DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14185 and NUD1

DIOPT Version :9

Sequence 1:	NP_649175.1	Gene:	CG14185 / 40197	FlyBaseID:	FBgn0036936	Length:	402	Species:	Drosophila melanogaster
Sequence 2:	NP_015018.3	Gene:	NUD1 / 854555	SGDID:	S000005900	Length:	851	Species:	Saccharomyces cerevisiae

Alignment Length:	261	Identity:	56/261 - (21%)
Similarity:	95/261 - (36%)	Gaps:	88/261 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 DLEAVEQVRLRVISYTV---SLSRLSLFLPRLQSLDLSGSVLSSLRDLGY--------------- 164
            |||.::      :||.:   ||..||| ...||.::||.:.:.||..:|.
Yeast   544 DLECLD------LSYNLLNTSLKFLSL-CHHLQEVNLSYNSIQSLEGIGSSRMKKLNLSNNEING 601

  Fly   165 ----------------GLLQLTRLDISNCGLNSFDGTSGLPAIRVLIADGNMIQRVDPLAELVH- 212
                            |.|.:..||:||..:......:.||.::||..:||      ||..:|.
Yeast   602 IIDFEQLILTNNSVVGGWLTVEVLDLSNNNIIGVRNINCLPRLKVLNLNGN------PLVSIVES 660

  Fly   213 -------LRVL----------KARNNRISE--------LGLLSFLGMC---------PQLQEVEL 243
                   ||.|          |.:|.::.:        |.:|...|..         ..||.:|:
Yeast   661 SKMENGTLRALSIKNTGGALSKLQNYKLDDQFTFPYQNLKILKLDGFAQLSKWQKWPATLQILEI 725

  Fly   244 QGNPVCRLPLYRSLLARSVPTLQLLDGRVLNGEPAPVE-----MEEATSPASSDLESGSETTAQR 303
            .|.....||.:.||.:.::.:|.:.:.|.....|..:.     ::|...| .::|::..:.|...
Yeast   726 NGGLASSLPRFSSLKSTNLYSLTIANVRDFTHLPVDLSKELPFLQELHLP-GNNLQNAHKLTKTL 789

  Fly   304 P 304
            |
Yeast   790 P 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14185	NP_649175.1	LRR_8	144..201	CDD:290566	19/87 (22%)
		leucine-rich repeat	146..168	CDD:275380	8/52 (15%)
		LRR_4	168..209	CDD:289563	12/40 (30%)
		leucine-rich repeat	169..190	CDD:275380	5/20 (25%)
		leucine-rich repeat	191..212	CDD:275380	6/20 (30%)
		leucine-rich repeat	213..237	CDD:275380	8/50 (16%)
NUD1	NP_015018.3	LRR	<440..662	CDD:227223	32/130 (25%)
		leucine-rich repeat	522..544	CDD:275380	56/261 (21%)
		leucine-rich repeat	545..567	CDD:275380	9/28 (32%)
		PPP1R42	557..784	CDD:411060	49/234 (21%)
		leucine-rich repeat	568..588	CDD:275380	7/19 (37%)
		leucine-rich repeat	589..621	CDD:275380	1/31 (3%)
		leucine-rich repeat	622..643	CDD:275380	5/20 (25%)
		leucine-rich repeat	699..738	CDD:275380	9/38 (24%)
		leucine-rich repeat	739..768	CDD:275380	4/28 (14%)
		leucine-rich repeat	794..806	CDD:275378
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0531
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900