DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14185 and Lrrc23

DIOPT Version :9

Sequence 1:	NP_649175.1	Gene:	CG14185 / 40197	FlyBaseID:	FBgn0036936	Length:	402	Species:	Drosophila melanogaster
Sequence 2:	NP_001381276.1	Gene:	Lrrc23 / 312707	RGDID:	1304779	Length:	345	Species:	Rattus norvegicus

Alignment Length:	249	Identity:	63/249 - (25%)
Similarity:	102/249 - (40%)	Gaps:	47/249 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 DRDVAIAEEEQHLPAFVHLLPVVLPQ-----QGPEPTLDELLRRVTQRTDLEAVEQVRLRVISY- 132
            |||:.   :...|.:::||..|.:.:     ..|   |:.|...:..:.|...:...||..:.|
  Rat    80 DRDLT---DISLLRSYIHLRYVDISENHITDMSP---LNSLTHLLWLKADGNQLRSARLNELPYL 138

  Fly   133 ---TVSLSRLS----LFLPRLQSLDLSGSVLSSLRDLGYGLLQLTRLDISNCGLNSFDGTSG--L 188
               :.|.::::    :..|||.||||.|:.:..:  .|....:||.|.......|..:.|.|  |
  Rat   139 QIASFSYNQITDTEGIIHPRLGSLDLKGNRIHQV--TGLDPERLTNLHTLELRANQLETTIGINL 201

  Fly   189 PAIRVLIADGNMIQRVDPLAEL-----VHLR------------------VLKARNNRISELGLLS 230
            |.::.|....|::::|:.|..|     :|||                  .|..|:|.||:||.|:
  Rat   202 PKLKNLYLAQNLLKKVEGLENLSNLTTLHLRDNQIETLDGFSKEMKSLQYLNLRSNMISDLGELA 266

  Fly   231 FLGMCPQLQEVELQGNPVCRLPLYRSLLARSVPTLQLLDGRVLNGEPAPVEMEE 284
            .|...|:|:.:.|..||......||......:..|:.||......|.. .|.||
  Rat   267 KLRDLPKLRALVLLDNPCADETDYRQEALVQMAHLERLDKEYYEDEDR-AEAEE 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14185	NP_649175.1	LRR_8	144..201	CDD:290566	19/58 (33%)
		leucine-rich repeat	146..168	CDD:275380	7/21 (33%)
		LRR_4	168..209	CDD:289563	12/42 (29%)
		leucine-rich repeat	169..190	CDD:275380	7/22 (32%)
		leucine-rich repeat	191..212	CDD:275380	5/25 (20%)
		leucine-rich repeat	213..237	CDD:275380	11/41 (27%)
Lrrc23	NP_001381276.1	leucine-rich repeat	75..94	CDD:275380	4/16 (25%)
		PPP1R42	80..306	CDD:411060	58/233 (25%)
		leucine-rich repeat	95..116	CDD:275380	5/23 (22%)
		leucine-rich repeat	117..137	CDD:275380	3/19 (16%)
		leucine-rich repeat	138..158	CDD:275380	1/19 (5%)
		leucine-rich repeat	159..182	CDD:275380	8/24 (33%)
		leucine-rich repeat	183..203	CDD:275380	5/19 (26%)
		leucine-rich repeat	204..225	CDD:275380	5/20 (25%)
		leucine-rich repeat	226..248	CDD:275380	3/21 (14%)
		leucine-rich repeat	249..273	CDD:275380	9/23 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0531
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810