21%)
• Similarity: 215/595 - (36%)
• Gaps: 168/595 - (28%)

  Fly    10 AAALCVACPPLNDSPPTNLIQMGENGTLSPVTELPMDVDASEAGFDADAPVETL----------- 63
            |...|.|....|:.|...|.:...|     ||....|:..:|.|:.|:..:..|
 Frog   308 AKTSCYAQNERNEPPLHTLHKFMIN-----VTWDGKDLSFTEDGYQANPKLVVLLLNMDREWEKV 367

  Fly    64 -----ETINRKK---PKLREMLDW-IGGKHLRIATLEDFPLSYTE-------------------- 99
                 :::|.|.   |::...||. ....||.|.|||:.|....|
 Frog   368 GKWENKSLNMKYPVWPRITASLDSDPDDNHLSIVTLEEAPFVIVENVDYLTGTCVRNTVPCRKYF 432

  Fly   100 VLENGTRVG-------HGVSFQIIDFLKKKFNFTYEVVVPQDNIIGS--PSDFDRSLIEMVNSST 155
            .|.|.|..|       .|....|:..|.|...|||::.:..:...|.  .:.::..:.|:|....
 Frog   433 RLNNSTTEGTSVKKCCKGFCIDILKKLSKTVKFTYDLYLVTNGKHGKKIKNVWNGMIGEVVYKRA 497

  Fly   156 VDLAAAFIPSLSDQRS-FVYYSTTTLDEGEWIMVMQRPRESASGSGLLAPFEFWVWILILVSLLA 219
            |....:.  :::::|| .|.:|...::.|..:|| .|...:.|.|..|.||...||:::.|.||.
 Frog   498 VMAVGSL--TINEERSEAVDFSVPFVETGISVMV-SRSNGTVSPSAFLEPFSASVWVMMFVMLLL 559

  Fly   220 VGPIIYALIILR-------NRLTGDGQQ---TPYSLGHCAWFVYGALMKQGSTL-SPIADSTRLL 273
            |..:  |:.:..       ||...||:.   ..:::|...|.::|.:......: :|...:::::
 Frog   560 VSAV--AVFVFEYFSPVGYNRNLADGKAPHGPSFTIGKAVWLLWGLVFNNSVPVQNPKGTTSKII 622

  Fly   274 FATWWIFITILTSFYTANLTAFLTLSKFTLPYNTVNDILTKNKH-------FVSMRGGGVEYAIR 331
            .:.|..|..|..:.|||||.||:...:|......::|...:..|       |.::..|..|
 Frog   623 VSIWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTE---- 683

  Fly   332 TTNESLSMLNRMIQNNYAVFSDETNDTYNLQNYVEK---NGY-------------VFVRDRPAIN 380
                      |.|:|||.          ::..|:.|   .|.             .|:.|...:|
 Frog   684 ----------RNIRNNYP----------DMHQYMVKFHQKGVQDALVSLKTGKLDAFIYDAAVLN 728

  Fly   381 IMLYRD-----------YLYRKTVSFSDEKVHCPFAMAKEPFLKKKRTFAYPIGSNLSQLFDPEL 434
            .|..||           |::..|          .:.:|    |:|        ||...:..|..|
 Frog   729 YMAGRDEGCKLVTIGSGYIFATT----------GYGIA----LQK--------GSRWKRPIDLAL 771

  Fly   435 LHLVESGIVKHLSKRNLPSAEICPQDLGGTER------QLRNGDLMMTYYIMLAGFATALAVFST 493
            |..|..|.::.|.|..|..  ||     .||:      ||...::...:|::.|..|.:|..|..
 Frog   772 LQFVGDGEMEELEKLWLTG--IC-----HTEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFVW 829

  Fly   494 ELMF----RY 499
            |.:|    ||
 Frog   830 EHLFYWKLRY 839

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Lig_chan-Glu_bd	83..192	CDD:463166	30/138 (22%)
		Lig_chan	209..458	CDD:459656	61/293 (21%)
grin2a	XP_031749422.1	PBP1_iGluR_NMDA_NR2	26..379	CDD:380601	15/75 (20%)
		PBP2_iGluR_NMDA_Nr2	395..793	CDD:270436	98/455 (22%)
		NMDAR2_C	831..1450	CDD:463148	3/9 (33%)