DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14185 and SDS22

DIOPT Version :9

Sequence 1:	NP_649175.1	Gene:	CG14185 / 40197	FlyBaseID:	FBgn0036936	Length:	402	Species:	Drosophila melanogaster
Sequence 2:	NP_012728.1	Gene:	SDS22 / 853641	SGDID:	S000001676	Length:	338	Species:	Saccharomyces cerevisiae

Alignment Length:	216	Identity:	49/216 - (22%)
Similarity:	82/216 - (37%)	Gaps:	55/216 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 LRRVTQRTDLEAVEQVRLRVISYTVSLSRLSLFLPRLQSLDLSGSV-----------LSSLRDLG 163
            ::.:...||||.:..|: ..||...:||.|.    .|::|:|.|:.           ||:|.::.
Yeast   128 IKNLENLTDLENLYFVQ-NSISKIENLSTLK----SLKNLELGGNKVHSIEPDSFEGLSNLEEIW 187

  Fly   164 YG------------LLQLTRLDISNCGLNSFDGTSGLPAIRVLIADGNMIQRVDPLAELVHLRVL 216
            .|            |..|..|.|.:..|...:....|..:..|....|.|.:::.|.:.:.|..|
Yeast   188 LGKNSIPRLINLHPLKNLKILSIQSNKLKKIENLEELTNLEELYLSHNFITKIEGLEKNLKLTTL 252

  Fly   217 KARNNRISELGLL------------------SF------LGMCPQLQEVELQGNPV---CRLPLY 254
            ...:|:|:.|..|                  ||      |....:|:.:.|:|||:   .:....
Yeast   253 DVTSNKITSLENLNHLSNLTDIWASFNKIDQSFESLGENLSALSRLETIYLEGNPIQLENKTSYR 317

  Fly   255 RSLLARSVPTLQLLDGRVLNG 275
            |.|.....|:||.:|...:.|
Yeast   318 RKLTMNLPPSLQKIDATYIRG 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14185	NP_649175.1	LRR_8	144..201	CDD:290566	16/79 (20%)
		leucine-rich repeat	146..168	CDD:275380	9/44 (20%)
		LRR_4	168..209	CDD:289563	9/40 (23%)
		leucine-rich repeat	169..190	CDD:275380	5/20 (25%)
		leucine-rich repeat	191..212	CDD:275380	4/20 (20%)
		leucine-rich repeat	213..237	CDD:275380	9/47 (19%)
SDS22	NP_012728.1	inl_like_NEAT_1	<42..>174	CDD:411101	14/50 (28%)
		leucine-rich repeat	44..67	CDD:275380
		leucine-rich repeat	68..91	CDD:275380
		leucine-rich repeat	92..114	CDD:275380
		PPP1R42	112..332	CDD:411060	47/208 (23%)
		leucine-rich repeat	115..136	CDD:275380	0/7 (0%)
		leucine-rich repeat	137..158	CDD:275380	8/25 (32%)
		leucine-rich repeat	159..182	CDD:275380	5/22 (23%)
		leucine-rich repeat	183..204	CDD:275380	3/20 (15%)
		leucine-rich repeat	205..248	CDD:275380	9/42 (21%)
		leucine-rich repeat	249..270	CDD:275380	6/20 (30%)
		leucine-rich repeat	271..294	CDD:275380	3/22 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0531
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900