Protein Alignment CG14185 and Cntrl

DIOPT Version :10

• Sequence 1: NP_649175.1
• Gene: CG14185 / 40197
• FlyBaseID: FBgn0036936
• Length: 402
• Species: Drosophila melanogaster
• Sequence 2: NP_001366203.1
• Gene: Cntrl / 26920
• MGIID: 1889576
• Length: 2334
• Species: Mus musculus
• Alignment Length: 319
• Identity: 72/319 - (22%)
• Similarity: 128/319 - (40%)
• Gaps: 71/319 - (22%)

  Fly    20 QAELPILLAPPGPAALAQVRMPPPEVRLNQQNPAQQQQQRMQFNRRQLGRRNSFDRDVAIAEEEQ 84
            :|::|:....|||::|                       |.....|.|        ...|..|.|
Mouse    11 KAKMPLSSHFPGPSSL-----------------------RSSMRSRSL--------SPLIGSETQ 44

  Fly    85 HL------PAFVHL-----LPVVLPQQ--------GPEPTLDELLRRVTQRTDLEAVEQVRL--- 127
            .|      ||...|     :|:. |||        |.....:.|::::|::.:|..|:.:.|
Mouse    45 PLHPGGQWPAQAELTDESTVPLE-PQQRKGAESYVGVRYITEALIKKLTKQDNLALVKSLNLSLS 108

  Fly   128 ----RVISYTVSLSRLSLFLPRLQSLDLSGSVLSSLRDLGYGLLQLTRLDISNCGLNSFDGTSGL 188
                :...|..:|.:    ..:|:.|:||.:::..:..:. .||:|..|::|...::..:|...:
Mouse   109 KDGGKKFRYIENLEK----CVKLEVLNLSYNLIVKIEKVD-KLLRLRELNLSYNKISKIEGLENM 168

  Fly   189 PAIRVLIADGNMIQRVDPL---AELVHLRVLKARNNRISELGLLSFLGMCPQLQEVELQGNPVCR 250
            ..::.|...||.|:.: |:   .:|..||||..:.|:||.|..:|.|.....|..:.|..|||..
Mouse   169 CNLQKLNLAGNEIEHI-PVWFAKKLKSLRVLNLKGNKISSLQDVSKLKPLQDLTSLVLIDNPVVA 232

  Fly   251 LPLYRSLLARSVPTLQLLDGRVLNGEPAPVEME----EATSPASSDLESGSETTAQRPN 305
            ||.|...:...:.:|:.|:|:.:..:......|    |.......|||..:..|.:..|
Mouse   233 LPHYLQFIIFHLRSLESLEGQPVTTQDRQEAFERFSLEEIERLEKDLEKKTVETEELKN 291

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14185	NP_649175.1	leucine-rich repeat	146..168	CDD:275380	5/21 (24%)
		PPP1R42	<169..271	CDD:455733	30/104 (29%)
		leucine-rich repeat	169..190	CDD:275380	4/20 (20%)
		leucine-rich repeat	191..212	CDD:275380	6/23 (26%)
		leucine-rich repeat	213..237	CDD:275380	10/23 (43%)
Cntrl	NP_001366203.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..70		18/90 (20%)
		PPP1R42	89..261	CDD:455733	43/177 (24%)
		leucine-rich repeat	100..119	CDD:275378	3/18 (17%)
		LRR 1	126..147		4/21 (19%)
		leucine-rich repeat	127..148	CDD:275380	5/21 (24%)
		LRR 2	148..169		4/20 (20%)
		leucine-rich repeat	149..170	CDD:275380	4/20 (20%)
		LRR 3	170..191		5/21 (24%)
		leucine-rich repeat	171..194	CDD:275380	6/23 (26%)
		LRR 4	194..215		9/20 (45%)
		leucine-rich repeat	195..219	CDD:275380	10/23 (43%)
		leucine-rich repeat	220..246	CDD:275380	8/25 (32%)
		Smc	441..>1097	CDD:440809
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	542..562
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	751..771
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1154..1198
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1213..1245
		Drf_FH1	<1239..1310	CDD:461881
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1338..1360
		SMC_prok_B	1407..2216	CDD:274008
		Required for centrosome localization. /evidence=ECO:0000250	1951..2121
		Sufficient for interaction with HOOK2. /evidence=ECO:0000250	1988..2334
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2291..2334