DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14185 and Lrrc9

DIOPT Version :9

Sequence 1:	NP_649175.1	Gene:	CG14185 / 40197	FlyBaseID:	FBgn0036936	Length:	402	Species:	Drosophila melanogaster
Sequence 2:	XP_006516438.1	Gene:	Lrrc9 / 78257	MGIID:	1925507	Length:	1457	Species:	Mus musculus

Alignment Length:	298	Identity:	69/298 - (23%)
Similarity:	123/298 - (41%)	Gaps:	69/298 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 MP--PPEVRLNQQNPAQQ--------QQQRMQFNRRQLGRRNSFDRDVAIAEEEQHLPAFVHLLP 94
            ||  .|:..|:.:....|        ||...:.||..:|..|                     ||
Mouse  1146 MPRLKPQTHLSSRQLLYQKVPSSGYGQQGTSKLNRDSVGSEN---------------------LP 1189

  Fly    95 VVLPQQGPEPTLDELLRRVTQRTDLEAVEQVRLRVISYTVSLSRLSLFLPRLQSLD---LSGSVL 156
            .:                      ::::|.:.|   .|....:.:.|.|.||::|.   |.|:.:
Mouse  1190 PI----------------------MQSLEVLHL---GYNGICNLVQLQLNRLRNLKFLFLQGNEI 1229

  Fly   157 SSLRDLGYGLLQLTRLDISNCGLNSFDGT--SGLPAIRVLIADGNMIQRVDPLAELVHLRVLKAR 219
            |.:..|. .|:.|..|.:.:..:.:|:.|  |...::.:|..:.|.::.:..|..||.|..|...
Mouse  1230 SQVEGLD-NLIVLQELVVDHNRIRAFNDTAFSKPSSLLMLHLEENRLRELSKLQSLVKLEKLFLG 1293

  Fly   220 NNRISELGLLSFLGMCPQLQEVELQGNPVCRLPLYRSLLARSVPTLQLLDGRVLNGE---PAPVE 281
            .|:|.::..|..|.:.|.|:|:.:.|||:||..::|.:|...:|.||:|||..:|.:   .|...
Mouse  1294 YNKIQDITELEKLDVIPSLRELTVYGNPICRKMVHRHVLIFRLPNLQMLDGIPINSDDRAKAEFH 1358

  Fly   282 MEEATSPASSDLESGSETT-AQRPNTAPAPEP---VPI 315
            ..|..:..||.:::...|: :..|:....|.|   ||:
Mouse  1359 FSELQAKKSSIIQNNLPTSKSSLPSHLQTPLPCKFVPV 1396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14185	NP_649175.1	LRR_8	144..201	CDD:290566	15/61 (25%)
		leucine-rich repeat	146..168	CDD:275380	7/24 (29%)
		LRR_4	168..209	CDD:289563	8/42 (19%)
		leucine-rich repeat	169..190	CDD:275380	5/22 (23%)
		leucine-rich repeat	191..212	CDD:275380	4/20 (20%)
		leucine-rich repeat	213..237	CDD:275380	6/23 (26%)
Lrrc9	XP_006516438.1	internalin_A	<32..>264	CDD:380193
		leucine-rich repeat	47..77	CDD:275380
		leucine-rich repeat	78..99	CDD:275380
		leucine-rich repeat	100..121	CDD:275380
		leucine-rich repeat	122..143	CDD:275380
		leucine-rich repeat	144..166	CDD:275380
		leucine-rich repeat	167..191	CDD:275380
		leucine-rich repeat	192..223	CDD:275380
		internalin_A	685..>959	CDD:380193
		leucine-rich repeat	689..708	CDD:275380
		leucine-rich repeat	709..730	CDD:275380
		leucine-rich repeat	731..752	CDD:275380
		leucine-rich repeat	753..779	CDD:275380
		leucine-rich repeat	780..806	CDD:275380
		leucine-rich repeat	807..865	CDD:275380
		leucine-rich repeat	866..901	CDD:275380
		internalin_A	879..>1262	CDD:380193	31/162 (19%)
		leucine-rich repeat	902..923	CDD:275380
		leucine-rich repeat	924..945	CDD:275380
		leucine-rich repeat	946..969	CDD:275380
		leucine-rich repeat	992..1016	CDD:275380
		leucine-rich repeat	1017..1044	CDD:275380
		leucine-rich repeat	1132..1157	CDD:275380	4/10 (40%)
		leucine-rich repeat	1158..1194	CDD:275380	9/78 (12%)
		leucine-rich repeat	1195..1218	CDD:275380	7/25 (28%)
		leucine-rich repeat	1219..1240	CDD:275380	6/21 (29%)
		LRR_9	<1227..1366	CDD:373143	38/139 (27%)
		leucine-rich repeat	1241..1264	CDD:275380	5/22 (23%)
		leucine-rich repeat	1265..1286	CDD:275380	4/20 (20%)
		leucine-rich repeat	1287..1311	CDD:275380	6/23 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0531
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810