Protein Alignment Ir76b and grin2ca

DIOPT Version :10

• Sequence 1: NP_649176.1
• Gene: Ir76b / 40198
• FlyBaseID: FBgn0036937
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_001352716.1
• Gene: grin2ca / 100003342
• ZFINID: ZDB-GENE-070822-3
• Length: 1400
• Species: Danio rerio
• Alignment Length: 572
• Identity: 118/572 - (20%)
• Similarity: 219/572 - (38%)
• Gaps: 130/572 - (22%)

  Fly    29 IQMGENGTLSPVTELPMDVDASEAGFDADA----PVETLETINRKK------------------- 70
            |:...||||.. ..|.:..:.::..|::|.    |...:.|::|.:
Zfish   332 IRPASNGTLYR-HMLNVSWENTDFSFNSDGYLVNPSMIIITLDRGRQWDKVGNYESGILQMRYPV 395

  Fly    71 -PKLREMLDWIG-GKHLRIATLEDFPLSYTEVLE-------------------NGTRVGH----- 109
             |:....|:.:. .:||.:||||:.|....|.::                   ..|.|||
Zfish   396 WPRYGTFLEPVSDNRHLTVATLEERPFVIVEAVDPVTGTCLSNTVPCRRQSNKTETIVGHTEPYT 460

  Fly   110 -----GVSFQIIDFLKKKFNFTYEVVVPQDNIIGSPSDFDR----SLIEMVNSSTVDLAAAFIPS 165
                 |....|:..|.:...|:|::.:..:   |......|    .:|..|.....|:|...: :
Zfish   461 KLCCKGFCIDILKKLSRNIKFSYDLYLVTN---GKHGKLVRGIWNGMIGEVFYKRADMAIGSL-T 521

  Fly   166 LSDQRS-FVYYSTTTLDEGEWIMVMQRPRESASGSGLLAPFEFWVWILILVSLLAV--------- 220
            ::::|| .:.:|...::.|..:|| .|...:.|.|..|.|:...||:::.|..|.|
Zfish   522 INEERSEIIDFSVPFVETGISVMV-ARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFVFE 585

  Fly   221 --GPIIYALIILRNRLTGDGQQTPYSLGHCAWFVYGALMKQGSTL-SPIADSTRLLFATWWIFIT 282
              .|:.|...::..:   |.....:::|...|.::|.:......: :|...:::::...|..|..
Zfish   586 YCSPVGYNRSLVSAK---DPGGPTFTIGKSVWLLWGIVFNNSVPIENPKGTTSKIMVLVWAFFAV 647

  Fly   283 ILTSFYTANLTAFLTLSKFTLPYNTVNDILTKN----------KHFVSMRGGGVEYAIRTTNESL 337
            |..:.|||||.||:...::   .:||:.:..|.          ..|.::..|..|..||:...
Zfish   648 IFLASYTANLAAFMIQEQY---IDTVSGLSDKKFQKPQDQYPPFRFGTVPNGSTERNIRSNYP-- 707

  Fly   338 SMLNRMIQNNYAVFSDETNDTYNLQNYVEKNGYV--FVRDRPAINIMLYRDYLYRKTVSFSDEKV 400
            .|.:.|::.|.....|..|..        |.|.:  |:.|...:|.|..:|. ..|.|:....||
Zfish   708 EMHSHMVKYNQKGVEDALNSL--------KTGKLDAFIYDAAVLNYMAGKDE-GCKLVTIGSGKV 763

  Fly   401 HCP--FAMAKEPFLKKKRTFAYPIGSNLSQLF---DPELLHLV-ESGIVKHLSKRNLPSAEICPQ 459
            ...  :.:|    |:|:..:..||...|.|..   |.:.|..| .:||.:: .|:.:.|:::...
Zfish   764 FATTGYGIA----LQKESRWKRPIDLALLQFLADGDTQKLQTVWLTGICRN-EKKEVMSSKLDID 823

  Fly   460 DLGGTERQLRNGDLMMTYYIMLAGFATALAVFSTELMFRYVNSRQEANKWAR 511
            ::.|            .:|::|.....:|.||:.|.:. |...|....|..|
Zfish   824 NMAG------------VFYMLLVAMGLSLLVFAWEHLL-YWKLRHSVRKSER 862

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir76b	NP_649176.1	Lig_chan-Glu_bd	83..192	CDD:463166	29/142 (20%)
		Lig_chan	209..458	CDD:459656	60/278 (22%)
grin2ca	NP_001352716.1	PBP1_iGluR_NMDA_NR2	38..393	CDD:380601	11/61 (18%)
		PBP2_iGluR_NMDA_Nr2	409..810	CDD:270436	92/426 (22%)
		NMDAR2_C	847..>938	CDD:463148	4/17 (24%)