DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14185 and R02F11.4

DIOPT Version :9

Sequence 1:	NP_649175.1	Gene:	CG14185 / 40197	FlyBaseID:	FBgn0036936	Length:	402	Species:	Drosophila melanogaster
Sequence 2:	NP_504289.1	Gene:	R02F11.4 / 178871	WormBaseID:	WBGene00019842	Length:	630	Species:	Caenorhabditis elegans

Alignment Length:	312	Identity:	67/312 - (21%)
Similarity:	114/312 - (36%)	Gaps:	69/312 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 LQSLDLSGSVLSSLRDLGYGLLQLTRLDISNCGLNSFDGTSGLPAIRVLIADGNMIQRVDPLAEL 210
            |:.||||.:::..  .:.:.|..|..|::|...||.....|...|::.:....|.|..:..:.:|
Worm   144 LKILDLSNNLIEP--PVSFSLKNLEILNLSGNFLNEIPDLSKCVALQTISLADNKISDLTTITKL 206

  Fly   211 V---HLRVLKARNNRISELGLLSFLGMCPQLQEVELQGNPVCRLPL------YRS-LLARSVPTL 265
            :   :|:.|...:|.|.:|...|.|....:|:|..:.|||.....|      ||| :.|.....|
Worm   207 ICPTNLKNLDISSNSIEDLSQFSVLSTFKKLEEFVVAGNPSITSVLDSDLFDYRSYIFACCSEQL 271

  Fly   266 QLLDGRVL--------------------------------------NGEPAP--------VEMEE 284
            ..:||:.:                                      :|.|.|        :|...
Worm   272 HTIDGQKIEDQVQTEGEWLALQGSIKKIGPGNHDALCQQIASHFPDSGPPTPAQKSCHKALEKRR 336

  Fly   285 ATSPASSDLESGSETTAQRPNTAPAP-EPVPIALNAAIRRQVSASSGSTPVAGSVLSLVRQRRRR 348
            :.......||..||.|.:..|:..:| ......:.|.:..:.|.||...|| ...|.:......|
Worm   337 SMKVPEKHLEEFSEDTDRTENSVYSPFREWNGKIGALMTPEASGSSRRIPV-NKNLRMCSPPEAR 400

  Fly   349 SGHAWVSSSSSSGSSSASSAR---STRAPSMSS--CSSNS----SLDVQSSS 391
            ....:...:.:|.:....:.|   |||:.|..:  |||.:    ::|.:|.|
Worm   401 KNKTFKFQNETSPNRYPENFRPLGSTRSISTETVICSSRTEVSFTVDGRSES 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14185	NP_649175.1	LRR_8	144..201	CDD:290566	14/54 (26%)
		leucine-rich repeat	146..168	CDD:275380	6/21 (29%)
		LRR_4	168..209	CDD:289563	9/40 (23%)
		leucine-rich repeat	169..190	CDD:275380	6/20 (30%)
		leucine-rich repeat	191..212	CDD:275380	3/23 (13%)
		leucine-rich repeat	213..237	CDD:275380	7/23 (30%)
R02F11.4	NP_504289.1	leucine-rich repeat	57..78	CDD:275380
		LRR_RI	<118..245	CDD:238064	25/102 (25%)
		leucine-rich repeat	122..143	CDD:275380
		LRR_8	143..197	CDD:290566	14/54 (26%)
		leucine-rich repeat	144..164	CDD:275380	6/21 (29%)
		LRR_4	163..205	CDD:289563	9/41 (22%)
		leucine-rich repeat	165..186	CDD:275380	6/20 (30%)
		leucine-rich repeat	187..211	CDD:275380	3/23 (13%)
		leucine-rich repeat	212..236	CDD:275380	7/23 (30%)
		leucine-rich repeat	237..256	CDD:275380	6/18 (33%)
		DUF2730	<480..557	CDD:287743
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0531
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810