DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG14185 and Lrrc43

DIOPT Version :9

Sequence 1:NP_649175.1 Gene:CG14185 / 40197 FlyBaseID:FBgn0036936 Length:402 Species:Drosophila melanogaster
Sequence 2:NP_001028633.1 Gene:Lrrc43 / 381741 MGIID:2685907 Length:667 Species:Mus musculus


Alignment Length:444 Identity:97/444 - (21%)
Similarity:154/444 - (34%) Gaps:146/444 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    75 RDVAIAEEEQHLP---AFVHLLPVVLPQQGPEPTL------DELLRRVTQRTDLEAVEQV----- 125
            |::...|||..:|   ....||.:|.....|...|      |..||.:..:..|...:..     
Mouse    62 RELVPKEEETLVPEEETVEALLGLVRSNHSPWAMLKDASAEDRFLRELAIQNPLMIKDTFFYSYF 126

  Fly   126 -RLRVISYTVSL--SRLSLFL---------------------PRLQSLDLSGSVLSS-------- 158
             .|||::..|||  ..|..||                     |.|:.|:|.|::::|        
Mouse   127 RSLRVVNKGVSLVDKDLLKFLKLEELVLSANKIEEIDANNLPPTLKVLELYGNLIASMECLCSAP 191

  Fly   159 ---LRDLGYG---LL--------------QLTRLDISNCGLNSFD-------GTSGLPAIRVLIA 196
               |:.||.|   ||              ||..||:   |.|:..       |.|.|..:|:|:.
Mouse   192 PPRLQHLGLGHNKLLGPLESLYVTSHNWPQLVSLDL---GFNNLTDLQNMILGLSTLRHLRLLVL 253

  Fly   197 DGNMIQRVDPLAELVHLRVLKARNNRISELGLLSFLGMCPQLQEVELQGNPVCRLPLYRSLLARS 261
            .||      ||:.:.:.|....  :.::.|.:|..:.:.|. ::.:.:|     |.::..||||.
Mouse   254 QGN------PLSLVPYYRGFTI--DSLAHLCVLDDITVSPN-EKHQFRG-----LNIHGDLLARE 304

  Fly   262 ---VPTL----QLLDGRVLNGEPAP---------------VEMEEATSPASSDLE---------- 294
               |.|:    .:||..:|:.||.|               ||.|:.....|..:|          
Mouse   305 AQFVVTIGNVRGVLDSSILDPEPGPDGPFISYSYYVTYDFVEDEDMERNVSGLVEATHHDSVLDE 369

  Fly   295 -----SGSETTAQRPNTAPAPEPVPIALNAAIRRQVSASSGSTPVAGSVLS-LVRQRRRRSGHAW 353
                 ||::...|:.:        |:......|.:.....|||......|| .:.:...:.....
Mouse   370 IDKHFSGTDEEDQQED--------PLDGRHRHRGRQRFHPGSTEEMSKELSEFIAKEMSQMAEGS 426

  Fly   354 VSSSSSSGSSSASSARSTRAPSMSSCSSNSSL-------DVQ---SSSHYVFST 397
            |.|..:....|.:|.....||...|..|:..|       |:|   |....:|:|
Mouse   427 VESGITEVDWSETSISIHSAPLPQSIDSSEELAKLRPKIDIQLCPSPGTVLFNT 480

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG14185NP_649175.1 LRR_8 144..201 CDD:290566 25/91 (27%)
leucine-rich repeat 146..168 CDD:275380 11/49 (22%)
LRR_4 168..209 CDD:289563 15/47 (32%)
leucine-rich repeat 169..190 CDD:275380 8/27 (30%)
leucine-rich repeat 191..212 CDD:275380 6/20 (30%)
leucine-rich repeat 213..237 CDD:275380 3/23 (13%)
Lrrc43NP_001028633.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..24
LRR 1 148..169 0/20 (0%)
LRR <154..>263 CDD:227223 27/117 (23%)
LRR 2 170..191 5/20 (25%)
leucine-rich repeat 171..194 CDD:275378 5/22 (23%)
LRR 3 194..213 6/18 (33%)
leucine-rich repeat 195..221 CDD:275378 6/25 (24%)
LRR 4 221..242 6/23 (26%)
leucine-rich repeat 222..247 CDD:275378 8/27 (30%)
leucine-rich repeat 248..259 CDD:275378 5/16 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 374..407 8/40 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 533..570
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 616..640
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0531
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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