DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir76b and grin3bb

DIOPT Version :9

Sequence 1:	NP_649176.1	Gene:	Ir76b / 40198	FlyBaseID:	FBgn0036937	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	XP_017213803.2	Gene:	grin3bb / 100333101	ZFINID:	ZDB-GENE-131122-77	Length:	1114	Species:	Danio rerio

Alignment Length:	689	Identity:	126/689 - (18%)
Similarity:	216/689 - (31%)	Gaps:	224/689 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 REMLDW-----IGGKHLRIATLEDFPLSYT-EVLENG---------------------------- 104
            ||...|     :.|..||:.||.:.|..:| ||.|:|
Zfish   442 REGRRWRAGFPVSGSRLRVVTLVEHPFVFTREVDEDGNCPAGQYCLDAGTNSSETLDHLYAERAQ 506

  Fly   105 ----------TRVGHGVSFQIIDFLKKKFNFTYEVVVPQDNIIGSPSDFD-RSLIEMVNSSTVDL 158
                      ::..:|....:::.|.:..||.:::.:..|...|:..... ..|:..:.|...|:
Zfish   507 GNKSFLPPDYSKCCYGYCIDLLEKLSEDMNFEFDLYIVGDGKYGAVKGGQWTGLVGDLLSGVADM 571

  Fly   159 AAAFIPSLSDQRSFV------YYSTTTLDEGEWIMVMQRPRESASGSG-LLAPFEFWVWILILVS 216
            |.... |::..||.|      ::||:       :.::.|.:::|:..| .:.|..:.:|:.|.|:
Zfish   572 AVTSF-SINSARSKVIDFTSPFFSTS-------LGILVRSKDTAAPIGAFMWPLHWSMWMGIFVA 628

  Fly   217 LLAVGPIIYALIILRNRLTGDGQQTPYSLGHCAWFVYGALMKQ------GSTLS---PIADSTRL 272
            |     .|.||.:...........||:.......|.|.:.:..      |.|:|   |...:.|.
Zfish   629 L-----HITALFLTLYEWKSPFGMTPHGRNRVKVFSYSSALNLCYAILFGRTVSSKTPKCWTGRF 688

  Fly   273 LFATWWIFITILTSFYTANLTAFLTLSKFTLPYNTVNDILTKNKHFVSMRGGGVEYAIRTTNESL 337
            |...|.||..::.|.|||||.|.:...|   .:..|:.|.....|..|.   |..:.  |..||
Zfish   689 LMNLWAIFCLLVLSSYTANLAAVMVGEK---TFEEVSGIHDAKLHHPSQ---GFRFG--TVRES- 744

  Fly   338 SMLNRMIQNNYAVFSDETNDTYNLQNYVEKNGYV--------------FVRDRPAINIMLYRDYL 388
                             :.:.|..:::.|.:.|:              ...|.|.::..:....|
Zfish   745 -----------------SAEDYMKKSFPEMHEYMRKFNEPTTPDGVATLKTDPPQLDAFIMDKAL 792

  Fly   389 YRKTVSFSDEKVHCPFAMAKEPFLKKKRTFAYPIG--------SNLSQLFD-------PELLHLV 438
            ....||...:   |......:||..:    .|.||        ||:|:...       .::||..
Zfish   793 LDYEVSIDAD---CKLLTVGKPFAIE----GYGIGLPQNSPLTSNISEFVSRYKSDGYMDMLHDK 850

  Fly   439 ESGIVKHLSKRNLPSAEICPQDLGGTERQLRNG--DLMMTYYIMLAGFATALAVFSTE-----LM 496
            ...:|.            |.:.:......|:.|  .....:.::..|...||...:.|     |:
Zfish   851 WYKVVP------------CGKRVFAVTETLQMGIRHFSGLFVLLCVGVTGALLTLAGEHAFYRLV 903

  Fly   497 FRYVNSRQEANKWARHGIGRTPNGQSVAPSRWLRGWRRLNSGHGQL------LGASTHGQNVTPP 555
            ..::..:|:...|..       ..|.:        .|.||..:..:      ...|.:.|...|.
Zfish   904 LPHIRRKQKFKYWLH-------TSQKI--------HRALNMTYEDVKRQRANTEKSCNIQKAQPH 953

  Fly   556 PPYQSIFNGGSHGDPLN---RWRRPLA-------------------NGNALGNGVLLGGDSEGGV 598
            ||.|..        ||.   ||....|                   |...|...|:..|......
Zfish   954 PPPQPA--------PLGSFARWNNESAKVAQEPKDNKRVHFNLETLNTRRLLPRVVSDGGQTSSA 1010

  Fly   599 RRLINGRDYMVFR------------------NPNGQSQL 619
            ..|.:|...::.|                  :|:||.:|
Zfish  1011 STLSSGAGSLLARVCENGGPVQRATSSVRSSSPSGQDEL 1049

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Periplasmic_Binding_Protein_Type_2	83..437	CDD:304360	84/438 (19%)
grin3bb	XP_017213803.2	PBP1_iGluR_NMDA_NR3	29..428	CDD:107372
grin3bb	XP_017213803.2	PBP2_iGluR_NMDA_Nr3	457..852	CDD:270438	85/440 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591377
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840