Protein Alignment Ir76b and gria4

DIOPT Version :10

• Sequence 1: NP_649176.1
• Gene: Ir76b / 40198
• FlyBaseID: FBgn0036937
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: XP_031751480.1
• Gene: gria4 / 100125052
• XenbaseID: XB-GENE-5838893
• Length: 902
• Species: Xenopus tropicalis
• Alignment Length: 572
• Identity: 114/572 - (19%)
• Similarity: 211/572 - (36%)
• Gaps: 141/572 - (24%)

  Fly    62 TLETINRKKPKLREMLDW---------------------IGGKHLRIATLEDFP-LSYT---EVL 101
            |::.:..|...||::..|                     |..:.:.:.|:.:.| :.|.   |:|
 Frog   373 TMDVLELKSNGLRKIGYWNDMDKLVLLQHEPAFKNDSSGIENRTVIVTTILEAPYVMYKKNHELL 437

  Fly   102 ENGTRVGHGVSFQIIDFLKKKFNFTYEVVVPQDNIIGSPSDFDRSLIEMVNS---STVDLAAAFI 163
            |...:. .|....:...:.|.....|::.:..|...|:.....:....||..   ...::|.|.:
 Frog   438 EGNDKF-EGYCVDLAYEIAKHIGIKYKIAIVPDGKYGARDSETKIWNGMVGELVYGKAEIAVAPL 501

  Fly   164 PSLSDQRSFVYYSTTTLDEGEWIMVMQRPRESASG-SGLLAPFEFWVWILILVSLLAVGPIIYAL 227
            .....:...:.:|...:..|..||: ::|::|..| ...|.|..:.:|:.|:.:.:.|..:::
 Frog   502 TITLVREEVIDFSKPFMSLGISIMI-KKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLF-- 563

  Fly   228 IILRNRLT---------GDGQQTP-------YSLGHCAWFVYGALMKQGSTLSPIADSTRLLFAT 276
              |.:|.:         .||::.|       :.:.:..||..||.|:||..:||.:.|.|::...
 Frog   564 --LVSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGV 626

  Fly   277 WWIFITILTSFYTANLTAFLTLSKFTLPYNTVNDIL--------------TK-----------NK 316
            ||.|..|:.|.|||||.||||:.:...|..:..|:.              ||           .|
 Frog   627 WWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDAGSTKEFFKRSKIAVYEK 691

  Fly   317 HFVSMRGGGVEYAIRTTNESLSMLNRMIQNNYAVFSDETNDTYNLQNYVEKNGYVFVRDRPAINI 381
            .:..|:........:||.|.::.: |..:..:|...:.|     :..|:|:        |...:.
 Frog   692 MWTYMKSAEPSVFTKTTAEGVARV-RKSKGKFAFLLEST-----MNEYIEQ--------RKPCDT 742

  Fly   382 MLYRDYLYRKTVSFSDEKVHCPFAMAKEPFLKKKRTFAYPIGSNLSQLFDPELLHLVESGIVKHL 446
            |        |.....|.|.:               ..|.|..|.|....:..:|.|.|.|::..|
 Frog   743 M--------KVGGNLDSKGY---------------GVATPKHSQLRNAVNLAVLKLNEQGLLDKL 784

  Fly   447 SKRNLPSAEICPQDLGGTERQLRNGDLMMT-----YYIMLAGFATALAVFSTELMFRYVNSRQEA 506
            ..:.......|..  ||.:.:.:...|.::     :||::.|...|:.|...|..::   ||.||
 Frog   785 KNKWWYDKGECGS--GGGDSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYK---SRAEA 844

  Fly   507 NKWARHGIGRTPNGQSVAPSRWLRGWRRLNSGHGQLLGA-STHGQNVTPPPP 557
            .:            ..:..|..:|...||:     :.|: ..:|:.:||..|
 Frog   845 KR------------MKLTFSEAIRNKARLS-----ITGSIGENGRVLTPDCP 879

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Lig_chan-Glu_bd	83..192	CDD:463166	19/115 (17%)
		Lig_chan	209..458	CDD:459656	61/289 (21%)
gria4	XP_031751480.1	PBP1_iGluR_AMPA_GluR4	28..400	CDD:380611	5/26 (19%)
		PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	85/423 (20%)