DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir76b and LOC100149482

DIOPT Version :9

Sequence 1:	NP_649176.1	Gene:	Ir76b / 40198	FlyBaseID:	FBgn0036937	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	XP_009290417.1	Gene:	LOC100149482 / 100149482	-ID:	-	Length:	1959	Species:	Danio rerio

Alignment Length:	651	Identity:	134/651 - (20%)
Similarity:	234/651 - (35%)	Gaps:	203/651 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 KHLRIATLEDFPLSYTEVLE-----------------NGTRVGHGVS----------FQIIDFLK 120
            :|||:.|||:.|....|:.:                 |.:.:..||:          ..|:..|.
Zfish   433 QHLRVVTLEERPFVIVELADAASGTCIRDSVPCRRPLNASALQEGVAPVKQCCKGFCIDILKRLA 497

  Fly   121 KKFNFTYEVVVPQDNIIGSPSD-FDRSLIEMVNSSTVDLAAAFIPSLSDQRS-FVYYSTTTLDEG 183
            :...|||::.:..:...|...| ....::..|.....|:|...: :::::|| .|.:|...::.|
Zfish   498 RIVGFTYDLYLVTNGKHGKKIDGVWNGMVGEVVYKRADMAIGSL-TINEERSEVVDFSVPFVETG 561

  Fly   184 EWIMVMQRPRESASGSGLLAPFEFWVWILILVSLLAV-----------GPIIYALIILRNRLTGD 237
            ..:|| .|...:.|.|..|.|:...||:::.|..|.|           .|:.|      ||....
Zfish   562 ISVMV-SRSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEFFSPVGY------NRSLQS 619

  Fly   238 GQQ---TPYSLGHCAWFVYGALMKQGSTL-SPIADSTRLLFATWWIFITILTSFYTANLTAFLTL 298
            |::   :.:::|...|.::..:......: :|...:::::...|..|..|..:.|||||.||:..
Zfish   620 GKKAGGSKFTIGKSIWLLWALVFNNSVPVENPKGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQ 684

  Fly   299 SKFTLPYNTVNDILTKN-KH---------FVSMRGGGVEYAIRTTNESLSMLNRMIQNNYAVFSD 353
            .::   .:||:.:..|. :|         |.::..|..|..||:        |....:.|.|
Zfish   685 EEY---IDTVSGLSDKKFQHPTEQYPPLKFGTVPNGSTEKNIRS--------NYPDMHQYMV--- 735

  Fly   354 ETNDTYNLQNYVE------KNGYV--FVRDRPAINIMLYRDYLYRKTVSFSDEKVHCP--FAMAK 408
                .|| |..||      |.|.:  |:.|...:|.|..:|. ..|.::....||...  :.:|
Zfish   736 ----KYN-QKSVEDAISHLKTGKLDAFIYDAAVLNYMARKDE-GCKVMTIGSGKVFATTGYGIA- 793

  Fly   409 EPFLKKKRTFAYPIGSNLSQLFDPELLHLVE----SGIVKHLSKRNLPSAEICPQDLGGTERQLR 469
               |.|...:..|:...|.||...:.:.::|    |||. |..|..:.|:::...::.|
Zfish   794 ---LIKNSRWKRPLDLALLQLVGDDEIEMLERLWLSGIC-HNDKIEVMSSKLDIDNMAG------ 848

  Fly   470 NGDLMMTYYIMLAGFATALAVFSTE-LMFRYVNSRQEANKW-ARHGIGRTPNGQS------VAPS 526
                  .:|::|.....:|.||:.| |::           | .||.:.:.  |||      :|.|
Zfish   849 ------VFYMLLVAMGLSLLVFAWEHLVY-----------WRLRHCMSKM--GQSGKLDFLLAFS 894

  Fly   527 RWL-----------RGWRRLN-SGHGQLLGASTHGQNVT------------------------PP 555
            |.:           :|..::. |||.......|...:|.                        ||
Zfish   895 RGMYSCCSFEDETAQGGAKVTVSGHHHTAMVPTSSSHVVTSAVSNPAIAMVQQQQQQQPQQPQPP 959

  Fly   556 PPYQS--------IFNGGSHGDPLN-------------------------RWRRPLANGNALGNG 587
            ..|::        |.:.|:...|.|                         |||.|...|.....|
Zfish   960 QSYKTPLPGSPPPIVHSGAALGPANTQLIGAPLPCTTFLPRPDRRLAVVDRWRLPKTAGATTSMG 1024

  Fly   588 V 588
            |
Zfish  1025 V 1025

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Periplasmic_Binding_Protein_Type_2	83..437	CDD:304360	90/417 (22%)
LOC100149482	XP_009290417.1	PBP1_iGluR_NMDA_NR2	44..421	CDD:107373
		PBP2_iGluR_NMDA_Nr2	433..831	CDD:270436	94/430 (22%)
		HisJ	<487..>570	CDD:223904	18/84 (21%)
		Lig_chan	585..857	CDD:278489	67/314 (21%)
		NMDAR2_C	868..>900	CDD:287527	10/44 (23%)
		FAM76	<1763..>1856	CDD:292665
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591366
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.830