DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir76b and gria3

DIOPT Version :9

Sequence 1:	NP_649176.1	Gene:	Ir76b / 40198	FlyBaseID:	FBgn0036937	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_001106494.1	Gene:	gria3 / 100127683	XenbaseID:	XB-GENE-1010483	Length:	887	Species:	Xenopus tropicalis

Alignment Length:	535	Identity:	115/535 - (21%)
Similarity:	200/535 - (37%)	Gaps:	102/535 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 PLNDSPPTNLIQMGENGTLSPVTELPMDVDASEAGFDADAPVETLETINRKKPKLREMLDWIGGK 83
            |..|..|||.....||.|:...|                    .||.....|.|..|:||
Frog   401 PAPDQQPTNESSSVENKTIIVTT--------------------ILENPYVMKKKNHELLD----- 440

  Fly    84 HLRIATLEDFPLSYTEVLENGTRVGHGVSFQIIDFLKKKFNFTYEVVVPQDNIIGSPSDFDRSLI 148
                                |.....|....:...:.|.....|::.:.:|...|:.....:...
Frog   441 --------------------GNDKYEGYCVDLASEIAKHVGIKYKLSIVEDGKYGARDPETKIWN 485

  Fly   149 EMVNS---STVDLAAAFIPSLSDQRSFVYYSTTTLDEGEWIMVMQRPRESASG-SGLLAPFEFWV 209
            .||..   ...|:|.|.:.....:...:.:|...:..|..||: ::|::|..| ...|.|..:.:
Frog   486 GMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMI-KKPQKSKPGVFSFLDPLAYEI 549

  Fly   210 WILILVSLLAVGPIIYALIILRNRLT------------GDGQQTP-----YSLGHCAWFVYGALM 257
            |:.|:.:.:.|..:::    |.:|.:            .|.|..|     :.:.:..||..||.|
Frog   550 WMCIVFAYIGVSVVLF----LVSRFSPYEWHLEDTDEARDPQNPPDPPNEFGIFNSLWFSLGAFM 610

  Fly   258 KQGSTLSPIADSTRLLFATWWIFITILTSFYTANLTAFLTLSKFTLPYNTVNDILTKNK-HFVSM 321
            :||..:||.:.|.|::...||.|..|:.|.|||||.||||:.:...|..:..|:..:.: .:.::
Frog   611 QQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTL 675

  Fly   322 RGGGVEYAIRTTNESL--SMLNRMIQNNYAVFSDETNDTYNLQNYVEKNGYVFVRDRPAINIMLY 384
            ..|..:...|.:..::  .|.:.|.....:||:..|:|..   ..|.|:...|.
Frog   676 DSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTDDGV---ARVRKSKGKFA----------- 726

  Fly   385 RDYLYRKTVS-FSDEKVHCPFAMAKEPFLKKKRTFAYPIGSNLSQLFDPELLHLVESGIVKHL-S 447
              :|...|:: :.:::..|...........|....|.|.||.|....:..:|.|.|.||:..| :
Frog   727 --FLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGTPVNLAVLKLSEQGILDKLKN 789

  Fly   448 KRNLPSAEICPQDLGGTER--QLRNGDLMMTYYIMLAGFATALAVFSTELMFRYVNSRQEANKWA 510
            |......|...:|.|..::  .|...::...:||::.|...|:.|...|..::   ||.|:.:
Frog   790 KWWYDKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCYK---SRAESKR-- 849

  Fly   511 RHGIGRTPNGQSVAP 525
               :..|.|.|:..|
Frog   850 ---MKLTKNAQNFKP 861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Periplasmic_Binding_Protein_Type_2	83..437	CDD:304360	76/378 (20%)
gria3	NP_001106494.1	Periplasmic_Binding_Protein_Type_1	29..400	CDD:324556
gria3	NP_001106494.1	PBP2_iGluR_AMPA	416..798	CDD:270433	92/447 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.100