DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14185 and LRRIQ1

DIOPT Version :9

Sequence 1:	NP_649175.1	Gene:	CG14185 / 40197	FlyBaseID:	FBgn0036936	Length:	402	Species:	Drosophila melanogaster
Sequence 2:	XP_011537119.1	Gene:	LRRIQ1 / 84125	HGNCID:	25708	Length:	1760	Species:	Homo sapiens

Alignment Length:	161	Identity:	45/161 - (27%)
Similarity:	75/161 - (46%)	Gaps:	22/161 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 TDLEAVEQVRLRVISYTVSLSRLSLFLPRLQSLDLSGSVLSSLRDLGYGLLQLTRLDISNCGLNS 181
            ||:|.||...|                  ||.|.|.|:.||.|..| ..|:.|..|.:.:..:::
Human  1004 TDVEGVENCGL------------------LQILKLQGNYLSELPSL-ENLVLLRELHLDDNSIST 1049

  Fly   182 FDGTSG--LPAIRVLIADGNMIQRVDPLAELVHLRVLKARNNRISEL-GLLSFLGMCPQLQEVEL 243
            .:..|.  ||.::.:....|.:.::.||...|.|..|...:|.:|:| ..:.:...|..|.|:.|
Human  1050 VEAFSSYWLPLLQNITISQNSLTKIVPLFHFVSLEKLDVSHNCLSDLKSAIKWFDACYSLHELSL 1114

  Fly   244 QGNPVCRLPLYRSLLARSVPTLQLLDGRVLN 274
            .|||:.:...:|..|.:.:|.|::|:|.:||
Human  1115 TGNPLLQETNWRDSLLKVLPALRILNGNILN 1145

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14185	NP_649175.1	LRR_8	144..201	CDD:290566	16/58 (28%)
		leucine-rich repeat	146..168	CDD:275380	10/21 (48%)
		LRR_4	168..209	CDD:289563	8/42 (19%)
		leucine-rich repeat	169..190	CDD:275380	4/22 (18%)
		leucine-rich repeat	191..212	CDD:275380	3/20 (15%)
		leucine-rich repeat	213..237	CDD:275380	6/24 (25%)
LRRIQ1	XP_011537119.1	DUF4515	164..343	CDD:291649
		LRR_4	818..856	CDD:289563
		leucine-rich repeat	820..841	CDD:275380
		leucine-rich repeat	842..862	CDD:275380
		leucine-rich repeat	863..884	CDD:275380
		leucine-rich repeat	885..920	CDD:275380
		leucine-rich repeat	921..970	CDD:275380
		LRR_RI	<963..1095	CDD:238064	28/109 (26%)
		leucine-rich repeat	971..992	CDD:275380
		leucine-rich repeat	993..1014	CDD:275380	5/9 (56%)
		leucine-rich repeat	1015..1036	CDD:275380	10/21 (48%)
		LRR_8	1037..1091	CDD:290566	11/53 (21%)
		leucine-rich repeat	1037..1060	CDD:275380	4/22 (18%)
		leucine-rich repeat	1083..1108	CDD:275380	6/24 (25%)
		leucine-rich repeat	1109..1135	CDD:275380	8/25 (32%)
		IQ	1338..1354	CDD:197470
		IQ	1394..1415	CDD:197470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0531
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900