Protein Alignment CG14185 and Lrrc46

DIOPT Version :10

• Sequence 1: NP_649175.1
• Gene: CG14185 / 40197
• FlyBaseID: FBgn0036936
• Length: 402
• Species: Drosophila melanogaster
• Sequence 2: NP_081302.2
• Gene: Lrrc46 / 69297
• MGIID: 1916547
• Length: 323
• Species: Mus musculus
• Alignment Length: 359
• Identity: 74/359 - (20%)
• Similarity: 122/359 - (33%)
• Gaps: 117/359 - (32%)

  Fly   104 PTLDELLRRVTQRTDLEAVEQVRLRVISYTVSLSRLSLFLPRLQSLDLSGSVLSSLRDLGYGLLQ 168
            |..::..::..|||:    |.|.:.    ...:::.:|..|..:  |||..:..:|     |.|:
Mouse     2 PGDEQEAKKAAQRTE----EGVHIT----EALITKRNLTFPGDE--DLSEKMFHTL-----GELE 51

  Fly   169 LTRLDISNCGLNSFDGTSGLPAIRVLIADGNMIQRVDPLAELVHLRVLKARNNRIS------ELG 227
            ..|||  ..|:........|..|..|....|.|||::.||.:..||.|....|:|.      :|.
Mouse    52 TVRLD--GEGITCIGNLEKLRNIHSLYLQSNKIQRIENLACITSLRFLSLARNQIRHVENLLDLQ 114

  Fly   228 LLSFLGMCPQLQE-------------VELQGNPVCRLPLYRSLLARSVPTLQLLDGR-------- 271
            .|.||.:...|.|             :.|.|||......||.::..::|.|..||.:
Mouse   115 YLQFLDLSENLIETLKLDELPESLLILNLCGNPCTNQEGYRKMVIGALPLLLDLDKQPILERWTS 179

  Fly   272 --------------VLNG-----------------------------------EPAPVEMEEATS 287
                          .|||                                   |..||..:....
Mouse   180 DEEDKSSDDDDEFPELNGPFCAERGFFKDLEQELHQHQERRQQAALTEHLSRMETQPVLTDLPLL 244

  Fly   288 PASSDLESGSETTAQRPNTAPAPEPVPIALNAAIRRQVSASSGSTPVAGSVLSLVRQRRRRSGHA 352
            ||.......|.|...:|....||:                ::.||..|.:....|.:.::.|..|
Mouse   245 PAVPMAGDCSSTATDQPGKESAPK----------------ATSSTQTASTTKKQVSKNQKSSVQA 293

  Fly   353 WVSSSSSSGSSSASSARSTRA--PSMSSCSSNSS 384
                  ..|:.:|:::::::|  |||:..::..|
Mouse   294 ------RKGALAATTSKTSQAATPSMTKMTNKKS 321

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14185	NP_649175.1	leucine-rich repeat	146..168	CDD:275380	5/21 (24%)
		PPP1R42	<169..271	CDD:455733	34/120 (28%)
		leucine-rich repeat	169..190	CDD:275380	5/20 (25%)
		leucine-rich repeat	191..212	CDD:275380	8/20 (40%)
		leucine-rich repeat	213..237	CDD:275380	9/29 (31%)
Lrrc46	NP_081302.2	LRR 1	49..70		5/22 (23%)
		leucine-rich repeat	50..71	CDD:275378	6/22 (27%)
		PPP1R42	60..>146	CDD:455733	21/85 (25%)
		LRR 2	71..92		8/20 (40%)
		leucine-rich repeat	72..93	CDD:275378	8/20 (40%)
		LRR 3	93..114		5/20 (25%)
		leucine-rich repeat	94..115	CDD:275378	6/20 (30%)
		LRR 4	115..135		5/19 (26%)
		leucine-rich repeat	116..137	CDD:275378	5/20 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	249..323		18/95 (19%)