DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14185 and LRRC46

DIOPT Version :9

Sequence 1:	NP_649175.1	Gene:	CG14185 / 40197	FlyBaseID:	FBgn0036936	Length:	402	Species:	Drosophila melanogaster
Sequence 2:	XP_005257832.1	Gene:	LRRC46 / 90506	HGNCID:	25047	Length:	330	Species:	Homo sapiens

Alignment Length:	334	Identity:	81/334 - (24%)
Similarity:	117/334 - (35%)	Gaps:	110/334 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 TLDELLRRVTQRTDLEAVEQVRLRVISYTVSLSRLSLFLPRLQSLDLSGSVLSSLRDLGYGLLQL 169
            |||||   .|.|.|.|.:..:|        :|..|.    .|.||.|.|:.:..:.:|.
Human    51 TLDEL---QTVRLDREGITTIR--------NLEGLQ----NLHSLYLQGNKIQQIENLA------ 94

  Fly   170 TRLDISNCGLNSFDGTSGLPAIRVLIADGNMIQRVDPLAELVHLRVLKARNNRISELGLLSFLGM 234
                   |          :|::|.|...||.|::|:.|.:|..|:.|....|.|..|.|..|
Human    95 -------C----------IPSLRFLSLAGNQIRQVENLLDLPCLQFLDLSENLIETLKLDEF--- 139

  Fly   235 CPQ-LQEVELQGNPVCRLPLYRSLLARSVPTLQLLDGRVLNGEPAPVE--MEEATSPASSDLE-- 294
             || |..:.|.||.......||.|:..::|.  |||   |:|:|. ||  :.:....||||.|
Human   140 -PQSLLILNLSGNSCTNQDGYRELVTEALPL--LLD---LDGQPV-VERWISDEEDEASSDEEFP 197

  Fly   295 --SG----------------SETTAQRPNTA----------------------------PAPEPV 313
              ||                |.....|..||                            .:|...
Human   198 ELSGPFCSERGFLKELEQELSRHREHRQQTALTEHLLRMEMQPTLTDLPLLPGVPMAGDSSPSAT 262

  Fly   314 PIALNAAIRRQVSASSGSTPVAGSVLSLVRQRRRRSGHA---WVSSSSSSGSSSASSARSTRAPS 375
            |......:...||:...|:|.. ...||:.:     ||.   |  ....:.:::|..|....|||
Human   263 PAQGEETVPEAVSSPQASSPTK-KPCSLIPR-----GHQSSFW--GRKGARAATAPKASVAEAPS 319

  Fly   376 MSSCSSNSS 384
            .:..::..|
Human   320 TTKTTAKRS 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14185	NP_649175.1	LRR_8	144..201	CDD:290566	12/56 (21%)
		leucine-rich repeat	146..168	CDD:275380	6/21 (29%)
		LRR_4	168..209	CDD:289563	9/40 (23%)
		leucine-rich repeat	169..190	CDD:275380	1/20 (5%)
		leucine-rich repeat	191..212	CDD:275380	8/20 (40%)
		leucine-rich repeat	213..237	CDD:275380	7/23 (30%)
LRRC46	XP_005257832.1	LRR_8	54..109	CDD:290566	21/92 (23%)
		leucine-rich repeat	55..76	CDD:275378	8/35 (23%)
		LRR_4	75..115	CDD:289563	14/66 (21%)
		leucine-rich repeat	77..98	CDD:275378	7/43 (16%)
		LRR_8	97..151	CDD:290566	20/57 (35%)
		LRR_4	97..135	CDD:289563	13/37 (35%)
		leucine-rich repeat	99..120	CDD:275378	8/20 (40%)
		leucine-rich repeat	121..142	CDD:275378	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0531
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810