DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14185 and Lrrc6

DIOPT Version :9

Sequence 1:	NP_649175.1	Gene:	CG14185 / 40197	FlyBaseID:	FBgn0036936	Length:	402	Species:	Drosophila melanogaster
Sequence 2:	NP_062330.1	Gene:	Lrrc6 / 54562	MGIID:	1859553	Length:	473	Species:	Mus musculus

Alignment Length:	184	Identity:	48/184 - (26%)
Similarity:	72/184 - (39%)	Gaps:	28/184 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 DELLRRVTQRTDLEAVEQVRLRVISYTVSLSRLSLF---LPRLQSLDLSGSVLSSLRDLGYGLLQ 168
            ::|:||..:..|.         ||   .||..|||.   :.||:.:|      ...|||....||
Mouse     6 EDLIRRNAEHNDC---------VI---FSLEELSLHQQEIERLEHID------KWCRDLKILYLQ 52

  Fly   169 LTRLDISNCGLNSFDGTSGLPAIRVLIADGNMIQRVDPLAELVHLRVLKARNNRISELGLLSFLG 233
                   |..:...:..|.|..:..|....|.|:|::.|.....|..|....|.|.||..:..|.
Mouse    53 -------NNLIGKIENVSKLKKLEYLNLALNNIERIENLEGCEWLTKLDLTVNFIGELSSVKTLT 110

  Fly   234 MCPQLQEVELQGNPVCRLPLYRSLLARSVPTLQLLDGRVLNGEPAPVEMEEATS 287
            ....|:|:.|.|||......||..:..::..|:.|||:.:........::..||
Mouse   111 HNIHLKELFLMGNPCADFDGYRQFVVVTLQQLKWLDGKEIERSERIQALQNYTS 164

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14185	NP_649175.1	LRR_8	144..201	CDD:290566	13/56 (23%)
		leucine-rich repeat	146..168	CDD:275380	5/21 (24%)
		LRR_4	168..209	CDD:289563	9/40 (23%)
		leucine-rich repeat	169..190	CDD:275380	3/20 (15%)
		leucine-rich repeat	191..212	CDD:275380	5/20 (25%)
		leucine-rich repeat	213..237	CDD:275380	7/23 (30%)
Lrrc6	NP_062330.1	LRR_4	22..64	CDD:289563	14/54 (26%)
		LRR 1	22..43		8/26 (31%)
		leucine-rich repeat	23..45	CDD:275378	7/27 (26%)
		LRR 2	45..66		6/27 (22%)
		LRR_8	46..98	CDD:290566	13/58 (22%)
		LRR_4	46..86	CDD:289563	11/46 (24%)
		leucine-rich repeat	46..67	CDD:275378	6/27 (22%)
		LRR 3	67..88		5/20 (25%)
		leucine-rich repeat	68..89	CDD:275378	5/20 (25%)
		LRR 4	89..110		6/20 (30%)
		leucine-rich repeat	90..114	CDD:275378	7/23 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	188..244
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	273..292
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..473
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0531
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810