DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14185 and K10D2.8

DIOPT Version :9

Sequence 1:	NP_649175.1	Gene:	CG14185 / 40197	FlyBaseID:	FBgn0036936	Length:	402	Species:	Drosophila melanogaster
Sequence 2:	NP_001254924.1	Gene:	K10D2.8 / 13189483	WormBaseID:	WBGene00189952	Length:	335	Species:	Caenorhabditis elegans

Alignment Length:	277	Identity:	59/277 - (21%)
Similarity:	110/277 - (39%)	Gaps:	85/277 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 LGRRNSFDRDVAIAEEEQHLPAFVHLLPVVLPQQGPEPTLDELLRRVT------QRTDLEAVEQV 125
            |.|.|..|..:   |:.::|...|:|:           .||....|:|      :..:||.:..|
Worm    73 LTRLNLNDNQI---EKLENLETLVNLV-----------FLDVSYNRITKIEGLSELINLEELHLV 123

  Fly   126 RLRVI---------------------------SYTVSLSRLSL------------FLPRLQSLDL 151
            ..::|                           |:.|:|.||.|            .:.:|:.|.|
Worm   124 HNKIITIEGLETNTAMKYLEFGDNRIQKMENLSHLVNLERLFLGANQIRKIEGLDGMAQLKELSL 188

  Fly   152 SGSVLSSLRDLGYGLLQLTRLDISNCGLNSFDGTSGLPAIRVLIADGNMIQRVDPLAELVHLRVL 216
            .|:.|..:..|. .|..|..:.::..|:...||.|||..::.|..:.|:|::::.:.:...:..|
Worm   189 PGNALQIIEGLD-TLSGLKSISLAQNGIRKIDGLSGLTNLKSLDLNDNIIEKLENVEQFKGISSL 252

  Fly   217 KARNNRISELGLLSFLGMC----PQLQEVE------LQGNPVCRLP-LYRSLLARSVPTLQLLDG 270
            ..|.|:::          |    .||:::|      ::.||:.... .||:.:...:|.::||||
Worm   253 MIRKNKLN----------CWQDVRQLKKLENLTVLTMEMNPLYSSDYTYRNRVKEILPDVKLLDG 307

  Fly   271 RVL---NGEP-APVEME 283
            ..:   .|:| .|:..|
Worm   308 FPIFWVQGDPYQPIPEE 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14185	NP_649175.1	LRR_8	144..201	CDD:290566	16/56 (29%)
		leucine-rich repeat	146..168	CDD:275380	7/21 (33%)
		LRR_4	168..209	CDD:289563	10/40 (25%)
		leucine-rich repeat	169..190	CDD:275380	7/20 (35%)
		leucine-rich repeat	191..212	CDD:275380	3/20 (15%)
		leucine-rich repeat	213..237	CDD:275380	4/27 (15%)
K10D2.8	NP_001254924.1	leucine-rich repeat	30..50	CDD:275380
		LRR_4	49..90	CDD:289563	5/19 (26%)
		leucine-rich repeat	51..72	CDD:275380
		LRR_8	71..127	CDD:290566	15/67 (22%)
		LRR_4	71..113	CDD:289563	12/53 (23%)
		leucine-rich repeat	73..94	CDD:275380	6/23 (26%)
		LRR_4	94..134	CDD:289563	9/50 (18%)
		leucine-rich repeat	95..116	CDD:275380	5/31 (16%)
		LRR_4	116..157	CDD:289563	4/40 (10%)
		leucine-rich repeat	117..138	CDD:275380	4/20 (20%)
		leucine-rich repeat	139..160	CDD:275380	1/20 (5%)
		LRR_4	160..199	CDD:289563	9/38 (24%)
		leucine-rich repeat	161..182	CDD:275380	4/20 (20%)
		LRR_8	182..235	CDD:290566	15/53 (28%)
		leucine-rich repeat	183..204	CDD:275380	7/21 (33%)
		LRR_4	205..245	CDD:289563	10/39 (26%)
		leucine-rich repeat	205..226	CDD:275380	7/20 (35%)
		leucine-rich repeat	252..273	CDD:275380	6/30 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0531
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810